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Akademický článek

Thyroid hormones regulate cardiac repolarization and QT-interval related gene expression in hiPSC cardiomyocytes

Autor: Alessandra Ulivieri, Luca Lavra, Fiorenza Magi, Alessandra Morgante, Leonardo Calò, Patrizio Polisca, Leila B. Salehi, Salvatore Sciacchitano

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)

Abstract Prolongation of cardiac repolarization (QT interval) represents a dangerous and potentially life-threatening electrical event affecting the heart. Thyroid hormones (THs) are critical for cardiac development and heart function. However, littl

Externí odkaz: https://doaj.org/article/45d4986c2186402cab95fe2b57f81153

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Akademický článek

Nonthyroidal illness syndrome (NTIS) in severe COVID-19 patients: role of T3 on the Na/K pump gene expression and on hydroelectrolytic equilibrium

Publikováno v: Journal of Translational Medicine, Vol 19, Iss 1, Pp 1-18 (2021)

Abstract Background Nonthyroidal Illness Syndrome (NTIS) can be detected in many critical illnesses. Recently, we demonstrated that this condition is frequently observed in COVID-19 patients too and it is correlated with the severity the disease. How

Externí odkaz: https://doaj.org/article/6a0564040064407393f87c777bb37eb4

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Akademický článek

Generation and characterization of the human induced pluripotent stem cell (hiPSC) line NCUFi001-A from a patient carrying KCNQ1 G314S mutation

Autor: Luca Lavra, Fiorenza Magi, Alessandra Ulivieri, Alessandra Morgante, Marianna Paulis, Luca Sala, Matteo Pedrazzini, Patrizio Polisca, Marcella Rocchetti, Leonardo Calò, Salvatore Sciacchitano, Leila B. Salehi

Publikováno v: Stem Cell Research, Vol 54, Iss , Pp 102418- (2021)

In this study we describe the generation and characterization of an human induced pluripotent stem cell (hiPSC) line from a long QT syndrome type 1 (LQT1) patient carrying the KCNQ1 c.940 G > A (p.Gly314Ser) mutation. This patient-specific iPSC line

Externí odkaz: https://doaj.org/article/3dee8cd02ef6407b96a8a6deaf2c1067

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Akademický článek

The loss of the p53 activator HIPK2 is responsible for galectin-3 overexpression in well differentiated thyroid carcinomas.

Autor: Luca Lavra, Cinzia Rinaldo, Alessandra Ulivieri, Emidio Luciani, Paolo Fidanza, Laura Giacomelli, Carlo Bellotti, Alberto Ricci, Maria Trovato, Silvia Soddu, Armando Bartolazzi, Salvatore Sciacchitano

Publikováno v: PLoS ONE, Vol 6, Iss 6, p e20665 (2011)

BACKGROUND: Galectin-3 (Gal-3) is an anti-apoptotic molecule involved in thyroid cells transformation. It is specifically overexpressed in thyroid tumour cells and is currently used as a preoperative diagnostic marker of thyroid malignancy. Gal-3 exp

Externí odkaz: https://doaj.org/article/cf3bb61a44fd4cf0a634b485b4d3ca5d

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Akademický článek

Thyroid cancer imaging in vivo by targeting the anti-apoptotic molecule galectin-3.

Autor: Armando Bartolazzi, Calogero D'Alessandria, Maria Gemma Parisella, Alberto Signore, Fabrizio Del Prete, Luca Lavra, Sten Braesch-Andersen, Roberto Massari, Carlo Trotta, Alessandro Soluri, Salvatore Sciacchitano, Francesco Scopinaro

Publikováno v: PLoS ONE, Vol 3, Iss 11, p e3768 (2008)

BackgroundThe prevalence of thyroid nodules increases with age, average 4-7% for the U.S.A. adult population, but it is much higher (19-67%) when sub-clinical nodules are considered. About 90% of these lesions are benign and a reliable approach to th

Externí odkaz: https://doaj.org/article/4829821531024d6984357829312b9852

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Generation and characterization of the human induced pluripotent stem cell (hiPSC) line NCUFi001-A from a patient carrying KCNQ1 G314S mutation

Autor: Matteo Pedrazzini, Alessandra Morgante, Marianna Paulis, Salvatore Sciacchitano, Fiorenza Magi, Leonardo Calò, Alessandra Ulivieri, Marcella Rocchetti, Luca Lavra, Leila B. Salehi, Luca Sala, Patrizio Polisca

Publikováno v: Stem Cell Research, Vol 54, Iss, Pp 102418-(2021)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd04edd4aa821b1df06bf4d020d8ac89
http://hdl.handle.net/10281/339398

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Nonthyroidal illness syndrome (NTIS) in severe COVID-19 patients: role of T3 on the Na/K pump gene expression and on hydroelectrolytic equilibrium

Publikováno v: Journal of Translational Medicine, Vol 19, Iss 1, Pp 1-18 (2021)
Journal of Translational Medicine

Background Nonthyroidal Illness Syndrome (NTIS) can be detected in many critical illnesses. Recently, we demonstrated that this condition is frequently observed in COVID-19 patients too and it is correlated with the severity the disease. However, the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb9afd7b9bbefed706d0d4f10793d081
http://hdl.handle.net/11573/1591395

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Galectin-3: One Molecule for an Alphabet of Diseases, from A to Z

Autor: Leila B. Salehi, Carlo Bellotti, Alberto Ricci, Alessandra Morgante, Salvatore Sciacchitano, Luca Lavra, Fiorenza Magi, Alessandra Ulivieri, Gian Paolo De Francesco

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 19, Iss 2, p 379 (2018)

Galectin-3 (Gal-3) regulates basic cellular functions such as cell–cell and cell–matrix interactions, growth, proliferation, differentiation, and inflammation. It is not surprising, therefore, that this protein is involved in the pathogenesis of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fdd8c9c6162a67fafc7a04da5b120cc
https://pubmed.ncbi.nlm.nih.gov/29373564

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