Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Luca Goitre"'
Autor:
Luca Goitre, Peter V. DiStefano, Andrea Moglia, Nicholas Nobiletti, Eva Baldini, Lorenza Trabalzini, Julie Keubel, Eliana Trapani, Vladimir V. Shuvaev, Vladimir R. Muzykantov, Ingrid H. Sarelius, Saverio Francesco Retta, Angela J. Glading
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract The intracellular scaffold KRIT1/CCM1 is an established regulator of vascular barrier function. Loss of KRIT1 leads to decreased microvessel barrier function and to the development of the vascular disorder Cerebral Cavernous Malformation (CC
Externí odkaz:
https://doaj.org/article/6fc3adc7ae70457492848b492ff196e1
Autor:
Saverio Marchi, Mariangela Corricelli, Eliana Trapani, Luca Bravi, Alessandra Pittaro, Simona Delle Monache, Letizia Ferroni, Simone Patergnani, Sonia Missiroli, Luca Goitre, Lorenza Trabalzini, Alessandro Rimessi, Carlotta Giorgi, Barbara Zavan, Paola Cassoni, Elisabetta Dejana, Saverio Francesco Retta, Paolo Pinton
Publikováno v:
EMBO Molecular Medicine, Vol 7, Iss 11, Pp 1403-1417 (2015)
Abstract Cerebral cavernous malformation (CCM) is a major cerebrovascular disease affecting approximately 0.3–0.5% of the population and is characterized by enlarged and leaky capillaries that predispose to seizures, focal neurological deficits, an
Externí odkaz:
https://doaj.org/article/5b50193f8a5849aebd091244eb7e131d
Autor:
Paolo Guazzi, Luca Goitre, Elisa Ferro, Valentina Cutano, Chiara Martino, Lorenza Trabalzini, Saverio Francesco Retta
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e44705 (2012)
Loss-of-function mutations of the KRIT1 gene (CCM1) have been associated with the Cerebral Cavernous Malformation (CCM) disease, which is characterized by serious alterations of brain capillary architecture. The KRIT1 protein contains multiple intera
Externí odkaz:
https://doaj.org/article/83a17b70980a4e65bc8ee65bdc4cbc4c
Autor:
Luca Goitre, Fiorella Balzac, Simona Degani, Paolo Degan, Saverio Marchi, Paolo Pinton, Saverio Francesco Retta
Publikováno v:
PLoS ONE, Vol 5, Iss 7, p e11786 (2010)
KRIT1 is a gene responsible for Cerebral Cavernous Malformations (CCM), a major cerebrovascular disease characterized by abnormally enlarged and leaky capillaries that predispose to seizures, focal neurological deficits, and fatal intracerebral hemor
Externí odkaz:
https://doaj.org/article/e9ba7c9c5a99403097ad4f4e4a709e76
Autor:
Raffaella Mastrocola, Eleonora Aimaretti, Gustavo Ferreira Alves, Alessia Sofia Cento, Claudia Fornelli, Federica Dal Bello, Chiara Ferraris, Luca Goitre, Andrea Perrelli, Saverio Francesco Retta
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 19; Pages: 11151
KRIT1 loss-of-function mutations underlie the pathogenesis of Cerebral Cavernous Malformation (CCM), a major vascular disease affecting the central nervous system (CNS). However, KRIT1 is also expressed outside the CNS and modulates key regulators of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d36f5685d298a6106f962ddd6b66b934
https://hdl.handle.net/2318/1881438
https://hdl.handle.net/2318/1881438
Autor:
Andrea, Moglia, Cinzia, Comino, Sergio, Lanteri, Ric, de Vos, Pieter, de Waard, Teris A., van Beek, Luca, Goitre, Saverio Francesco, Retta, Jules, Beekwilder
Publikováno v:
In Metabolic Engineering 2010 12(3):223-232
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2152
The development of distinct cellular and animal models has allowed the identification and characterization of molecular mechanisms underlying the pathogenesis of cerebral cavernous malformation (CCM) disease. This is a major cerebrovascular disorder
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::54caa4dcdd4df2eea8a5a20b0650b914
https://pubmed.ncbi.nlm.nih.gov/32524551
https://pubmed.ncbi.nlm.nih.gov/32524551
Publikováno v:
Methods in Molecular Biology ISBN: 9781071606391
The development of distinct cellular and animal models has allowed the identification and characterization of molecular mechanisms underlying the pathogenesis of cerebral cavernous malformation (CCM) disease. This is a major cerebrovascular disorder
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6261686aea5000653ef5df23e8273b8
http://hdl.handle.net/2318/1742680
http://hdl.handle.net/2318/1742680
Autor:
Anna Maria Salzano, Andrea Moglia, Andrea Scaloni, Andrea Perrelli, Saverio Francesco Retta, Luca Goitre
Publikováno v:
Oxidative medicine and cellular longevity (Online) 2018 (2018). doi:10.1155/2018/6015351
info:cnr-pdr/source/autori:Perrelli A.; Goitre L.; Salzano A.M.; Moglia A.; Scaloni A.; Retta S.F./titolo:Biological activities, health benefits, and therapeutic properties of avenanthramides: From skin protection to prevention and treatment of cerebrovascular diseases/doi:10.1155%2F2018%2F6015351/rivista:Oxidative medicine and cellular longevity (Online)/anno:2018/pagina_da:/pagina_a:/intervallo_pagine:/volume:2018
Oxidative Medicine and Cellular Longevity, Vol 2018 (2018)
info:cnr-pdr/source/autori:Perrelli A.; Goitre L.; Salzano A.M.; Moglia A.; Scaloni A.; Retta S.F./titolo:Biological activities, health benefits, and therapeutic properties of avenanthramides: From skin protection to prevention and treatment of cerebrovascular diseases/doi:10.1155%2F2018%2F6015351/rivista:Oxidative medicine and cellular longevity (Online)/anno:2018/pagina_da:/pagina_a:/intervallo_pagine:/volume:2018
Oxidative Medicine and Cellular Longevity, Vol 2018 (2018)
Oat (Avena sativa) is a cereal known since antiquity as a useful grain with abundant nutritional and health benefits. It contains distinct molecular components with high antioxidant activity, such as tocopherols, tocotrienols, and flavanoids. In addi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10c79243083a26617aca05ba648be342
https://doi.org/10.1155/2018/6015351
https://doi.org/10.1155/2018/6015351
Autor:
Simona Delle Monache, Stefania Pizzimenti, Adriano Angelucci, Vincenzo Nicola Talesa, Martina Daga, Andrea Perrelli, Paola Cassoni, Lorenza Trabalzini, Eliana Trapani, Giuseppina Barrera, Luca Goitre, Saverio Francesco Retta, Cinzia Antognelli
Publikováno v:
Free Radical Biology & Medicine
KRIT1 (CCM1) is a disease gene responsible for Cerebral Cavernous Malformations (CCM), a major cerebrovascular disease of proven genetic origin affecting 0.3–0.5% of the population. Previously, we demonstrated that KRIT1 loss-of-function is associa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9626ca3388471d5ac6e4cae96d0dfe5e
http://hdl.handle.net/2318/1663006
http://hdl.handle.net/2318/1663006