Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Luca Gerosa"'
Autor:
Caitlin E. Mills, Kartik Subramanian, Marc Hafner, Mario Niepel, Luca Gerosa, Mirra Chung, Chiara Victor, Benjamin Gaudio, Clarence Yapp, Ajit J. Nirmal, Nicholas Clark, Peter K. Sorger
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
It is currently difficult to perform accurate single-cell assays in 384-well plates. Here the authors report Dye Drop which uses sequential density displacement and microscopy for multi-step assays on cells, and use this to collect single-cell dose-r
Externí odkaz:
https://doaj.org/article/fd5702d7273c4618abdb7be6d446e8fd
Autor:
Jia-Yun Chen, Clemens Hug, José Reyes, Chengzhe Tian, Luca Gerosa, Fabian Fröhlich, Bas Ponsioen, Hugo J.G. Snippert, Sabrina L. Spencer, Ashwini Jambhekar, Peter K. Sorger, Galit Lahav
Publikováno v:
Cell Reports, Vol 42, Iss 3, Pp 112252- (2023)
Summary: Oncogene-induced senescence is a phenomenon in which aberrant oncogene expression causes non-transformed cells to enter a non-proliferative state. Cells undergoing oncogenic induction display phenotypic heterogeneity, with some cells senesci
Externí odkaz:
https://doaj.org/article/36dd9f1bb081478bb61988811e5931cb
Mechanistic model of MAPK signaling reveals how allostery and rewiring contribute to drug resistance
Publikováno v:
Molecular Systems Biology, Vol 19, Iss 2, Pp n/a-n/a (2023)
Abstract BRAF is prototypical of oncogenes that can be targeted therapeutically and the treatment of BRAFV600E melanomas with RAF and MEK inhibitors results in rapid tumor regression. However, drug‐induced rewiring generates a drug adapted state th
Externí odkaz:
https://doaj.org/article/69084d89f94441bbac55f795548a3834
Autor:
Karl Kochanowski, Luca Gerosa, Simon F Brunner, Dimitris Christodoulou, Yaroslav V Nikolaev, Uwe Sauer
Publikováno v:
Molecular Systems Biology, Vol 13, Iss 1, Pp n/a-n/a (2017)
Abstract Transcription networks consist of hundreds of transcription factors with thousands of often overlapping target genes. While we can reliably measure gene expression changes, we still understand relatively little why expression changes the way
Externí odkaz:
https://doaj.org/article/8836ea3be6c6490591a7408cefebd07e
Elucidation of Genetic Interactions in the Yeast GATA-Factor Network Using Bayesian Model Selection.
Autor:
Andreas Milias-Argeitis, Ana Paula Oliveira, Luca Gerosa, Laura Falter, Uwe Sauer, John Lygeros
Publikováno v:
PLoS Computational Biology, Vol 12, Iss 3, p e1004784 (2016)
Understanding the structure and function of complex gene regulatory networks using classical genetic assays is an error-prone procedure that frequently generates ambiguous outcomes. Even some of the best-characterized gene networks contain interactio
Externí odkaz:
https://doaj.org/article/d8f1946b560241f1a2341b6095dcd1bc
Publikováno v:
Molecular Systems Biology, Vol 9, Iss 1, Pp n/a-n/a (2013)
Gene expression is regulated by specific transcriptional circuits but also by the global expression machinery as a function of growth. Simultaneous specific and global regulation thus constitutes an additional—but often neglected—layer of complex
Externí odkaz:
https://doaj.org/article/d2e05f538e2f43a8ba409bbf5e49a2d2
Autor:
Nicholas P. D. Liau, Matthew C. Johnson, Saeed Izadi, Luca Gerosa, Michal Hammel, John M. Bruning, Timothy J. Wendorff, Wilson Phung, Sarah G. Hymowitz, Jawahar Sudhamsu
Publikováno v:
Nature, vol 609, iss 7926
The RAS–RAF pathway is one of the most commonly dysregulated in human cancers1–3. Despite decades of study, understanding of the molecular mechanisms underlying dimerization and activation4 of the kinase RAF remains limited. Recent structures of
Mechanistic model of MAPK signaling reveals how allostery and rewiring contribute to drug resistance
Publikováno v:
Molecular Systems Biology. 19
Publikováno v:
Molecular Cancer Research. 21:PR02-PR02
The RAS-RAF pathway is one of the most commonly dysregulated in human cancers. The activation of this pathway is tightly regulated with appropriate spatial and temporal signaling cues. The central step in activation of this pathway is the dimerizatio
Autor:
Caitlin Mills, Kartik Subramanian, Marc Hafner, Mario Niepel, Luca Gerosa, Mirra Chung, Chiara Victor, Benjamin Gaudio, Clarence Yapp, Ajit Johnson Nirmal, Nicholas Clark, Peter Sorger
High-throughput measurement of cells perturbed using libraries of small molecules, gene knockouts, or different microenvironmental factors is a key step in functional genomics and pre-clinical drug discovery. However, it remains difficult to perform
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca4c87a1f1309ca57bb83ba37f2ab55c
https://doi.org/10.21203/rs.3.rs-1813095/v1
https://doi.org/10.21203/rs.3.rs-1813095/v1