Zobrazeno 1 - 10
of 188
pro vyhledávání: '"Luca Gentilucci"'
Publikováno v:
Biomedicines, Vol 12, Iss 2, p 316 (2024)
Integrins are heterodimeric cell-surface receptors that regulate cell–cell adhesion and cellular functions through bidirectional signaling. On the other hand, anomalous trafficking of integrins is also implicated in severe pathologies as cancer, th
Externí odkaz:
https://doaj.org/article/de44bb42e1ef477d98086360e5f0f973
Autor:
Monica Baiula, Michele Anselmi, Francesco Musiani, Alessia Ghidini, Jacopo Carbone, Alberto Caligiana, Andrea Maurizio, Santi Spampinato, Luca Gentilucci
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 11, p 9588 (2023)
Integrin receptors mediate cell–cell interactions via the recognition of cell-adhesion glycoproteins, as well as via the interactions of cells with proteins of the extracellular matrix, and upon activation they transduce signals bi-directionally ac
Externí odkaz:
https://doaj.org/article/e726fd225cd04d1e9c1551e64dcfb911
Autor:
Federica Santino, Luca Gentilucci
Publikováno v:
Molecules, Vol 28, Iss 1, p 346 (2023)
The κ-opioid receptor (KOR) has recently emerged as an alternative therapeutic target for the development of pain medications, without deleterious side effects associated with the μ-opioid receptor (MOR). However, modulation of KOR is currently und
Externí odkaz:
https://doaj.org/article/6b8abe0d3cba4ca983aca81554a387c9
Autor:
Junwei Zhao, Jacopo Carbone, Giovanna Farruggia, Anna Janecka, Luca Gentilucci, Natalia Calonghi
Publikováno v:
Molecules, Vol 28, Iss 1, p 265 (2022)
Indoles constitute a large family of heterocyclic compounds widely occurring in nature which are present in a number of bioactive natural and synthetic compounds, including anticancer agents or atypical opioid agonists. As a result, exponential incre
Externí odkaz:
https://doaj.org/article/054dd5cb72444dc4980723e02a4b686f
Autor:
Karol Wtorek, Alessia Ghidini, Luca Gentilucci, Anna Adamska-Bartłomiejczyk, Justyna Piekielna-Ciesielska, Chiara Ruzza, Chiara Sturaro, Girolamo Calò, Stefano Pieretti, Alicja Kluczyk, John McDonald, David G. Lambert, Anna Janecka
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 20, p 12700 (2022)
Recently, mixed opioid/NOP agonists came to the spotlight for their favorable functional profiles and promising outcomes in clinical trials as novel analgesics. This study reports on two novel chimeric peptides incorporating the fragment Tyr-c[D-Lys-
Externí odkaz:
https://doaj.org/article/819627af45404fe79afa47b69584b618
Publikováno v:
Molecules, Vol 27, Iss 20, p 6884 (2022)
Molecular docking is a key method for structure-based drug design used to predict the conformations assumed by small drug-like ligands when bound to their target. However, the evaluation of molecular docking studies can be hampered by the lack of a f
Externí odkaz:
https://doaj.org/article/410f4dcebe1a4fcaba9c542a911e0c27
Autor:
Monica Baiula, Alberto Caligiana, Andrea Bedini, Junwei Zhao, Federica Santino, Martina Cirillo, Luca Gentilucci, Daria Giacomini, Santi Spampinato
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2021)
Age-related macular degeneration (AMD) is a complex multifactorial degenerative disease that leads to irreversible blindness. AMD affects the macula, the central part of the retina responsible for sharp central vision. Retinal pigment epithelium (RPE
Externí odkaz:
https://doaj.org/article/b3224316dacc481b886949952b698e7b
Autor:
Andrea Bedini, Lorenzo Di Cesare Mannelli, Laura Micheli, Monica Baiula, Gabriela Vaca, Rossella De Marco, Luca Gentilucci, Carla Ghelardini, Santi Spampinato
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Kappa opioid receptor (KOPr) agonists represent alternative analgesics for their low abuse potential, although relevant adverse effects have limited their clinical use. Functionally selective KOPr agonists may activate, in a pathway-specific manner,
Externí odkaz:
https://doaj.org/article/c5745159e6ba41cc97ba48ac3f15a654
Autor:
Michele Anselmi, Monica Baiula, Federica Santino, Junwei Zhao, Santi Spampinato, Natalia Calonghi, Luca Gentilucci
Publikováno v:
Biomedicines, Vol 9, Iss 11, p 1737 (2021)
Arg-Gly-Asp (RGD)-binding integrins, e.g., αvβ3, αvβ1, αvβ5 integrins, are currently regarded as privileged targets for the delivery of diagnostic and theranostic agents, especially in cancer treatment. In contrast, scarce attention has been pa
Externí odkaz:
https://doaj.org/article/faf7fdc793aa4313b46478b618b4081c
Autor:
Nicola Zanna, Stefano Focaroli, Andrea Merlettini, Luca Gentilucci, Gabriella Teti, Mirella Falconi, Claudia Tomasini
Publikováno v:
ACS Omega, Vol 2, Iss 5, Pp 2374-2381 (2017)
Externí odkaz:
https://doaj.org/article/ae487902fd364247a7ed10c2df14880d