Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Luca F, Raveglia"'
Autor:
Caterina Virginio, Laura Aldegheri, Selena Nola, Daniela Brodbeck, Laurent Brault, Luca F. Raveglia, Alessio Barilli, Mark Sabat, Richard Myers
Publikováno v:
SLAS Discovery, Vol 27, Iss 1, Pp 55-64 (2022)
Transient Receptor Potential Melastatin 5 (TRPM5) is an intracellular calcium-activated cation-selective ion channel expressed in a variety of cell types. Dysfunction of this channel has recently been implied in a range of disease states including di
Externí odkaz:
https://doaj.org/article/4cf64e986b4845aa93cac6e858d386ee
Autor:
Elisabetta Armani, Andrea Rizzi, Nicolò Iotti, Francesca Saccani, Maria Rosaria Di Lascia, Laura Tigli, Alice Pappani, Gessica Marchini, Annalisa Murgo, Anna Maria Capelli, Maurizio Delcanale, Paola Puccini, Gino Villetti, Maurizio Civelli, Claudia Beato, Marta Giuliani, Claudia Mundi, Francesca Murarolli, Mafalda Pagano, Luca F. Raveglia, Rosaria Remelli, Gabriele Amari
Publikováno v:
Journal of Medicinal Chemistry. 66:5622-5656
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::89b17dfe06b068e161a65cbfe2796689
https://doi.org/10.1021/acs.jmedchem.2c02087
https://doi.org/10.1021/acs.jmedchem.2c02087
Autor:
Alessio, Barilli, Laura, Aldegheri, Federica, Bianchi, Laurent, Brault, Daniela, Brodbeck, Laura, Castelletti, Aldo, Feriani, Iain, Lingard, Richard, Myers, Selena, Nola, Laura, Piccoli, Daniela, Pompilio, Luca F, Raveglia, Cristian, Salvagno, Sabrina, Tassini, Caterina, Virginio, Mark, Sabat
Publikováno v:
Journal of medicinal chemistry. 64(9)
Transient receptor potential cation channel subfamily M member 5 (TRPM5) is a nonselective monovalent cation channel activated by intracellular Ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d619050999d16fbf323a8d84594fd590
https://pubmed.ncbi.nlm.nih.gov/33890770
https://pubmed.ncbi.nlm.nih.gov/33890770
Autor:
Andrew D. Westwell, Ge Li, Douglas S. Johnson, Sylvain Cottens, Luca F. Raveglia, Mike Eaton, Joseph P. Fuhr, Graeme M. Robertson, Steward Geary
Publikováno v:
Future Medicinal Chemistry. 3:1863-1872
The pharmaceutical industry is facing numerous, well-documented challenges – from the effects of patent expirations to high attrition rates in the drug-development pipeline. Future Medicinal Chemistry has invited a group of leaders from academia an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5210f8a39d2a922dfe3bafdcb2dd927d
https://doi.org/10.4155/fmc.11.145
https://doi.org/10.4155/fmc.11.145
Publikováno v:
Expert Opinion on Therapeutic Patents. 10:939-960
This review addresses the recent highlights and progress made in the neurokinin-3 (NK-3) receptor area since the last update, provided in this journal in 1997. Whereas in the neurokinin-1 (NK-1) and neurokinin-2 (NK-2) biological areas literature inf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::19bf8d341c380d1a484312c8e7d82342
https://doi.org/10.1517/13543776.10.6.939
https://doi.org/10.1517/13543776.10.6.939
Autor:
Giorgio Pifferi, Luca F. Raveglia, Giuseppe Giardina, Douglas W. P. Hay, Davide Graziani, Renzo Mena, Marco Artico, Mark A. Luttmann, Mauro Vitali
Publikováno v:
European Journal of Medicinal Chemistry. 34:825-835
To rapidly gain information on structure-activity relationship (SAR) requirements of the human neurokinin 3 (hNK-3) receptor antagonist SR 142801, an indexed combinatorial library was synthesised in solution and screened on the hNK-3 receptor. SAR co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::837163fabc6273ee73fd2b4aeff60d93
https://doi.org/10.1016/s0223-5234(99)00210-x
https://doi.org/10.1016/s0223-5234(99)00210-x
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:2967-2972
Structure Activity Relationship and docking studies focused on the role of the non-aromatic ° address in a novel class of potent and selective ° ligands, pyrrolooctahydroisoquinolines, are discussed.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5035fa93bae71bb859d4f20ae5baac7e
https://doi.org/10.1016/s0960-894x(97)10119-6
https://doi.org/10.1016/s0960-894x(97)10119-6
Autor:
Douglas W. P. Hay, Vittorio Vecchietti, Carlo Farina, Mark A. Luttmann, Henry M. Sarau, Roberto Rigolio, Andrew D. Medhurst, Luca F. Raveglia, Dulcie B. Schmidt, Giuseppe Giardina, Mario Grugni
Publikováno v:
Journal of Medicinal Chemistry. 40:1794-1807
A novel class of potent and selective non-peptide neurokinin-3 (NK-3) receptor antagonists, featuring the 4-quinolinecarboxamide framework, has been designed based upon chemically diverse NK-1 receptor antagonists. The novel compounds 33-76, prompted
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::343b09fd7229d428c0da78e9eb9e3aec
https://doi.org/10.1021/jm960818o
https://doi.org/10.1021/jm960818o
Autor:
Giuseppe Am Giardina, Luca F. Raveglia
Publikováno v:
Expert Opinion on Therapeutic Patents. 7:307-323
Until late 1994, research on the neurokinin-3 (NK3) receptor, compared with that on neurokinin-1 (NK1) and neurokinin-2 (NK2) receptors, received little attention, due, to a large extent, to the absence of potent and selective non-peptide NK3 recepto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::681e77b409df7a07931bfe3325d1653d
https://doi.org/10.1517/13543776.7.4.307
https://doi.org/10.1517/13543776.7.4.307
Autor:
Dulcie B. Schmidt, Andrew D. Medhurst, Marco Vassallo, Mario Grugni, Douglas W. P. Hay, Giuseppe Giardina, Carlo Farina, Henry M. Sarau, Vittorio Vecchietti, Roberto Rigolio, James J. Foley, Luca F. Raveglia
Publikováno v:
Journal of Medicinal Chemistry. 39:2281-2284
Pharmacological and molecular biological studies indicate the existence of at least three human tachykinin receptor subtypes, designated neurokinin-1 (NK-1), neurokinin-2 (NK-2), and neurokinin-3 (NK-3),1-3 which belong to the superfamily of G-protei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae45e5db63c304eaccf7c5c47403870c
https://doi.org/10.1021/jm9602423
https://doi.org/10.1021/jm9602423