Antibody-Based In Vivo Imaging of Central Nervous System Targets—Evaluation of a Pretargeting Approach Utilizing a TCO-Conjugated Brain Shuttle Antibody and Radiolabeled Tetrazines

Autor: Christoph Bredack, Martin R. Edelmann, Edilio Borroni, Luca C. Gobbi, Michael Honer

Publikováno v: Pharmaceuticals, Vol 15, Iss 12, p 1445 (2022)

Bioorthogonal pretargeted imaging using the inverse-electron-demand Diels–Alder (IEDDA) reaction between a tetrazine (Tz) and a trans-cyclooctene (TCO) represents an attractive strategy for molecular imaging via antibodies. The advantages of using

Externí odkaz: https://doaj.org/article/172d1d7a84e54fd7875847c4caebf505

Discovery, synthesis and evaluation of novel reversible monoacylglycerol lipase radioligands bearing a morpholine-3-one scaffold

Autor: Yingfang He, Luca C. Gobbi, Adrienne Müller Herde, Didier Rombach, Martin Ritter, Bernd Kuhn, Matthias B. Wittwer, Dominik Heer, Benoit Hornsperger, Charles Bell, Fionn O'Hara, Jörg Benz, Michael Honer, Claudia Keller, Ludovic Collin, Hans Richter, Roger Schibli, Uwe Grether, Linjing Mu

Publikováno v: Nuclear Medicine and Biology, 108-109

Monoacylglycerol lipase (MAGL) is a serine hydrolase that plays an important role in the endocannabinoid degradation in the brain. It has recently emerged as a promising therapeutic target in the treatment of neuroinflammatory and neurodegenerative d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce52a586caa948df1c940c2253b3a130
https://hdl.handle.net/20.500.11850/536205

Multi-parameter optimization: Development of a morpholin-3-one derivative with an improved kinetic profile for imaging monoacylglycerol lipase in the brain

Autor: Yingfang He, Uwe Grether, Marco F. Taddio, Carla Meier, Claudia Keller, Martin R. Edelmann, Michael Honer, Sylwia Huber, Matthias B. Wittwer, Dominik Heer, Hans Richter, Ludovic Collin, Melanie N. Hug, Manuel Hilbert, Annemarieke G.J. Postmus, Anna Floor Stevens, Mario van der Stelt, Stefanie D. Krämer, Roger Schibli, Linjing Mu, Luca C. Gobbi

Publikováno v: European Journal of Medicinal Chemistry, 243:114750. ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
European Journal of Medicinal Chemistry, 243

Monoacylglycerol lipase (MAGL) is a gatekeeper in regulating endocannabinoid signaling and has gained substantial attention as a therapeutic target for neurological disorders. We recently discovered a morpholin-3-one derivative as a novel scaffold fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e3c55a40e57837b88082305c6a4d833
https://doi.org/10.1016/j.ejmech.2022.114750