Zobrazeno 1 - 10
of 147
pro vyhledávání: '"Luca Businaro"'
Autor:
Adriana Rosa Gambardella, Caterina Antonucci, Cristiana Zanetti, Francesco Noto, Sara Andreone, Davide Vacca, Valentina Pellerito, Chiara Sicignano, Giuseppe Parrottino, Valentina Tirelli, Antonella Tinari, Mario Falchi, Adele De Ninno, Luca Businaro, Stefania Loffredo, Gilda Varricchi, Claudio Tripodo, Claudia Afferni, Isabella Parolini, Fabrizio Mattei, Giovanna Schiavoni
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-25 (2024)
Abstract Immune cell-derived extracellular vesicles (EV) affect tumor progression and hold promise for therapeutic applications. Eosinophils are major effectors in Th2-related pathologies recently implied in cancer. Here, we evaluated the anti-tumor
Externí odkaz:
https://doaj.org/article/9b0f9646ff2d4fdcab61db2ede19e22c
Autor:
Valeria Lucarini, Ombretta Melaiu, Silvia D’Amico, Fabio Pastorino, Patrizia Tempora, Marco Scarsella, Marco Pezzullo, Adele De Ninno, Valentina D’Oria, Michele Cilli, Laura Emionite, Paola Infante, Lucia Di Marcotullio, Maria Antonietta De Ioris, Giovanni Barillari, Rita Alaggio, Luca Businaro, Mirco Ponzoni, Franco Locatelli, Doriana Fruci
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 41, Iss 1, Pp 1-19 (2022)
Abstract Background Poor infiltration of functioning T cells renders tumors unresponsive to checkpoint-blocking immunotherapies. Here, we identified a combinatorial in situ immunomodulation strategy based on the administration of selected immunogenic
Externí odkaz:
https://doaj.org/article/7da718b9d0384f1794918c8d3fdad88d
Autor:
Luigi Racioppi, Erik R. Nelson, Wei Huang, Debarati Mukherjee, Scott A. Lawrence, William Lento, Anna Maria Masci, Yiquin Jiao, Sunghee Park, Brian York, Yaping Liu, Amy E. Baek, David H. Drewry, William J. Zuercher, Francesca R. Bertani, Luca Businaro, Joseph Geradts, Allison Hall, Anthony R. Means, Nelson Chao, Ching-yi Chang, Donald P. McDonnell
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Calcium/calmodulin-dependent kinase kinase 2 (CaMKK2) is highly expressed in several cancers. Here the authors investigate the role of CaMKK2 expression in the tumour microenvironment and show that CaMKK2 expression in tumour-associated macrophages p
Externí odkaz:
https://doaj.org/article/072c9c0330034d37ac61bcbbffebcda1
Autor:
Fabrizio Mattei, Sara Andreone, Arianna Mencattini, Adele De Ninno, Luca Businaro, Eugenio Martinelli, Giovanna Schiavoni
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
Oncoimmunology represents a biomedical research discipline coined to study the roles of immune system in cancer progression with the aim of discovering novel strategies to arm it against the malignancy. Infiltration of immune cells within the tumor m
Externí odkaz:
https://doaj.org/article/ae0bb423a6994aaba6b15af575d24952
Autor:
Francesca R. Bertani, Pamela Mozetic, Marco Fioramonti, Michele Iuliani, Giulia Ribelli, Francesco Pantano, Daniele Santini, Giuseppe Tonini, Marcella Trombetta, Luca Businaro, Stefano Selci, Alberto Rainer
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
Abstract The possibility of detecting and classifying living cells in a label-free and non-invasive manner holds significant theranostic potential. In this work, Hyperspectral Imaging (HSI) has been successfully applied to the analysis of macrophagic
Externí odkaz:
https://doaj.org/article/1d75aee3c71e4d898809e9c4699d7677
Autor:
Alessio Gizzi, Sara Maria Giannitelli, Marcella Trombetta, Christian Cherubini, Simonetta Filippi, Adele De Ninno, Luca Businaro, Annamaria Gerardino, Alberto Rainer
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract This paper describes the computationally informed design and experimental validation of a microfluidic chip device with multi-axial stretching capabilities. The device, based on PDMS soft-lithography, consisted of a thin porous membrane, mou
Externí odkaz:
https://doaj.org/article/6f91ed0ec9124234b69f86cda64b0cab
Autor:
Stefania Parlato, Adele De Ninno, Rosa Molfetta, Elena Toschi, Debora Salerno, Arianna Mencattini, Giulia Romagnoli, Alessandra Fragale, Lorenzo Roccazzello, Maria Buoncervello, Irene Canini, Enrico Bentivegna, Mario Falchi, Francesca Romana Bertani, Annamaria Gerardino, Eugenio Martinelli, Corrado Natale, Rossella Paolini, Luca Businaro, Lucia Gabriele
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-16 (2017)
Abstract Immunotherapy efficacy relies on the crosstalk within the tumor microenvironment between cancer and dendritic cells (DCs) resulting in the induction of a potent and effective antitumor response. DCs have the specific role of recognizing canc
Externí odkaz:
https://doaj.org/article/370bcc5595844c69b7a43669228ca030
Autor:
Arianna Mencattini, Fabrizio Mattei, Giovanna Schiavoni, Annamaria Gerardino, Luca Businaro, Corrado Di Natale, Eugenio Martinelli
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
The increasing interest for microfluidic devices in medicine and biology has opened the way to new time-lapse microscopy era where the amount of images and their acquisition time will become crucial. In this optic, new data analysis algorithms have t
Externí odkaz:
https://doaj.org/article/013138a9c26548e2914c5d778781e48e
Autor:
Marie Nguyen, Adele De Ninno, Arianna Mencattini, Fanny Mermet-Meillon, Giulia Fornabaio, Sophia S. Evans, Mélissande Cossutta, Yasmine Khira, Weijing Han, Philémon Sirven, Floriane Pelon, Davide Di Giuseppe, Francesca Romana Bertani, Annamaria Gerardino, Ayako Yamada, Stéphanie Descroix, Vassili Soumelis, Fatima Mechta-Grigoriou, Gérard Zalcman, Jacques Camonis, Eugenio Martinelli, Luca Businaro, Maria Carla Parrini
Publikováno v:
Cell Reports, Vol 25, Iss 13, Pp 3884-3893.e3 (2018)
Summary: A major challenge in cancer research is the complexity of the tumor microenvironment, which includes the host immunological setting. Inspired by the emerging technology of organ-on-chip, we achieved 3D co-cultures in microfluidic devices (in
Externí odkaz:
https://doaj.org/article/1348722c708442c9936e214684b50064
Autor:
Sara Andreone, Francesca Spadaro, Carla Buccione, Jacopo Mancini, Antonella Tinari, Paola Sestili, Adriana Rosa Gambardella, Valeria Lucarini, Giovanna Ziccheddu, Isabella Parolini, Cristiana Zanetti, Maria Teresa D’Urso, Adele De Ninno, Luca Businaro, Claudia Afferni, Fabrizio Mattei, Giovanna Schiavoni
Publikováno v:
Cancers, Vol 11, Iss 11, p 1664 (2019)
Eosinophils are major effectors of Th2-related pathologies, frequently found infiltrating several human cancers. We recently showed that eosinophils play an essential role in anti-tumor responses mediated by immunotherapy with the ‘alarmin’ inter
Externí odkaz:
https://doaj.org/article/e493adb848e0483c913a414eb6b194aa