Hematopoietic reconstitution dynamics of mobilized- and bone marrow-derived human hematopoietic stem cells after gene therapy

Autor: Serena Scala, Francesca Ferrua, Luca Basso-Ricci, Francesca Dionisio, Maryam Omrani, Pamela Quaranta, Raisa Jofra Hernandez, Luca Del Core, Fabrizio Benedicenti, Ilaria Monti, Stefania Giannelli, Federico Fraschetta, Silvia Darin, Elena Albertazzi, Stefania Galimberti, Eugenio Montini, Andrea Calabria, Maria Pia Cicalese, Alessandro Aiuti

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)

Abstract Mobilized peripheral blood is increasingly used instead of bone marrow as a source of autologous hematopoietic stem/progenitor cells for ex vivo gene therapy. Here, we present an unplanned exploratory analysis evaluating the hematopoietic re

Externí odkaz: https://doaj.org/article/e8cf85c9c38a471eb61bf3b7cd0330e9

Oncogene-induced senescence in hematopoietic progenitors features myeloid restricted hematopoiesis, chronic inflammation and histiocytosis

Autor: Riccardo Biavasco, Emanuele Lettera, Kety Giannetti, Diego Gilioli, Stefano Beretta, Anastasia Conti, Serena Scala, Daniela Cesana, Pierangela Gallina, Margherita Norelli, Luca Basso-Ricci, Attilio Bondanza, Giulio Cavalli, Maurilio Ponzoni, Lorenzo Dagna, Claudio Doglioni, Alessandro Aiuti, Ivan Merelli, Raffaella Di Micco, Eugenio Montini

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)

BRAF-MAPK activating mutations are reported in histiocytoses—hematological neoplasms with widespread pro-inflammatory myeloid cells. Here, the authors show that an activating mutant BRAF in haematopoietic stem and progenitor cells causes an oncogen

Externí odkaz: https://doaj.org/article/fee49380e85c4d6fa86a0b00aa340aa0

Expanded circulating hematopoietic stem/progenitor cells as novel cell source for the treatment of TCIRG1 osteopetrosis

Autor: Valentina Capo, Sara Penna, Ivan Merelli, Matteo Barcella, Serena Scala, Luca Basso-Ricci, Elena Draghici, Eleonora Palagano, Erika Zonari, Giacomo Desantis, Paolo Uva, Roberto Cusano, Lucia Sergi Sergi, Laura Crisafulli, Despina Moshous, Polina Stepensky, Katarzyna Drabko, Zühre Kaya, Ekrem Unal, Alper Gezdirici, Giuseppe Menna, Marta Serafini, Alessandro Aiuti, Silvia Laura Locatelli, Carmelo Carlo-Stella, Ansgar S. Schulz, Francesca Ficara, Cristina Sobacchi, Bernhard Gentner, Anna Villa

Publikováno v: Haematologica, Vol 106, Iss 1 (2020)

Allogeneic hematopoietic stem cell transplantation is the treatment of choice for autosomal recessive osteopetrosis caused by defects in the TCIRG1 gene. Despite recent progress in conditioning, a relevant number of patients are not eligible for allo

Externí odkaz: https://doaj.org/article/41f41f3cd71f426da4e55083438ac158

Expanded circulating hematopoietic stem/progenitor cells as novel cell source for the treatment of TCIRG1 osteopetrosis

Autor: Lucia Sergi Sergi, Polina Stepensky, Roberto Cusano, Serena Scala, Alper Gezdirici, Paolo Uva, Cristina Sobacchi, Bernhard Gentner, Eleonora Palagano, Ekrem Unal, Valentina Capo, Elena Draghici, Alessandro Aiuti, Ivan Merelli, Silvia L. Locatelli, Zühre Kaya, Carmelo Carlo-Stella, Ansgar Schulz, Laura Crisafulli, Luca Basso-Ricci, Francesca Ficara, Marta Serafini, Giacomo Desantis, Despina Moshous, Erika Zonari, Sara Penna, Giuseppe Menna, Matteo Barcella, Katarzyna Drabko, Anna Villa

Publikováno v: Haematologica
Haematologica (Roma) (2020).
info:cnr-pdr/source/autori:Valentina Capo1, Sara Penna1, Ivan Merelli2, Matteo Barcella1, Serena Scala1, Luca Basso-Ricci1, Elena Draghici1, Eleonora Palagano3, Erika Zonari1, Giacomo Desantis1, Paolo Uva4, Roberto Cusano4, Lucia Sergi Sergi1, Laura Crisafulli3, Despina Moshous5, Polina Stepensky6, Katarzyna Drabko7, Zühre Kaya8, Ekrem Unal9, Alper Gezdirici10, Giuseppe Menna11, Marta Serafini12, Alessandro Aiuti1, Silvia Laura Locatelli13, Carmelo Carlo-Stella13, Ansgar S. Schulz14, Francesca Ficara3, Cristina Sobacchi3, Bernhard Gentner1 and Anna Villa1/titolo:Expanded circulating hematopoietic stem%2Fprogenitor cells as novel cell source for the treatment of TCIRG1 osteopetrosis/doi:/rivista:Haematologica (Roma)/anno:2020/pagina_da:/pagina_a:/intervallo_pagine:/volume

Allogeneic hematopoietic stem cell transplantation is the treatment of choice for autosomal recessive osteopetrosis caused by defects in the TCIRG1 gene. Despite recent progress in conditioning, an important number of patients are not eligible for al

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5183ae0f8b8aad634203110d46555d46
https://doi.org/10.3324/haematol.2019.238261

A Novel Assay in Whole Blood Demonstrates Restoration of Mitochondrial Activity in Phagocytes After Successful HSCT in Hyperinflamed X-Linked Chronic Granulomatous Disease

Autor: Maddalena Migliavacca, Luca Basso Ricci, Giada Farinelli, Valeria Calbi, Francesca Tucci, Federica Barzaghi, Francesca Ferrua, Maria Pia Cicalese, Silvia Darin, Lina Raffaella Barzaghi, Fabio Giglio, Jacopo Peccatori, Francesca Fumagalli, Roberto Nicoletti, Stefania Giannelli, Claudia Sartirana, Alessandro Bandiera, Maria Esposito, Raffaella Milani, Benedetta Mazzi, Andrea Finocchi, Sarah Marktel, Andrea Assanelli, Franco Locatelli, Fabio Ciceri, Alessandro Aiuti, Maria Ester Bernardo

X-linked chronic granulomatous disease is a rare disease caused by mutations in the CYBB gene. While more extensive knowledge is available on genetics, pathogenesis, and possible therapeutic options, mitochondrial activity and its implications on pat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::499e30178a9e4596e0ceb7e15588e1d8
https://hdl.handle.net/10807/228357