Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Luca Arista"'
Autor:
Chris Roberts, George L. Trainor, Matt Lucas, Luca Arista, Nigel J. Waters, Iwona Wrona, Elizabeth Buck, Tai-An Lin, Darlene Romashko, Deborah Chen, Matthew O'Connor, Alexander Flohr, David R. Raleigh, Giorgio Ottaviani, Raffaele Fiorenza, Theodore Nicolaides, Tomoko Ozawa, Sara Rasmussen
Publikováno v:
Cancer Research. 81:LB140-LB140
Oncogenic EGFR mutations occur in approximately 50% of glioblastomas (GBM) and largely reside in the extracellular domain. Prior attempts to reposition current generation EGFR inhibitors to treat GBM likely failed due to poor brain penetration and an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::911562fa874222b1ecfca796f985896b
https://doi.org/10.1158/1538-7445.am2021-lb140
https://doi.org/10.1158/1538-7445.am2021-lb140
Autor:
Chris Roberts, David R. Raleigh, Giorgio Ottaviani, Tomoko Ozawa, Matthew O'Connor, Raffaele Fiorenza, Elizabeth Buck, Luca Arista, Nigel J. Waters, Theodore Nicolaides, Alexander Flohr, George L. Trainor, Sara Rasmussen, Tai-An Lin, Darlene Romashko, Matt Lucas
Publikováno v:
Neuro Oncol
EGFR mutations identified in glioblastomas (GBM) occur nearly exclusively at the allosteric extracellular domain (ECD) and constitutively activate oncogenic signaling. Despite wide success in treating tumors expressing EGFR catalytic site mutants, no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bd85c889bdb9e39960cfeae85a85f45
https://doi.org/10.1093/neuonc/noaa215.413
https://doi.org/10.1093/neuonc/noaa215.413
Autor:
Christine Guntermann, Joerg Kallen, David Orain, Klemens Hoegenauer, Klemens Kaupmann, Celine Be, Samuel Hintermann, Aude Izaac, Luca Arista
Publikováno v:
ChemMedChem. 12(13)
The T-cell-specific retinoic acid receptor (RAR)-related orphan receptor-γ (RORγt) is a key transcription factor for the production of pro-inflammatory Th17 cytokines, which are implicated in the pathogenesis of autoimmune diseases. Over the years,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::301861f967a4d252064681fb98c45cf8
https://pubmed.ncbi.nlm.nih.gov/28590087
https://pubmed.ncbi.nlm.nih.gov/28590087
Autor:
Candice Soares de Melo, Renier van der Westhuyzen, Ujjini H. Manjunatha, Luca Arista, Atica Moosa, Grant A. Boyle, Leslie J. Street, Nina Lawrence, Christel Brunschwig, Frederick A. Sirgel, Richard K. Gessner, Paul W. Smith, Colin R. Wilson, Paul D. van Helden, Mathew Njoroge, Dale Taylor, Ronnett Seldon, Kelly Chibale, Srinivasa P. S. Rao, Carmen de Kock, Digby F. Warner, Susan Winks
Publikováno v:
Journal of medicinal chemistry. 58(23)
High-throughput screening of a library of small polar molecules against Mycobacterium tuberculosis led to the identification of a phthalimide-containing ester hit compound (1), which was optimized for metabolic stability by replacing the ester moiety
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5562b30ff550b75ed442669a0d942bd
https://pubmed.ncbi.nlm.nih.gov/26551248
https://pubmed.ncbi.nlm.nih.gov/26551248
Autor:
Klemens Högenauer, Niko Schmiedeberg, José M. Carballido, B. Ganesh Bhat, Luca Arista, Deborah G. Nguyen, Rochdi Bouhelal, Gudrun Werner, Herbert Jaksche, Celine Rauld, Layla Raad
Publikováno v:
Journal of medicinal chemistry. 57(24)
GPBAR1 (also known as TGR5) is a G-protein-coupled receptor (GPCR) that triggers intracellular signals upon ligation by various bile acids. The receptor has been studied mainly for its function in energy expenditure and glucose homeostasis, and there
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff5b9bf571d51ac7870965b9be9ac63b
https://pubmed.ncbi.nlm.nih.gov/25411721
https://pubmed.ncbi.nlm.nih.gov/25411721
Publikováno v:
Tetrahedron Letters. 34:7089-7092
The unusual reactivity of t-butyl hydroperoxide under acid-catalysis allows the easy conversion of furan derivatives into 3(6H)-pyranones.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1493aa753658d80023d66b17111088d3
https://doi.org/10.1016/s0040-4039(00)61606-4
https://doi.org/10.1016/s0040-4039(00)61606-4
Publikováno v:
ChemInform. 25
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9ced852a5d33e4a8e83c5f4b65bcbfe2
https://doi.org/10.1002/chin.199405169
https://doi.org/10.1002/chin.199405169
Publikováno v:
ChemInform. 28
4 A molecular sieves catalyze the mild conversion of activated secondary alcohols into the corresponding carbonyl compounds with t-butyl hydroperoxide (TBHP).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4206e8a8d790db61c69e6726390de077
https://doi.org/10.1002/chin.199707064
https://doi.org/10.1002/chin.199707064
Autor:
Martyn D. Wood, Daniele Donati, Steve P. Watson, Claire M. Howes, Payne Andrew H, Patrick M. Woollard, Silvia Terreni, Romano Di Fabio, Ian Peter Holmes, Charlie Reavill, Andy Gribble, Angela Worby, Richard Blunt, Luca Arista, Stephen M. Blowers, Olivier Lorthioir, Dieter Hamprecht, Ian Stansfield, Fabrizio Micheli
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(6)
The identification of a highly selective D 2 partial agonist, D 3 antagonist tool molecule which demonstrates high levels of brain exposure and selectivity against an extensive range of dopamine, serotonin, adrenergic, histamine, and muscarinic recep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53d0ba34865e65682eabe24ee8d42e85
https://pubmed.ncbi.nlm.nih.gov/20153647
https://pubmed.ncbi.nlm.nih.gov/20153647
Autor:
Frank E. Blaney, Christian Heidbreder, Anna Checchia, Manolo Mugnaini, Charles R. Ashby, Romano Di-Fabio, Luca Arista, Dieter Hamprecht, Cristiana Griffante, Fabrizio Micheli, Stefano Fontana, Emiliangelo Ratti, Federica Damiani, Anna Maria Capelli, Luca Tarsi, Angela Worby, Carla Marchioro, Giovanna Tedesco, Silvia Terreni, Giorgio Bonanomi, Jacqui Piner, Gabriella Gentile, Simone Braggio
Publikováno v:
Journal of medicinal chemistry. 53(1)
The discovery of new highly potent and selective dopamine (DA) D(3) receptor antagonists has recently allowed the characterization of the DA D(3) receptor in a range of preclinical animal models of drug addiction. A novel series of 1,2,4-triazol-3-yl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1adb0710a359fa465c250c0ff4583e57
https://pubmed.ncbi.nlm.nih.gov/19891474
https://pubmed.ncbi.nlm.nih.gov/19891474