Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Luca D'Orsi"'
Autor:
Sara Magliacane Trotta, Antonio Adinolfi, Luca D’Orsi, Sonia Panico, Grazia Mercadante, Patrick Mehlen, Jayakrishna Ambati, Sandro De Falco, Valeria Tarallo
Publikováno v:
Experimental and Molecular Medicine, Vol 56, Iss 3, Pp 700-710 (2024)
Abstract Inflammation plays a crucial role in cancer progression, but the relevance of the inflammasome remains unclear. Alu RNA was the first endogenous nucleic acid shown to activate the NLRP3 (nucleotide-binding domain leucine-rich repeat containi
Externí odkaz:
https://doaj.org/article/1ba3f156c7634368afb21ebb3d75c43d
Autor:
Nunzia Pastore, Tuong Huynh, Niculin J. Herz, Alessia Calcagni’, Tiemo J. Klisch, Lorenzo Brunetti, Kangho Ho Kim, Marco De Giorgi, Ayrea Hurley, Annamaria Carissimo, Margherita Mutarelli, Niya Aleksieva, Luca D’Orsi, William R. Lagor, David D. Moore, Carmine Settembre, Milton J. Finegold, Stuart J. Forbes, Andrea Ballabio
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
The Transcription Factor EB (TFEB) is known to regulate cellular homeostasis and energy metabolism, but its role in cell fate determination in the liver is unknown. Here, the authors show that TFEB regulates the progenitor/cholangiocyte lineage and t
Externí odkaz:
https://doaj.org/article/dac8c6aa736f4598a4966ab084bf32fc
Autor:
Nicolina Cristina Sorrentino, Luca D'Orsi, Irene Sambri, Edoardo Nusco, Ciro Monaco, Carmine Spampanato, Elena Polishchuk, Paola Saccone, Elvira De Leonibus, Andrea Ballabio, Alessandro Fraldi
Publikováno v:
EMBO Molecular Medicine, Vol 5, Iss 5, Pp 675-690 (2013)
Abstract Mucopolysaccharidoses type IIIA (MPS‐IIIA) is a neurodegenerative lysosomal storage disorder (LSD) caused by inherited defects of the sulphamidase gene. Here, we used a systemic gene transfer approach to demonstrate the therapeutic efficac
Externí odkaz:
https://doaj.org/article/3506ff9785df4b85a417ef12e6d85355
Autor:
Tuong Huynh, Alessia Calcagni, Ayrea Hurley, Milton J. Finegold, Stuart J. Forbes, Nunzia Pastore, William R. Lagor, Luca D’Orsi, Carmine Settembre, Niculin J. Herz, Marco De Giorgi, Tiemo J. Klisch, Lorenzo Brunetti, David D. Moore, Margherita Mutarelli, Andrea Ballabio, Niya Aleksieva, Annamaria Carissimo, Kangho Ho Kim
Publikováno v:
Pastore, N, Huynh, T, Herz, N J, Calcagni, A, Klisch, T J, Brunetti, L, Kim, K H, De Giorgi, M, Hurley, A, Carissimo, A, Mutarelli, M, Aleksieva, N, D'Orsi, L, Lagor, W R, Moore, D D, Settembre, C, Finegold, M J, Forbes, S & Ballabio, A 2020, ' TFEB regulates murine liver cell fate during development and regeneration ', Nature Communications, vol. 11, no. 1, 2461 . https://doi.org/10.1038/s41467-020-16300-x
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature communications, vol 11, iss 1
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature communications, vol 11, iss 1
Nature Communications
It is well established that pluripotent stem cells in fetal and postnatal liver (LPCs) can differentiate into both hepatocytes and cholangiocytes. However, the signaling pathways implicated in the differentiation of LPCs are still incompletely unders
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d5314b8c610c8b861361f1fbdf8cd1a
https://hdl.handle.net/20.500.11820/28ac7cb3-4fea-443e-8589-7951236bbe85
https://hdl.handle.net/20.500.11820/28ac7cb3-4fea-443e-8589-7951236bbe85
Autor:
Fabio Arturo Iannotti, Luca D’Orsi, Vincenzo Di Marzo, Elisabetta Gazzerro, Raffaele Capasso, Ester Pagano, Elvira De Leonibus, Filomena Grazia Alvino, Aniello Schiano Moriello, Luciano De Petrocellis, Nicolina Cristina Sorrentino
Publikováno v:
British Journal of Pharmacology. 176:1568-1584
Background and purpose Duchenne muscular dystrophy (DMD), caused by dystrophin deficiency, results in chronic inflammation and irreversible skeletal muscle degeneration. Moreover, the associated impairment of autophagy greatly contributes to the aggr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e6b1c82930d5428346bab5a229a8d380
https://doi.org/10.1111/bph.14460
https://doi.org/10.1111/bph.14460
Autor:
Giulio Piluso, Michele Iacomino, Ida Luisa Rotundo, Alberto Auricchio, Gerardo Nigro, Alessio Lancioni, Vincenzo Nigro, Marco Savarese, Luca D'Orsi
Publikováno v:
Human Gene Therapy; Vol 24
"Abstract The BIO14.6 hamster carries a mutation in the delta sarcoglycan gene causing muscular dystrophy and cardiomyopathy. The disease can be prevented by systemic delivery of delta sarcoglycan cDNA using adeno-associated viruses (AAVs). However,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a5049d29469c47e3f57f40028ed320b
Autor:
Jeffrey E. Pessin, Pradip K. Saha, Gelsomina Mansueto, Francesca Solagna, Haihong Zong, Andrea Ballabio, Ivano Di Meo, Andrea Armani, Massimo Zeviani, Luca D’Orsi, Vanina Romanello, Marco Sandri, Paolo Grumati, Costanza Lamperti, Rossella De Cegli, Caterina Tezze, Silvia Marchet, Bert Blaauw, Carlo Viscomi, Paolo Bonaldo, Elena V. Polishchuk
Publikováno v:
Cell Metabolism
Summary The transcription factor EB (TFEB) is an essential component of lysosomal biogenesis and autophagy for the adaptive response to food deprivation. To address the physiological function of TFEB in skeletal muscle, we have used muscle-specific g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09b5dabfe7e856484511ea9111da2cc8
Autor:
Giovanna L. Liguori, Antonio Barbieri, Annamaria Liguoro, Emilia Giorgio, Claudio Arra, Sara Mancinelli, Giuseppe Palma, Luca D'Orsi
Publikováno v:
International journal of oncology 45 (2014): 31–40. doi:10.3892/ijo.2014.2412
info:cnr-pdr/source/autori:Giorgio, Emilia; Liguoro, Annamaria; D'Orsi, Luca; Mancinelli, Sara; Barbieri, Antonio; Palma, Giuseppe; Arra, Claudio; Liguori, Giovanna L./titolo:Cripto haploinsufficiency affects in vivo colon tumor development/doi:10.3892%2Fijo.2014.2412/rivista:International journal of oncology/anno:2014/pagina_da:31/pagina_a:40/intervallo_pagine:31–40/volume:45
International Journal of Oncology
info:cnr-pdr/source/autori:Giorgio, Emilia; Liguoro, Annamaria; D'Orsi, Luca; Mancinelli, Sara; Barbieri, Antonio; Palma, Giuseppe; Arra, Claudio; Liguori, Giovanna L./titolo:Cripto haploinsufficiency affects in vivo colon tumor development/doi:10.3892%2Fijo.2014.2412/rivista:International journal of oncology/anno:2014/pagina_da:31/pagina_a:40/intervallo_pagine:31–40/volume:45
International Journal of Oncology
Colorectal cancer is one of the most common and aggressive cancers arising from alterations in various signaling pathways, such as the WNT, RAS-MAPK, PI3K and transforming growth factor-beta (TGF-beta) pathways. Cripto (also called Teratocarcinoma-de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df82c270b9bd38e793d5ffea2f5a4062
http://www.cnr.it/prodotto/i/316892
http://www.cnr.it/prodotto/i/316892
Autor:
Carmine Spampanato, Andrea Ballabio, Luca D’Orsi, Paola Saccone, Elvira De Leonibus, Irene Sambri, Ciro Monaco, Edoardo Nusco, Nicolina Cristina Sorrentino, Elena Polishchuk, Alessandro Fraldi
Publikováno v:
EMBO molecular medicine (Online) 5 (2013): 675–690. doi:10.1002/emmm.201202083
info:cnr-pdr/source/autori:Sorrentino N.C.; D'Orsi L.; Sambri I.; Nusco E.; Monaco C.; Spampanato C.; Polishchuk E.; Saccone P.; De Leonibus E.; Ballabio A.; Fraldi A./titolo:A highly secreted sulphamidase engineered to cross the blood-brain barrier corrects brain lesions of mice with mucopolysaccharidoses type IIIA/doi:10.1002%2Femmm.201202083/rivista:EMBO molecular medicine (Online)/anno:2013/pagina_da:675/pagina_a:690/intervallo_pagine:675–690/volume:5
EMBO Molecular Medicine
info:cnr-pdr/source/autori:Sorrentino N.C.; D'Orsi L.; Sambri I.; Nusco E.; Monaco C.; Spampanato C.; Polishchuk E.; Saccone P.; De Leonibus E.; Ballabio A.; Fraldi A./titolo:A highly secreted sulphamidase engineered to cross the blood-brain barrier corrects brain lesions of mice with mucopolysaccharidoses type IIIA/doi:10.1002%2Femmm.201202083/rivista:EMBO molecular medicine (Online)/anno:2013/pagina_da:675/pagina_a:690/intervallo_pagine:675–690/volume:5
EMBO Molecular Medicine
Mucopolysaccharidoses type IIIA (MPS-IIIA) is a neurodegenerative lysosomal storage disorder (LSD) caused by inherited defects of the sulphamidase gene. Here, we used a systemic gene transfer approach to demonstrate the therapeutic efficacy of a chim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03d4bd95807831866ee3db6a3160d40c
Autor:
Giulio Piluso, Alessio Lancioni, Kevin P. Campbell, Luca D'Orsi, Gerardo Nigro, Mafalda Cacciottolo, Ida Luisa Rotundo, S. Aurino, Yvonne M. Kobayashi, Dario Acampora, Vincenzo Nigro
Publikováno v:
Human Molecular Genetics; Vol 20
Human Molecular Genetics
Human Molecular Genetics
Cardiomyopathy is a puzzling complication in addition to skeletal muscle pathology for patients with mutations in β-, γ- or δ-sarcoglycan (SG) genes. Patients with mutations in α-SG rarely have associated cardiomyopathy, or their cardiac patholog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48a1d862722ba474ae537c019b64270a
http://hdl.handle.net/11591/190438
http://hdl.handle.net/11591/190438