Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Luca, Vecchia"'
Autor:
Kamel El Omari, Ramona Duman, Vitaliy Mykhaylyk, Christian M. Orr, Merlyn Latimer-Smith, Graeme Winter, Vinay Grama, Feng Qu, Kiran Bountra, Hok Sau Kwong, Maria Romano, Rosana I. Reis, Lutz Vogeley, Luca Vecchia, C. David Owen, Sina Wittmann, Max Renner, Miki Senda, Naohiro Matsugaki, Yoshiaki Kawano, Thomas A. Bowden, Isabel Moraes, Jonathan M. Grimes, Erika J. Mancini, Martin A. Walsh, Cristiane R. Guzzo, Raymond J. Owens, E. Yvonne Jones, David G. Brown, Dave I. Stuart, Konstantinos Beis, Armin Wagner
Publikováno v:
Communications Chemistry, Vol 6, Iss 1, Pp 1-11 (2023)
Abstract Despite recent advances in cryo-electron microscopy and artificial intelligence-based model predictions, a significant fraction of structure determinations by macromolecular crystallography still requires experimental phasing, usually by mea
Externí odkaz:
https://doaj.org/article/8684a241320c432f8b25757e0cf6d695
Autor:
Luca Vecchia, Francesco Di Gioia, Antonio Ferrante, Jason C. Hong, Charles White, Erin N. Rosskopf
Publikováno v:
Agronomy, Vol 10, Iss 10, p 1614 (2020)
The adoption of anaerobic soil disinfestation (ASD), a biologically-based method for the management of soilborne pests and pathogens at the commercial scale strictly depends on the availability of effective and low-cost sources of carbon (C). A three
Externí odkaz:
https://doaj.org/article/6c13bc754bfb4419b6850106bb4174e7
Autor:
Nicky Willis, William Mahy, James Sipthorp, Yuguang Zhao, Hannah Woodward, Benjamin Atkinson, Elliott Bayle, Fredrik Svensson, Sarah Frew, Fiona Jeganathan, Amy Monaghan, Stefano Benvegnu, Sarah Jolly, Luca Vecchia, Reinis Ruza, Svend Kjaer, Steven Howell, Ambrosius Snidjers, Magda Bictash, Patricia Salinas, Jean-Paul Vincent, Yvonne Jones, Paul Whiting, Paul Fish
Notum is a carboxylesterase that suppresses Wnt signaling through deacylation of an essential palmitoleate group on Wnt proteins. There is a growing understanding of the role Notum plays in human disease such as colorectal cancer and Alzheimer’s di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8addc522ec8ef944de3c1786ccffb9ca
https://doi.org/10.26434/chemrxiv-2022-f05w8
https://doi.org/10.26434/chemrxiv-2022-f05w8
Autor:
Yuguang Zhao, William Mahy, Nicky J. Willis, Hannah L. Woodward, David Steadman, Elliott D. Bayle, Benjamin N. Atkinson, James Sipthorp, Luca Vecchia, Reinis R. Ruza, Karl Harlos, Fiona Jeganathan, Stefan Constantinou, Artur Costa, Svend Kjær, Magda Bictash, Patricia C. Salinas, Paul Whiting, Jean-Paul Vincent, Paul V. Fish, E. Yvonne Jones
The Wnt signaling suppressor Notum is a promising target for osteoporosis, Alzheimer's disease, and colorectal cancers. To develop novel Notum inhibitors, we used an X-ray crystallographic fragment screen with the Diamond-SGC Poised Library (DSPL) an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f547dc38fab64d9f08bf48b45b75fa9e
Autor:
Nicky J. Willis, William Mahy, James Sipthorp, Yuguang Zhao, Hannah L. Woodward, Benjamin N. Atkinson, Elliott D. Bayle, Fredrik Svensson, Sarah Frew, Fiona Jeganathan, Amy Monaghan, Stefano Benvegnù, Sarah Jolly, Luca Vecchia, Reinis R. Ruza, Svend Kjær, Steven Howell, Ambrosius P. Snijders, Magda Bictash, Patricia C. Salinas, Jean-Paul Vincent, E. Yvonne Jones, Paul Whiting, Paul V. Fish
Notum is a carboxylesterase that suppresses Wnt signaling through deacylation of an essential palmitoleate group on Wnt proteins. There is a growing understanding of the role Notum plays in human diseases such as colorectal cancer and Alzheimer's dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3474b8ac04a0b606e41a67edadf62c69
Autor:
William, Mahy, Nicky J, Willis, Yuguang, Zhao, Hannah L, Woodward, Fredrik, Svensson, James, Sipthorp, Luca, Vecchia, Reinis R, Ruza, James, Hillier, Svend, Kjær, Sarah, Frew, Amy, Monaghan, Magda, Bictash, Patricia C, Salinas, Paul, Whiting, Jean-Paul, Vincent, E Yvonne, Jones, Paul V, Fish
Publikováno v:
Journal of medicinal chemistry. 63(21)
Carboxylesterase Notum is a negative regulator of the Wnt signaling pathway. There is an emerging understanding of the role Notum plays in disease, supporting the need to discover new small-molecule inhibitors. A crystallographic X-ray fragment scree
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::07128c1ea3b73521973fe7fd4ebe3825
https://pubmed.ncbi.nlm.nih.gov/33124429
https://pubmed.ncbi.nlm.nih.gov/33124429
Autor:
Benjamin N, Atkinson, David, Steadman, Yuguang, Zhao, James, Sipthorp, Luca, Vecchia, Reinis R, Ruza, Fiona, Jeganathan, Georgie, Lines, Sarah, Frew, Amy, Monaghan, Svend, Kjær, Magda, Bictash, E Yvonne, Jones, Paul V, Fish
Publikováno v:
MedChemComm
Optimization of fragment hit 3 identified isoquinoline 45 as a potent inhibitor of NOTUM with an unexpected flipped binding mode.
NOTUM is a carboxylesterase that has been shown to act by mediating the O-depalmitoleoylation of Wnt proteins resul
NOTUM is a carboxylesterase that has been shown to act by mediating the O-depalmitoleoylation of Wnt proteins resul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dbb625a59f2dade8bff75e1d10556061
https://pubmed.ncbi.nlm.nih.gov/31534655
https://pubmed.ncbi.nlm.nih.gov/31534655
Autor:
Antonio Ferrante, Charles White, Luca Vecchia, Erin N. Rosskopf, Francesco Di Gioia, Jason C. Hong
Publikováno v:
Agronomy, Vol 10, Iss 1614, p 1614 (2020)
Agronomy
Volume 10
Issue 10
Agronomy
Volume 10
Issue 10
The adoption of anaerobic soil disinfestation (ASD), a biologically-based method for the management of soilborne pests and pathogens at the commercial scale strictly depends on the availability of effective and low-cost sources of carbon (C). A three
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94e873131674af0f4f4f16750543c339
https://doi.org/10.3390/agronomy10101614
https://doi.org/10.3390/agronomy10101614
Publikováno v:
Mini-Reviews in Medicinal Chemistry. 13:1398-1406
Anti-angiogenic therapy represents a very promising approach in cancer treatment, as most tumors needs to be supplied by a functional vascular network in order to grow beyond the local boundaries and metastatize. The accessibility of vessels to drug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::50226e450b312357fa7f35ef59e81745
https://doi.org/10.2174/13895575113139990065
https://doi.org/10.2174/13895575113139990065
Publikováno v:
Journal of Immunotherapy. 34:611-628
Antibody-drug conjugates (also known as "immunoconjugates") have only recently entered the arsenal of anticancer drugs, but the number of undergoing clinical trials including them is ever increasing and most therapeutic antibodies are now patented in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6704c8efea868fef7bd5df4aefe9394a
https://doi.org/10.1097/cji.0b013e318234ecf5
https://doi.org/10.1097/cji.0b013e318234ecf5