Zobrazeno 1 - 10
of 152
pro vyhledávání: '"Luca, Roz"'
Autor:
Susana Torres‐Martínez, Silvia Calabuig‐Fariñas, Andrea Moreno‐Manuel, Giulia Bertolini, Alejandro Herreros‐Pomares, Eva Escorihuela, Elena Duréndez‐Saéz, Ricardo Guijarro, Ana Blasco, Luca Roz, Carlos Camps, Eloisa Jantus‐Lewintre
Publikováno v:
Molecular Oncology, Vol 18, Iss 1, Pp 190-215 (2024)
Despite the success of therapies in lung cancer, more studies of new biomarkers for patient selection are urgently needed. The present study aims to analyze the role of galectin‐3 (GAL‐3) in the lung tumor microenvironment (TME) using tumorsphere
Externí odkaz:
https://doaj.org/article/e94f49441c4e4aeda21fd85df71bca0e
Autor:
Ilaria Petraroia, Patrizia Ghidotti, Giulia Bertolini, Francesca Pontis, Luca Roz, Melissa Balsamo, Paola Suatoni, Ugo Pastorino, Anna Maria Ferretti, Gabriella Sozzi, Orazio Fortunato
Publikováno v:
Cell Death and Disease, Vol 14, Iss 10, Pp 1-12 (2023)
Abstract Chronic obstructive pulmonary disease (COPD) is a risk factor for lung cancer development. COPD induces activation of hypoxia-induced signaling, causing remodeling of surrounding microenvironmental cells also modulating the release and cargo
Externí odkaz:
https://doaj.org/article/027a0899ef564e3680a7749293ab561f
Autor:
Ugo Pastorino, Massimo Milione, Paola Orecchia, Massimo Moro, Gabriella Sozzi, Monica Parodi, Giovanni Centonze, Fabio Murianni, Francesca Andriani, Ilaria Roato, Cecilia Gardelli, Melissa Balsamo, Giulia Taiè, Andrea Petretto, Chiara Lavarello , Luca Roz, Massimo Vitale, Giulia Bertolini
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 3 (2024)
Background Epithelial to mesenchymal transition (EMT) endows cancer cells with pro-metastatic properties, which appear most effective when cells enter an intermediate hybrid (H) state, characterized by integrated mesenchymal (M) and epithelial (E) tr
Externí odkaz:
https://doaj.org/article/f72425c485344776a7a4043b68dafea4
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Lung cancer is the deadliest cancer in the world, with the majority of patients presenting with advanced or metastatic disease at first diagnosis. The lungs are also one of the most common sites of metastasis from lung cancer and other tumors. Unders
Externí odkaz:
https://doaj.org/article/b201c0a487c2442ba0b6c1418255536e
Autor:
Francesca Pontis, Luca Roz, Mavis Mensah, Miriam Segale, Massimo Moro, Giulia Bertolini, Ilaria Petraroia, Giovanni Centonze, Anna Maria Ferretti, Paola Suatoni, Ugo Pastorino, Orazio Fortunato, Gabriella Sozzi
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-16 (2021)
Abstract Background Extracellular vesicles (EVs) containing specific subsets of functional biomolecules are released by all cell types and analysis of circulating EVs can provide diagnostic and prognostic information. To date, little is known regardi
Externí odkaz:
https://doaj.org/article/a792b7d6bbef42c7bf9dcc4f2816b639
Autor:
Orazio Fortunato, Dimas Carolina Belisario, Mara Compagno, Francesca Giovinazzo, Cristiano Bracci, Ugo Pastorino, Alberto Horenstein, Fabio Malavasi, Riccardo Ferracini, Stefania Scala, Gabriella Sozzi, Luca Roz, Ilaria Roato, Giulia Bertolini
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Cancer stem cells (CSCs) are functionally defined as the cell subset with greater potential to initiate and propagate tumors. Within the heterogeneous population of lung CSCs, we previously identified highly disseminating CD133+CXCR4+ cells able to i
Externí odkaz:
https://doaj.org/article/7f22199dd81f4a9aacee719fd3869c9f
Autor:
Francesca Andriani, Elena Landoni, Mavis Mensah, Federica Facchinetti, Rosalba Miceli, Elda Tagliabue, Marta Giussani, Maurizio Callari, Loris De Cecco, Mario Paolo Colombo, Luca Roz, Ugo Pastorino, Gabriella Sozzi
Publikováno v:
BMC Cancer, Vol 18, Iss 1, Pp 1-14 (2018)
Abstract Background Interactions between cancer cells and the surrounding microenvironment are crucial determinants of cancer progression. During this process, bi-directional communication among tumor cells and cancer associated fibroblasts (CAF) reg
Externí odkaz:
https://doaj.org/article/aa34c5b969ec4451a63b5f428a35894e
Autor:
Julie George, Vonn Walter, Martin Peifer, Ludmil B. Alexandrov, Danila Seidel, Frauke Leenders, Lukas Maas, Christian Müller, Ilona Dahmen, Tiffany M. Delhomme, Maude Ardin, Noemie Leblay, Graham Byrnes, Ruping Sun, Aurélien De Reynies, Anne McLeer-Florin, Graziella Bosco, Florian Malchers, Roopika Menon, Janine Altmüller, Christian Becker, Peter Nürnberg, Viktor Achter, Ulrich Lang, Peter M. Schneider, Magdalena Bogus, Matthew G. Soloway, Matthew D. Wilkerson, Yupeng Cun, James D. McKay, Denis Moro-Sibilot, Christian G. Brambilla, Sylvie Lantuejoul, Nicolas Lemaitre, Alex Soltermann, Walter Weder, Verena Tischler, Odd Terje Brustugun, Marius Lund-Iversen, Åslaug Helland, Steinar Solberg, Sascha Ansén, Gavin Wright, Benjamin Solomon, Luca Roz, Ugo Pastorino, Iver Petersen, Joachim H. Clement, Jörg Sänger, Jürgen Wolf, Martin Vingron, Thomas Zander, Sven Perner, William D. Travis, Stefan A. Haas, Magali Olivier, Matthieu Foll, Reinhard Büttner, David Neil Hayes, Elisabeth Brambilla, Lynnette Fernandez-Cuesta, Roman K. Thomas
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
The molecular nature of large-cell neuroendocrine lung carcinomas (LCNEC) has remained unclear. Here, the authors show LCNECs represent a distinct transcriptional subgroup among lung cancers and comprise two molecular subgroups, type I (TP53 and STK1
Externí odkaz:
https://doaj.org/article/0b984304ba014836a34f2b6d1a57b335
Autor:
Francesca Andriani, Maria Teresa Majorini, Miguel Mano, Elena Landoni, Rosalba Miceli, Federica Facchinetti, Mavis Mensah, Enrico Fontanella, Matteo Dugo, Mauro Giacca, Ugo Pastorino, Gabriella Sozzi, Domenico Delia, Luca Roz, Daniele Lecis
Publikováno v:
Journal of Hematology & Oncology, Vol 11, Iss 1, Pp 1-17 (2018)
Abstract Background Fibroblasts are crucial mediators of tumor-stroma cross-talk through synthesis and remodeling of the extracellular matrix and production of multiple soluble factors. Nonetheless, little is still known about specific determinants o
Externí odkaz:
https://doaj.org/article/129bb9357c5543c1a5ce2d32753e0fd9
Autor:
Massimo Moro, Giulia Bertolini, Roberto Caserini, Cristina Borzi, Mattia Boeri, Alessandra Fabbri, Giorgia Leone, Patrizia Gasparini, Carlotta Galeone, Giuseppe Pelosi, Luca Roz, Gabriella Sozzi, Ugo Pastorino
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract Despite many years of research efforts, lung cancer still remains the leading cause of cancer deaths worldwide. Objective of this study was to set up a platform of non-small cell lung cancer patient derived xenografts (PDXs) faithfully repre
Externí odkaz:
https://doaj.org/article/a5c3a54063d1498f9a6a7e52bb320e62