Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Luca, Piali"'
Autor:
Barbara Klughammer, Luca Piali, Alexandra Nica, Sandra Nagel, Lorna Bailey, Christoph Jochum, Stanislav Ignatenko, Angela Bläuer, Sabrina Danilin, Pratiksha Gulati, Joanne Hayward, Petar Scepanovic, Jitao David Zhang, Satish Bhosale, Chui Fung Chong, Andreas Christ
Publikováno v:
Clinical and Translational Medicine, Vol 13, Iss 11, Pp n/a-n/a (2023)
Abstract Background The NLRP3 inflammasome drives release of pro‐inflammatory cytokines including interleukin (IL)‐1β and IL‐18 and is a potential target for ulcerative colitis (UC). Selnoflast (RO7486967) is an orally active, potent, selectiv
Externí odkaz:
https://doaj.org/article/b80fc258a15c4af3b3c8fab7ec3257fd
Autor:
Dominik Hartl, Valeria de Luca, Anna Kostikova, Jason Laramie, Scott Kennedy, Enrico Ferrero, Richard Siegel, Martin Fink, Sohail Ahmed, John Millholland, Alexander Schuhmacher, Markus Hinder, Luca Piali, Adrian Roth
Publikováno v:
Journal of Translational Medicine, Vol 19, Iss 1, Pp 1-14 (2021)
Abstract In the era of precision medicine, digital technologies and artificial intelligence, drug discovery and development face unprecedented opportunities for product and business model innovation, fundamentally changing the traditional approach of
Externí odkaz:
https://doaj.org/article/be644fa7db0840c4a7d56dccea721ede
Publikováno v:
Journal of Medicinal Chemistry. 65:11533-11549
The chemokine receptor CXCR3 allows the selective recruitment of innate and adaptive inflammatory immune cells into inflamed tissue. CXCR3 ligands are secreted after exposure to pro-inflammatory cytokines. Upon binding to CXCR3 ligands, CXCR3 express
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c90f09542dd97c80892db80d69bfcf7b
https://doi.org/10.1021/acs.jmedchem.2c00676
https://doi.org/10.1021/acs.jmedchem.2c00676
Publikováno v:
Journal of Medicinal Chemistry. 65:11513-11532
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::41fc55d964ee971478ede9a5e0c6b845
https://doi.org/10.1021/acs.jmedchem.2c00675
https://doi.org/10.1021/acs.jmedchem.2c00675
Autor:
Emmanuel A, Meyer, Päivi, Äänismaa, Sylvie, Froidevaux, Marcel, Keller, Luca, Piali, Eva, Caroff
Publikováno v:
Journal of medicinal chemistry. 65(17)
The chemokine receptor CXCR3 is a seven-transmembrane G-protein-coupled receptor (GPCR) involved in various pathologies, in particular autoimmune diseases. It is activated by the three chemokine ligands CXCL9, CXCL10, and CXCL11 and enables the recru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6d83fda98a6de4d714585d8f1db0f4c4
https://pubmed.ncbi.nlm.nih.gov/35947786
https://pubmed.ncbi.nlm.nih.gov/35947786
Autor:
Sylvaine You, Luca Piali, Chantal Kuhn, Beat Steiner, Virginia Sauvaget, Fabrice Valette, Martine Clozel, Jean-François Bach, Lucienne Chatenoud
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e77296 (2013)
In the present study, we investigated the therapeutic potential of a selective S1P1 receptor modulator, ponesimod, to protect and reverse autoimmune diabetes in non-obese diabetic (NOD) mice. Ponesimod was administered orally to NOD mice starting at
Externí odkaz:
https://doaj.org/article/2b57a22245a041fd9669302f5d94f32c
Autor:
Marlene Ballbach, Darina M. Siegmund, Luca Piali, Angelika Dannert, Rupert Handgretinger, Nikolaus Rieber, Dominik Hartl, Anurag Singh
Publikováno v:
Immunology Letters. 192:1-6
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous cell population expanded in cancer, infection and autoimmunity capable of suppressing T-cell functions. Checkpoint inhibitors have emerged as a key therapeutic strategy in immune-oncology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba768fb2f0cbf758c4007ade2893121b
https://doi.org/10.1016/j.imlet.2017.10.001
https://doi.org/10.1016/j.imlet.2017.10.001
Autor:
Laetitia, Pouzol, Luca, Piali, Claude Ca, Bernard, Marianne M, Martinic, Beat, Steiner, Martine, Clozel
Publikováno v:
Innovations in clinical neuroscience. 16(3-4)
Background: Despite the recent approval of new oral therapies for the treatment of multiple sclerosis (MS), a significant percentage of patients are still not free from disease activity. In view of the complex pathogenesis and the relapsing and progr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a9e0e78968cb956143fca25c3fe3b3ce
https://pubmed.ncbi.nlm.nih.gov/31214480
https://pubmed.ncbi.nlm.nih.gov/31214480
Autor:
David A. Schubert, Sebastian Fuchs, Nicolas Staedler, Andreas P. Frei, Nadia Sawas, Annalisa D’Andrea, Luca Piali, Robert Zeiser, Petr Hruz
Publikováno v:
European journal of immunology. 49(3)
Immune checkpoints are regulators of immune cells and play key roles in the modulation of immune responses. The role of checkpoints in autoimmune disease is poorly understood but likely to be central since checkpoint inhibition during cancer treatmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b5c37704ec38cf52a527c9f0c806850
https://pubmed.ncbi.nlm.nih.gov/30578679
https://pubmed.ncbi.nlm.nih.gov/30578679
Autor:
Luca, Piali, Magdalena, Birker-Robaczewska, Cyrille, Lescop, Sylvie, Froidevaux, Nicole, Schmitz, Keith, Morrison, Christopher, Kohl, Markus, Rey, Rolf, Studer, Enrico, Vezzali, Patrick, Hess, Martine, Clozel, Beat, Steiner, Martin H, Bolli, Oliver, Nayler
Publikováno v:
Pharmacology Research & Perspectives
Sphingosine‐1‐phosphate receptor 1 (S1P1) modulators sequester circulating lymphocytes within lymph nodes, thereby preventing potentially pathogenic autoimmune cells from exiting into the blood stream and reaching inflamed tissues. S1P1 receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0454bce66af04dd6f9e57d2364b830fd
https://pubmed.ncbi.nlm.nih.gov/29226621
https://pubmed.ncbi.nlm.nih.gov/29226621