Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Luca, Parca"'
Autor:
Salvatore Daniele Bianco, Luca Parca, Francesco Petrizzelli, Tommaso Biagini, Agnese Giovannetti, Niccolò Liorni, Alessandro Napoli, Massimo Carella, Vincent Procaccio, Marie T. Lott, Shiping Zhang, Angelo Luigi Vescovi, Douglas C. Wallace, Viviana Caputo, Tommaso Mazza
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Mitochondrial dysfunction has pleiotropic effects and is frequently caused by mitochondrial DNA mutations. However, factors such as significant variability in clinical manifestations make interpreting the pathogenicity of variants in the mit
Externí odkaz:
https://doaj.org/article/64f1c2068b1f4c58ae29cd7b9a674f0e
Publikováno v:
Non-coding RNA Research, Vol 7, Iss 2, Pp 98-105 (2022)
Recent research provides insight into the ability of miRNA to regulate various pathways in several cancer types. Despite their involvement in the regulation of the mRNA via targeting the 3′UTR, there are relatively few studies examining the changes
Externí odkaz:
https://doaj.org/article/842a462ecb0141479b0b78d3f3a86ad8
Autor:
Simone Di Sanzo, Katrin Spengler, Anja Leheis, Joanna M. Kirkpatrick, Theresa L. Rändler, Tim Baldensperger, Therese Dau, Christian Henning, Luca Parca, Christian Marx, Zhao-Qi Wang, Marcus A. Glomb, Alessandro Ori, Regine Heller
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-22 (2021)
Accumulation of advanced glycation end products such as carboxymethyllysine (CML) has been associated with aging but their molecular roles are largely unclear. Here, the authors use proteomics to identify CML sites and show that CML formation affects
Externí odkaz:
https://doaj.org/article/2a95d56d607f461daa73332371e24e27
Autor:
Francesco Petrizzelli, Tommaso Biagini, Alessandro Barbieri, Luca Parca, Noemi Panzironi, Stefano Castellana, Viviana Caputo, Angelo Luigi Vescovi, Massimo Carella, Tommaso Mazza
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 18, Iss , Pp 2033-2042 (2020)
Mutations in genes encoding for histone methylation proteins are associated with several developmental disorders. Among them, KDM6A is the disease causative gene of type 2 Kabuki Syndrome, a rare multisystem disease. While nonsense mutations and shor
Externí odkaz:
https://doaj.org/article/5f371d571e554adabd228f2298c8b58a
Publikováno v:
Molecular Systems Biology, Vol 14, Iss 7, Pp 1-9 (2018)
Abstract Quantitative mass spectrometry enables to monitor the abundance of thousands of proteins across biological conditions. Currently, most data analysis approaches rely on the assumption that the majority of the observed proteins remain unchange
Externí odkaz:
https://doaj.org/article/76cd8ccd42c34bef92e0e55190ef9bf2
Autor:
Sebastiano Giallongo, Oriana Lo Re, Gabriela Lochmanová, Luca Parca, Francesco Petrizzelli, Zbyněk Zdráhal, Tommaso Mazza, Manlio Vinciguerra
Publikováno v:
Biology, Vol 10, Iss 7, p 659 (2021)
Background: Gene expression in eukaryotic cells can be governed by histone variants, which replace replication-coupled histones, conferring unique chromatin properties. MacroH2A1 is a histone H2A variant containing a domain highly similar to H2A and
Externí odkaz:
https://doaj.org/article/230ed6c9d17645f5b903e3e7a7758598
Autor:
Lucia Natarelli, Luca Parca, Tommaso Mazza, Christian Weber, Fabio Virgili, Deborah Fratantonio
Publikováno v:
Non-Coding RNA, Vol 7, Iss 1, p 14 (2021)
The respiratory system is one of the most affected targets of SARS-CoV-2. Various therapies have been utilized to counter viral-induced inflammatory complications, with diverse success rates. Pending the distribution of an effective vaccine to the wh
Externí odkaz:
https://doaj.org/article/3e431c349f3b48bf930876698d17e13d
Autor:
Marcus A. Glomb, Christian Marx, Simone Di Sanzo, Anja Leheis, Christian Henning, Katrin Spengler, Zhao-Qi Wang, Alessandro Ori, Regine Heller, Luca Parca, Tim Baldensperger, Therese Dau, Theresa L Rändler, Joanna Kirkpatrick
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-22 (2021)
Nature Communications
Nature Communications
Posttranslational mechanisms play a key role in modifying the abundance and function of cellular proteins. Among these, modification by advanced glycation end products has been shown to accumulate during aging and age-associated diseases but specific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdea2d3ca4988628aa7399f4cfe15410
https://doaj.org/article/2a95d56d607f461daa73332371e24e27
https://doaj.org/article/2a95d56d607f461daa73332371e24e27
Autor:
Matthew J Betts, Oliver Wichmann, Mathias Utz, Timon Andre, Evangelia Petsalaki, Pablo Minguez, Luca Parca, Frederick P Roth, Anne-Claude Gavin, Peer Bork, Robert B Russell
Publikováno v:
PLoS Computational Biology, Vol 13, Iss 3, p e1005462 (2017)
Proteomics techniques can identify thousands of phosphorylation sites in a single experiment, the majority of which are new and lack precise information about function or molecular mechanism. Here we present a fast method to predict potential phospho
Externí odkaz:
https://doaj.org/article/b521f5ae76f94fd4b5eb0656925972b3
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2449
The prediction of the cancer cell lines sensitivity to a specific treatment is one of the current challenges in precision medicine. With omics and pharmacogenomics data being available for over 1000 cancer cell lines, several machine learning and dee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c16bd2c249ae959fec25490afecd93cf
https://pubmed.ncbi.nlm.nih.gov/35507263
https://pubmed.ncbi.nlm.nih.gov/35507263