Zobrazeno 1 - 10
of 83
pro vyhledávání: '"Luca, Jovine"'
Publikováno v:
eLife, Vol 13 (2024)
A crucial event in sexual reproduction is when haploid sperm and egg fuse to form a new diploid organism at fertilization. In mammals, direct interaction between egg JUNO and sperm IZUMO1 mediates gamete membrane adhesion, yet their role in fusion re
Externí odkaz:
https://doaj.org/article/13a1e1b1357d4508b67637d384f38c9c
Autor:
Krista R. B. Gert, Karin Panser, Joachim Surm, Benjamin S. Steinmetz, Alexander Schleiffer, Luca Jovine, Yehu Moran, Fyodor Kondrashov, Andrea Pauli
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Molecular compatibility between gametes is a prerequisite for successful fertilization. As long as a sperm and egg can recognize and bind each other via their surface proteins, gamete fusion may occur even between members of separate species
Externí odkaz:
https://doaj.org/article/145bb6c80580420988cfedaedfd84a84
Autor:
Eva Furrow, Luca Rampoldi, Luca Jovine, Jeffrey A. Wesson, Amy E. Treeful, Muthuvel Jayachandran, John C. Lieske, Michael F. Romero, Jody P. Lulich
Publikováno v:
Journal of Clinical and Translational Science, Vol 8, Pp 129-129 (2024)
OBJECTIVES/GOALS: Using a natural canine model of kidney stone disease, we previously identified a pathogenic variant in the uromodulin gene (UMOD) that imparts a dramatic risk for calcium oxalate (CaOx) stones. This study was designed to characteriz
Externí odkaz:
https://doaj.org/article/d4159f2b467b4b5ebdebdd2fe9fe2d49
Autor:
David Moi, Shunsuke Nishio, Xiaohui Li, Clari Valansi, Mauricio Langleib, Nicolas G. Brukman, Kateryna Flyak, Christophe Dessimoz, Daniele de Sanctis, Kathryn Tunyasuvunakool, John Jumper, Martin Graña, Héctor Romero, Pablo S. Aguilar, Luca Jovine, Benjamin Podbilewicz
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Sexual reproduction in eukaryotes involves gamete fusion, mediated by fusogenic proteins. Here, the authors identify fusogenic protein homologs encoded within mobile genetic elements in archaeal genomes, solve the crystal structure of one of the prot
Externí odkaz:
https://doaj.org/article/e91bd8b053f6444b80b6f8d4bed3bed4
Autor:
Eriklis Nogueira, Filip Tirpák, Lauren E. Hamilton, Michal Zigo, Karl Kerns, Miriam Sutovsky, JaeWoo Kim, Dietrich Volkmann, Luca Jovine, Jeremy F. Taylor, Robert D. Schnabel, Peter Sutovsky
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
This study is part of a concerted effort to identify and phenotype rare, deleterious mutations that adversely affect sperm quality, or convey high developmental and fertility potential to embryos and ensuing progeny. A rare, homozygous mutation in EM
Externí odkaz:
https://doaj.org/article/fc990fac3292487aa7065b91da7cb39c
Autor:
Céline Schaeffer, Claudia Izzi, Andrea Vettori, Elena Pasqualetto, Davide Cittaro, Dejan Lazarevic, Gianluca Caridi, Barbara Gnutti, Cinzia Mazza, Luca Jovine, Francesco Scolari, Luca Rampoldi
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Abstract Autosomal dominant tubulointerstitial kidney disease (ADTKD) is a genetically heterogeneous renal disorder leading to progressive loss of renal function. ADTKD-REN is due to rare mutations in renin, all localized in the protein leader peptid
Externí odkaz:
https://doaj.org/article/8dc16d1b7739477cbf9a5b1523e9ce60
Autor:
Kaoru Nishimura, Elisa Dioguardi, Shunsuke Nishio, Alessandra Villa, Ling Han, Tsukasa Matsuda, Luca Jovine
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Glycoprotein ZP1 is a component of the oocyte’s zona pellucida (ZP), and mutations in human ZP1 are linked to female infertility. Here, using structure-function analysis, the authors suggest that filament cross-linking by ZP1 is required to form a
Externí odkaz:
https://doaj.org/article/56d66a23508b4bf9b30688e79a38ded7
Autor:
Anna Cuppari, Hagen Körschgen, Dirk Fahrenkamp, Carlo Schmitz, Tibisay Guevara, Konstantin Karmilin, Michael Kuske, Mario Olf, Eileen Dietzel, Irene Yiallouros, Daniele de Sanctis, Theodoros Goulas, Ralf Weiskirchen, Willi Jahnen-Dechent, Julia Floehr, Walter Stoecker, Luca Jovine, F. Xavier Gomis-Rüth
Publikováno v:
IUCrJ, Vol 6, Iss 2, Pp 317-330 (2019)
Mammalian fetuin-A and fetuin-B are abundant serum proteins with pleiotropic functions. Fetuin-B is a highly selective and potent inhibitor of metallopeptidases (MPs) of the astacin family, which includes ovastacin in mammals. By inhibiting ovastacin
Externí odkaz:
https://doaj.org/article/24d7abbd57094fd4a8c4d4c291760b72
Autor:
Melanie Balbach, Hussein Hamzeh, Jan F. Jikeli, Christoph Brenker, Christian Schiffer, Jan N. Hansen, Pia Neugebauer, Christian Trötschel, Luca Jovine, Ling Han, Harvey M. Florman, U. Benjamin Kaupp, Timo Strünker, Dagmar Wachten
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Mammalian oocytes are enveloped by the zona pellucida (ZP), an extracellular matrix of glycoproteins. In sperm, stimulation with ZP proteins evokes a rapid Ca2+ influx via the sperm-specific, pH-sensitive Ca2+ channel CatSper. However, the physiologi
Externí odkaz:
https://doaj.org/article/87d6e04ca4ce4b2cb1e990ab3f22a423
Autor:
Takako Saito, Marcel Bokhove, Romina Croci, Sara Zamora-Caballero, Ling Han, Michelle Letarte, Daniele de Sanctis, Luca Jovine
Publikováno v:
Cell Reports, Vol 19, Iss 9, Pp 1917-1928 (2017)
Endoglin (ENG)/CD105 is an essential endothelial cell co-receptor of the transforming growth factor β (TGF-β) superfamily, mutated in hereditary hemorrhagic telangiectasia type 1 (HHT1) and involved in tumor angiogenesis and preeclampsia. Here, we
Externí odkaz:
https://doaj.org/article/614cca4ba20d460fbd9a84ab88c6aeb9