Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Luca, Gasparoli"'
Autor:
Luca Gasparoli, Clemence Virely, Alexia Tsakaneli, Noelia Che, Darren Edwards, Jack Bartram, Michael Hubank, Deepali Pal, Olaf Heidenreich, Joost H.A. Martens, Jasper de Boer, Owen Williams
Publikováno v:
Haematologica, Vol 109, Iss 4 (2023)
Advances in the clinical management of pediatric B-cell acute lymphoblastic leukemia (B-ALL) have dramatically improved outcomes for this disease. However, relapsed and high-risk disease still contribute to significant numbers of treatment failures.
Externí odkaz:
https://doaj.org/article/aa3599b620044cacb18115d1719e17ca
Autor:
Sandra Cantilena, Luca Gasparoli, Deepali Pal, Olaf Heidenreich, Jan‐Henning Klusmann, Joost H. A. Martens, Alexandre Faille, Alan J. Warren, Mawar Karsa, Ruby Pandher, Klaartje Somers, Owen Williams, Jasper de Boer
Publikováno v:
Clinical and Translational Medicine, Vol 12, Iss 6, Pp n/a-n/a (2022)
Abstract Background Improving the poor prognosis of infant leukaemias remains an unmet clinical need. This disease is a prototypical fusion oncoprotein‐driven paediatric cancer, with MLL (KMT2A)‐fusions present in most cases. Direct targeting of
Externí odkaz:
https://doaj.org/article/1c1567bc09014df8bcc740417102afeb
ARHGEF4 Regulates an Essential Oncogenic Program in t(12;21)-Associated Acute Lymphoblastic Leukemia
Autor:
Clemence Virely, Luca Gasparoli, Maurizio Mangolini, Katherine Clesham, Sarah Inglott, Darren Edwards, Stuart Adams, Jack Bartram, Sujith Samarasinghe, Philip Ancliff, Ajay Vora, Jasper de Boer, Owen Williams
Publikováno v:
HemaSphere, Vol 4, Iss 5, p e467 (2020)
Externí odkaz:
https://doaj.org/article/ba127412a40e48b59ab4563b710bbd5e
Autor:
Katherine Clesham, Vanessa Walf-Vorderwülbecke, Luca Gasparoli, Clemence Virely, Sandra Cantilena, Alexia Tsakaneli, Sarah Inglott, Stuart Adams, Sujith Samarasinghe, Jack Bartram, Gareth Williams, Jasper de Boer, Owen Williams
Publikováno v:
Leukemia. 36:1541-1549
A significant proportion of patients suffering from acute myeloid leukemia (AML) cannot be cured by conventional chemotherapy, relapsed disease being a common problem. Molecular targeting of essential oncogenic mediators is an attractive approach to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::094ce47f050048f64273465730cff700
https://doi.org/10.1038/s41375-022-01554-9
https://doi.org/10.1038/s41375-022-01554-9
ARHGEF4 Regulates an Essential Oncogenic Program in t(12;21)-Associated Acute Lymphoblastic Leukemia
Autor:
Maurizio Mangolini, Philip Ancliff, Owen Williams, Sarah Inglott, Ajay Vora, Luca Gasparoli, Clemence Virely, Katherine Clesham, Stuart Adams, Jack Bartram, Sujith Samarasinghe, Darren J. Edwards, Jasper de Boer
Publikováno v:
HemaSphere, Vol 4, Iss 5, p e467 (2020)
HemaSphere
HemaSphere
Supplemental Digital Content is available in the text
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6909ec77e96afab8f628d174e209fbc8
https://pubmed.ncbi.nlm.nih.gov/32984770
https://pubmed.ncbi.nlm.nih.gov/32984770
Autor:
Paul J. Lehner, Owen Williams, Michael Leitges, Hilde Schjerven, Maike Buchner, Luca Gasparoli, Marc Schmidt-Supprian, Eugene Park, Antonella Santoro, Stephan Stilgenbauer, Maurizio Mangolini, Johannes Bloehdorn, Joseph R. Boyd, Alexander Egle, Seth Frietze, James C Williamson, Ingo Ringshausen, Andrew M. Moore, Veronika Ecker, Jingyu Chen
Publikováno v:
Sci Transl Med
Overcoming drug resistance remains a key challenge to cure patients with acute and chronic B cell malignancies. Here, we describe a stromal cell–autonomous signaling pathway, which contributes to drug resistance of malignant B cells. We show that p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0edb52cd4d48e21a4f29e59a694e728
https://www.repository.cam.ac.uk/handle/1810/300977
https://www.repository.cam.ac.uk/handle/1810/300977
Publikováno v:
Klinische Pädiatrie.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc6b130c4418002ae30ec370864a31b3
https://doi.org/10.1055/s-0039-1687158
https://doi.org/10.1055/s-0039-1687158
Autor:
Massimo D'Amico, Luca Gasparoli, Mirko Severi, Tiziano Marzo, Giulia Petroni, Olivia Crociani, Gianluca Bartoli, Luigi Messori, Angela Guerriero, Heike Wulff, Serena Pillozzi, Annarosa Arcangeli, Andrea Becchetti, K. George Chandy, Roberto Udisti
Publikováno v:
British journal of cancer, vol 118, iss 2
Background: Platinum-based drugs such as Cisplatin are commonly employed for cancer treatment. Despite an initial therapeutic response, Cisplatin treatment often results in the development of chemoresistance. To identify novel approaches to overcome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f84dc1a34339521b4b6cad52245ed9e
http://hdl.handle.net/10281/181237
http://hdl.handle.net/10281/181237
Autor:
Serena, Pillozzi, Massimo, D'Amico, Gianluca, Bartoli, Luca, Gasparoli, Giulia, Petroni, Olivia, Crociani, Tiziano, Marzo, Angela, Guerriero, Luigi, Messori, Mirko, Severi, Roberto, Udisti, Heike, Wulff, K George, Chandy, Andrea, Becchetti, Annarosa, Arcangeli
Publikováno v:
British Journal of Cancer
Background: Platinum-based drugs such as Cisplatin are commonly employed for cancer treatment. Despite an initial therapeutic response, Cisplatin treatment often results in the development of chemoresistance. To identify novel approaches to overcome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0b43e97cbff20fe76ec5dccbe33e8b93
https://pubmed.ncbi.nlm.nih.gov/29161243
https://pubmed.ncbi.nlm.nih.gov/29161243
Autor:
P Ancliff, Maurizio Mangolini, Jack Bartram, Luca Gasparoli, J de Boer, Nick Goulden, Owen Williams, C Virely, Darren J. Edwards
Publikováno v:
Klinische Pädiatrie.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e04b6aaca36ae8ad2ed3978b1386c7b0
https://doi.org/10.1055/s-0037-1602187
https://doi.org/10.1055/s-0037-1602187