Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Luc Ver Donck"'
Autor:
Jonathan Janssens, Bart Hermans, Marc Vandermeeren, Erio Barale-Thomas, Marianne Borgers, Roland Willems, Greet Meulders, Cindy Wintmolders, Dries Van den Bulck, Astrid Bottelbergs, Luc Ver Donck, Peter Larsen, Dieder Moechars, Wilson Edwards, Marc Mercken, Bianca Van Broeck
Publikováno v:
Neurobiology of Disease, Vol 154, Iss , Pp 105365- (2021)
The imbalance between production and clearance of amyloid β (Aβ) peptides and their resulting accumulation in the brain is an early and crucial step in the pathogenesis of Alzheimer's disease (AD). Therefore, Aβ is strongly positioned as a promisi
Externí odkaz:
https://doaj.org/article/7f712f2755314a818f17894b585c61e7
Autor:
Eve Peeraer, Astrid Bottelbergs, Kristof Van Kolen, Ilie-Cosmin Stancu, Bruno Vasconcelos, Michel Mahieu, Hilde Duytschaever, Luc Ver Donck, An Torremans, Ellen Sluydts, Nathalie Van Acker, John A. Kemp, Marc Mercken, Kurt R. Brunden, John Q. Trojanowski, Ilse Dewachter, Virginia M.Y. Lee, Diederik Moechars
Publikováno v:
Neurobiology of Disease, Vol 73, Iss , Pp 83-95 (2015)
Neurofibrillary tangles composed of hyperphosphorylated fibrillized tau are found in numerous tauopathies including Alzheimer's disease. Increasing evidence suggests that tau pathology can be transmitted from cell-to-cell; however the mechanisms invo
Externí odkaz:
https://doaj.org/article/b7aec78036334916b239edf43aa5f797
Autor:
Steven Biesmans, Theo F. Meert, Jan A. Bouwknecht, Paul D. Acton, Nima Davoodi, Patrick De Haes, Jacobine Kuijlaars, Xavier Langlois, Liam J. R. Matthews, Luc Ver Donck, Niels Hellings, Rony Nuydens
Publikováno v:
Mediators of Inflammation, Vol 2013 (2013)
Substantial evidence indicates an association between clinical depression and altered immune function. Systemic administration of bacterial lipopolysaccharide (LPS) is commonly used to study inflammation-associated behavioral changes in rodents. In t
Externí odkaz:
https://doaj.org/article/311938837c58467bba910192a119c888
Autor:
Huang Su, Sakthivel Sekar, Sankar Seramani, Luc Ver Donck, Kishore Bhakoo, Joanne Garnell, Hilde Duytschaever, Joanes Grandjean, Roland Willems
Publikováno v:
Neuropharmacology, 146, pp. 109-116
Neuropharmacology, 146, 109-116
Neuropharmacology, 146, 109-116
Item does not contain fulltext Neuroimaging endophenotypes in animal models provide an objective and translationally-relevant alternative to cognitive/behavioral traits in human psychopathologies. Metabolic alterations, such as those involved in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74f56a9ce9cb57948feed15f8295944b
https://doi.org/10.1016/j.neuropharm.2018.11.021
https://doi.org/10.1016/j.neuropharm.2018.11.021
Publikováno v:
Pharmaceutical Statistics
Coadministration of 2 or more compounds can alter both the pharmacokinetics and pharmacodynamics of individual compounds. While experiments on pharmacodynamic drug-drug interactions are usually performed in an in vitro setting, this experiment focuse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99863c042255f2f8790e0076f6f7afd0
https://doi.org/10.1002/pst.1887
https://doi.org/10.1002/pst.1887
Autor:
Marcel J. C. Bijvelds, Natascha D.A. Nieuwenhuijze, Karine Smans, Kelly F. Meijsen, Ann Hellemans, Gary Tresadern, Joris H. De Maeyer, Jean-Pierre Bongartz, Hugo R. de Jonge, Luc Ver Donck, Jan A.J. Schuurkes
Publikováno v:
Journal of Biological Chemistry, 293(21), 8173-8181. American Society for Biochemistry and Molecular Biology Inc.
The Journal of Biological Chemistry
The Journal of Biological Chemistry
The guanosine 3′,5′-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII) serine/threonine kinase relays signaling through guanylyl cyclase C (GCC) to control intestinal fluid homeostasis. Here, we report the discovery of small-molecule
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a1ee4a8f9967179af8984be752279ac
https://hdl.handle.net/1765/107349
https://hdl.handle.net/1765/107349
Autor:
Marijke Somers, Gregor James Macdonald, Oscar Delgado, Fabrice Jourdan, Sergio A. Alonso de Diego, Michiel Van Gool, Andrés A. Trabanco, Luc Ver Donck
Publikováno v:
ChemMedChem. 12:905-912
The metabotropic glutamate subtype 2 (mGlu2 ) receptor is a presynaptic membrane receptor distributed widely in brain that provides feedback inhibitory control of glutamate release. Inhibition of the mGlu2 receptor function with a negative allosteric
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ce73e3dcd25d8447117186d96ecacef1
https://doi.org/10.1002/cmdc.201700101
https://doi.org/10.1002/cmdc.201700101
Autor:
Thomas Steckler, Michael K. Ameriks, Suchitra Ravula, Christine Dugovic, Luc Ver Donck, Alan D. Wickenden, Changlu Liu, Timothy W. Lovenberg, Nicholas I. Carruthers, Brian Lord, Nyantsz Wu, Sujin Yun, Jose A. Matta, Ryan M Wyatt, Brad M. Savall, Michael P. Maher
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 357:394-414
Members of the α-amino-3-hydroxyl-5-methyl-4-isoxazole-propionic acid (AMPA) subtype of ionotropic glutamate receptors mediate the majority of fast synaptic transmission within the mammalian brain and spinal cord, representing attractive targets for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7488b566cf60907bc2c6f463cd532b87
https://doi.org/10.1124/jpet.115.231712
https://doi.org/10.1124/jpet.115.231712
Autor:
Rupesh Nanjunda, Andre Marreiro, Astrid Bottelbergs, Tom Van De Casteele, Luc Ver Donck, Roland Willems, Marc Vandermeeren, John A. Kemp, Cindy Wintmolders, Kristof Van Kolen, Peter Paul De Deyn, Thomas J. Malia, Lore Delbroek, Cristiano Sousa, Debby Van Dam, Clara Theunis, Guy Daneels, Bruno Vasconcelos, Koen Dockx, M. Borgers, Marc Mercken, Eilyn R. Lacy
Publikováno v:
Journal of alzheimers disease, 65(1), 265-281. IOS Press
Journal of Alzheimer's disease
Journal of Alzheimer's disease
The tau spreading hypothesis provides rationale for passive immunization with an anti-tau monoclonal antibody to block seeding by extracellular tau aggregates as a disease-modifying strategy for the treatment of Alzheimer's disease (AD) and potential
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1317f66f775c6f76fa8530c7ca6d40b
https://research.rug.nl/en/publications/8e06689d-d8de-4ef6-a82c-eabafd8b0c89
https://research.rug.nl/en/publications/8e06689d-d8de-4ef6-a82c-eabafd8b0c89
Autor:
Marc Ceusters, Jodi L. Lukkes, Luc ver Donck, William A. Truitt, Justine M. Kent, Erik T. Dustrude, Andrei I. Molosh, Seema Bhatnagar, Pascal Bonaventure, Philip L. Johnson, Anantha Shekhar
Publikováno v:
Biological Psychiatry. 85:S30-S31
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7b81a8bb214e3c85f566c0626bb09fe1
https://doi.org/10.1016/j.biopsych.2019.03.088
https://doi.org/10.1016/j.biopsych.2019.03.088