Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Luc Van Nuffel"'
Autor:
Donald William Ludovici, Gilles Bignan, Carsten Schubert, Erwin Fraiponts, Karine Smans, Norbert Esser, Danielle Peeters, Michael H. Parker, Maxwell D. Cummings, Peter Vermeulen, Lieven Meerpoel, Sabine De Breucker, Tianbao Lu, Luc Van Nuffel, Richard Alexander, Bruce L. Grasberger, James R. Bischoff, Christian Rocaboy, Ron Gilissen, Christophe Meyer, Boudewijn Janssens, Peter J. Connolly
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:2159-2164
We designed and synthesized a new series of fatty acid synthase (FASN) inhibitors with potential utility for the treatment of cancer. Extensive SAR studies led to highly active FASN inhibitors with good cellular activity and oral bioavailability, exe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd313b43d21d3b1660d7723e4aead6d0
https://doi.org/10.1016/j.bmcl.2018.05.014
https://doi.org/10.1016/j.bmcl.2018.05.014
Autor:
Ulrike Philippar, Lorena Fontan, Ivo Cornelissen, Haopeng Rui, Sriram Balasubramanian, Marcello Gaudiano, Mariette Bekkers, Luc Van Nuffel, Tianbao Lu, John Wiener, Mark Tichenor, Tony Greway, Kathryn Packman, Bie Verbist, Yusri Elsayed, Ricardo Attar, Jacqueline Bussolari, John Gerecitano
Publikováno v:
Cancer Research. 81:1267-1267
Background: Constitutive activation of the classical nuclear factor kappa-light-chain-enhancer of activated B-cells (NF-κB) pathway is a clear driver of B-cell non-Hodgkin lymphomas (NHL). Bruton's Tyrosine Kinase (BTK) and Mucosa-associated lymphoi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7f55cce1586407af620b6db9d9bf1555
https://doi.org/10.1158/1538-7445.am2021-1267
https://doi.org/10.1158/1538-7445.am2021-1267
Autor:
Weimei Sun, James P. Edwards, Ricardo Attar, Tianbao Lu, Nigel Austin, Lieven Meerpoel, Ann Cai, Luc Gys, Ulrike Philippar, Maxwell D. Cummings, Kent Barbay, Peter J. Connolly, Luc Van Nuffel, Mariette Bekkers, Shen Fang
Publikováno v:
Bioorganicmedicinal chemistry letters. 29(23)
We describe a series of potent and highly selective small-molecule MALT1 inhibitors, optimized from a High-Throughput Screening hit. Advanced analogues such as compound 40 show high potency (IC50: 0.01 µM) in a biochemical assay measuring MALT1 enzy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13213f38b7f010206584e68d29659957
https://pubmed.ncbi.nlm.nih.gov/31678006
https://pubmed.ncbi.nlm.nih.gov/31678006
Autor:
Yann Abraham, Bart Petrus Anna Maria Jozef Medaer, Weimei Sun, Greet Vanhoof, Haopeng Rui, Yusri Elsayed, Sriram Balasubramanian, Ulrike Philippar, Marcello Gaudiano, Jan Willem Thuring, Jenna D. Goldberg, Tianbao Lu, Jennifer Smit, Peter J. Connolly, James P. Edwards, Max Cummings, Emanuele Trella, John Gerecitano, Nele Vloemans, Ricardo Attar, Tony Greway, Katarzyna Wnuk-Lipinska, Jan Linders, Kristof Kimpe, Amy J. Johnson, Jaqueline Bussolari, Bas-jan van der Leede, Luc Van Nuffel, Mariette Bekkers, Katie Amssoms
Publikováno v:
Blood Cancer Discovery. 1:PO-49
Introduction: Constitutive activation of the classical nuclear factor kappa-light-chain-enhancer of activated B cells (NF κB) pathway is a clear driver of B-cell lymphomas, especially the aggressive activated B-cell (ABC) subtype of diffuse large B-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0e8109699ae1dad100496dfd36f4ec75
https://doi.org/10.1158/2643-3249.lymphoma20-po-49
https://doi.org/10.1158/2643-3249.lymphoma20-po-49
Autor:
Ulrike Philippar, Tianbao Lu, Nele Vloemans, Mariette Bekkers, Luc Van Nuffel, Marcello Gaudiano, Katarzyna Wnuk-Lipinska, Bas-jan Van Der Leede, Katie Amssoms, Kristof Kimpe, Bart Medaer, Tony Greway, Yann Abraham, Max Cummings, Emanuele Trella, Greet Vanhoof, Weimei Sun, Jan Willem Thuring, Peter Connolly, Jan Linders, Haopeng Rui, Sriram Balasubramanian, Amy Johnson, John Gerecitano, Jenna Goldberg, James P. Edwards, Yusri Elsayed, Jennifer Smit, Jaqueline Bussolari, Ricardo Attar
Publikováno v:
Cancer Research. 80:5690-5690
Introduction: Constitutive activation of the classical nuclear factor kappa-light-chain-enhancer of activated B-cells (NF-κB) pathway is a clear driver of B-cell lymphomas, especially the aggressive activated B-cell (ABC) subtype of diffuse large B-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::504dd7a5e5c4ecf52e6e466854e7daea
https://doi.org/10.1158/1538-7445.am2020-5690
https://doi.org/10.1158/1538-7445.am2020-5690
Autor:
Juan Antonio Fernandez, Desire Massart, Luc Van Nuffel, Filip Woestenborghs, Frank C. Odds, Lieven Baert, Bisoen Rambali
Publikováno v:
Journal of Antimicrobial Chemotherapy. 48:163-177
A 2(10-5) fractional factorial model was used to investigate the influence of 10 process variables in broth microdilution susceptibility tests with itraconazole against eight isolates of Candida species and six isolates of filamentous fungi in two gr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ec6fcea1d35b25269f9c7a31a9d54f3
https://doi.org/10.1093/jac/48.2.163
https://doi.org/10.1093/jac/48.2.163
Publikováno v:
Journal of Clinical Microbiology. 36:2869-2873
To establish the historical prevalence of the novel yeast species Candida dubliniensis , a survey of 2,589 yeasts originally identified as Candida albicans and maintained in a stock collection dating back to the early 1970s was undertaken. A total of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7220ed1282a25c7dac2b9ed2790144e
https://doi.org/10.1128/jcm.36.10.2869-2873.1998
https://doi.org/10.1128/jcm.36.10.2869-2873.1998
Autor:
Lieven Meerpoel, Gilles Bignan, Luc Van Nuffel, Peter Vermeulen, Ron Gilissen, Tianbao Lu, Max Cummings, Christophe Meyer, Bruce L. Grasberger, Peter J. Connolly, Michael H. Parker, Erwin Fraiponts, Richard Alexander, Karine Smans, Boudewijn Janssens, Danielle Peeters, Norbert Esser, Donald William Ludovici, Carsten Schubert, James R. Bischoff, Sabine De Breucker
Publikováno v:
Cancer Research. 74:4747-4747
Fatty Acid Synthase (FASN) is a multi-domain protein that carries out de novo fatty acid (palmitate) synthesis from acetate and malonate in mammalian cells. FASN is up-regulated in cancer cells, providing fatty acid building blocks for rapid cell gro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bbc77f2de582fc793cad2cd350548d6d
https://doi.org/10.1158/1538-7445.am2014-4747
https://doi.org/10.1158/1538-7445.am2014-4747
Autor:
Lieven Meerpoel, James R. Bischoff, Carsten Schubert, Boudewijn Janssen, Geert Van Hecke, Erwin Fraiponts, Karine Smans, Luc Van Nuffel, Sabine De Breucker, Tianbao Lu, Michael H. Parker, Danielle Peeters, Yolanda T. Chong, Bruce L. Grasberger, Peter Vermeulen, Christophe Meyer, Ralph Graeser, Gilles Bignan, Suzana Vidic, Norbert Esser, Donald William Ludovici, Ron Gilissen, Peter J. Connolly
Publikováno v:
Cancer Research. 74:801-801
Fatty Acid Synthase (FASN) catalyzes the final step in palmitate (PA) synthesis, using acetyl-CoA, malonyl-CoA and NADPH. Most normal tissues express low levels of FASN and rely on uptake of fatty acids (FA) from the diet. It has been proposed that F
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a4a8ba06d36370068648ff2c8bc5179
https://doi.org/10.1158/1538-7445.am2014-801
https://doi.org/10.1158/1538-7445.am2014-801
Autor:
Carsten Schubert, Ron Gilissen, Bruce L. Grasberger, Christophe Meyer, Peter J. Connolly, Sabine De Breucker, Luc Van Nuffel, Norbert Esser, James R. Bischoff, Michael H. Parker, Donald William Ludovici, Erwin Fraiponts, Boudewijn Janssens, Danielle Peeters, Karine Smans, Tianbao Lu, Peter Vermeulen, Lieven Meerpoel, Gilles Bignan
Publikováno v:
Cancer Research. 74:2535-2535
De novo synthesis of fatty acids in mammalian cells is catalyzed by Fatty Acid Synthase (FASN), a complex dimeric protein with seven catalytic domains that processes acetyl-CoA and malonyl-CoA into palmitic acid. Palmitate and other fatty acids are e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5984cccf305d5033564ca0577f95f99e
https://doi.org/10.1158/1538-7445.am2014-2535
https://doi.org/10.1158/1538-7445.am2014-2535