Development of a novel NURR1/NOT agonist from hit to lead and candidate for the potential treatment of Parkinson's disease.

Autor: Lesuisse D; Rare and Neurologic Disease Research, Sanofi, 1 av Pierre Brossolette, Chilly Mazarin F-91935, France. Electronic address: dominique.lesuisse@sanofi.com., Malanda A; Medicinal Chemistry, Sanofi, 1 av Pierre Brossolette, Chilly Mazarin F-91385, France., Peyronel JF; Medicinal Chemistry, Sanofi, 1 av Pierre Brossolette, Chilly Mazarin F-91385, France., Evanno Y; Medicinal Chemistry, Sanofi, 1 av Pierre Brossolette, Chilly Mazarin F-91385, France., Lardenois P; Medicinal Chemistry, Sanofi, 1 av Pierre Brossolette, Chilly Mazarin F-91385, France., De-Peretti D; Medicinal Chemistry, Sanofi, 1 av Pierre Brossolette, Chilly Mazarin F-91385, France., Abécassis PY; DMPK, Sanofi, 13 quai Jules Guesde, Vitry-sur-Seine F-94403, France., Barnéoud P; Rare and Neurologic Disease Research, Sanofi, 1 av Pierre Brossolette, Chilly Mazarin F-91935, France., Brunel P; Preclinical Safety, Sanofi, 3, digue d' Alfortville, Alfortville F-94140, France., Burgevin MC; Translational Science, Sanofi, 1 av Pierre Brossolette, Chilly Mazarin F-91385, France., Cegarra C; Rare and Neurologic Disease Research, Sanofi, 1 av Pierre Brossolette, Chilly Mazarin F-91935, France., Auger F; Medicinal Chemistry, Sanofi, 1 av Pierre Brossolette, Chilly Mazarin F-91385, France., Dommergue A; Medicinal Chemistry, Sanofi, 1 av Pierre Brossolette, Chilly Mazarin F-91385, France., Lafon C; CNS Department, Sanofi, 195 route d'Espagne, F-31036 Toulouse, France., Even L; Medicinal Chemistry, Sanofi, 1 av Pierre Brossolette, Chilly Mazarin F-91385, France., Tsi J; Medicinal Chemistry, Sanofi, 1 av Pierre Brossolette, Chilly Mazarin F-91385, France., Luc TPH; Medicinal Chemistry, Sanofi, 1 av Pierre Brossolette, Chilly Mazarin F-91385, France., Almario A; Medicinal Chemistry, Sanofi, 1 av Pierre Brossolette, Chilly Mazarin F-91385, France., Olivier A; Translational Science, Sanofi, 1 av Pierre Brossolette, Chilly Mazarin F-91385, France., Castel MN; CNS Department, 13, quai Jules Guesde, F-94403 Vitry-sur-Seine Cedex, France., Taupin V; Rare and Neurologic Disease Research, Sanofi, 1 av Pierre Brossolette, Chilly Mazarin F-91935, France., Rooney T; Rare and Neurologic Disease Research, Sanofi, 1 av Pierre Brossolette, Chilly Mazarin F-91935, France., Vigé X; Translational Science, Sanofi, 1 av Pierre Brossolette, Chilly Mazarin F-91385, France.

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2019 Apr 01; Vol. 29 (7), pp. 929-932. Date of Electronic Publication: 2019 Jan 30.