Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Luc Rougée"'
Publikováno v:
Drug Metabolism and Disposition. 44:1819-1827
Surrogate assays for drug metabolism and inhibition are traditionally performed in buffer systems at pH 7.4, despite evidence that hepatocyte intracellular pH is 7.0. This pH gradient can result in a pKa-dependent change in intracellular/extracellula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ccd3c4c2801d6e9977a7953ba0eddfd
https://doi.org/10.1124/dmd.116.071761
https://doi.org/10.1124/dmd.116.071761
Autor:
David W. Bedwell, Luc Rougée, Jeff W Cramer, Nathan A Calvert, Nathan Yumibe, Kenneth J. Ruterbories, Kenneth C. Cassidy, Richard Moulton, Michael A. Mohutsky, Lisa A. Adams, Xin Zhou
Publikováno v:
Drug Metabolism and Disposition. 44:1184-1192
The Zucker diabetic fatty (ZDF) rat, an inbred strain of obese Zucker fatty rat, develops early onset of insulin resistance and displays hyperglycemia and hyperlipidemia. The phenotypic changes resemble human type 2 diabetes associated with obesity a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9e69d23677d8c4507f2e53434027c9b
https://doi.org/10.1124/dmd.116.070623
https://doi.org/10.1124/dmd.116.070623
Publikováno v:
Drug Metabolism and Disposition. 44:967-974
The NADPH dehydrogenase quinone oxido-reductase 1 (NQO1) enzyme is an antioxidant and metabolic enzyme that performs two electron reduction of quinones and other chemicals. Based on the physiologic role(s) of NQO1, we hypothesized that expression and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::534398069b30fa3d6218b509b782650b
https://doi.org/10.1124/dmd.115.068650
https://doi.org/10.1124/dmd.115.068650
Publikováno v:
Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology. 189:38-44
Coral reefs are an indispensible worldwide resource, accounting for billions of dollars in cultural, economic, and ecological services. An understanding of coral reproduction is essential to determining the effects of environmental stressors on coral
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5187ab2fcfa8231ac96809059c9307ad
https://doi.org/10.1016/j.cbpa.2015.07.012
https://doi.org/10.1016/j.cbpa.2015.07.012
Publikováno v:
Drug Metabolism Letters. 9:88-98
Obesity in children is a significant clinical concern. There are many anecdotes and case studies regarding specific reactions of obese children to medications including therapeutic failure, adverse drug reactions and/or requirements for higher weight
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f433d12ce84f97a379df5295224771f0
https://doi.org/10.2174/1872312809666150804111612
https://doi.org/10.2174/1872312809666150804111612
Publikováno v:
Drug Metabolism and Disposition. 42:1921-1925
The UDP-glucuronosyltransferase (UGT) enzymes are critical for regulating nutrients, hormones, and endobiotics, as well as for detoxifying xenobiotics. Human and murine fetuses are known to express glucuronidation enzymes, but there are currently no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9315b8f7da770cf064e39956fa4948db
https://doi.org/10.1124/dmd.114.059766
https://doi.org/10.1124/dmd.114.059766
Publikováno v:
Coral Reefs. 33:523-535
The continued deterioration of coral reefs worldwide demonstrates the need to develop diagnostic tools for corals that go beyond general ecological monitoring and can identify specific stressors at sublethal levels. Cellular diagnostics present an ap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d41488a1e4cc1bae1dae9fe071a70b5
https://doi.org/10.1007/s00338-014-1136-3
https://doi.org/10.1007/s00338-014-1136-3
Autor:
Robert H. Richmond, David E. Williams, Jackalyn Holbrook, Wendy Mendiola, Craig A. Downs, Luc Rougée, Sean Knutson, Teina Rongo, Gary K. Ostrander
Publikováno v:
Ecotoxicology (London, England). 21(3)
Coral reefs throughout the world are exhibiting documented declines in coral cover and species diversity, which have been linked to anthropogenic stressors including land-based sources of pollution. Reductions in coastal water and substratum quality
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09604b94994bc1a7a7f86abc8de97968
https://pubmed.ncbi.nlm.nih.gov/22215560
https://pubmed.ncbi.nlm.nih.gov/22215560
Autor:
Luc Rougée, A. Alonso Aguirre, Bruce A. Wilcox, Yuanan Lu, Fangxing Yang, Ying Xu, Shiwei Jin
Publikováno v:
Chemosphere. 73(1)
The purpose of this study was to investigate polychlorinated biphenyls (PCBs) contamination in tilapia (Oreochromis mossambicus) collected from the Manna stream and Ala Wai Canal of O'ahu, an island of the geographically isolated Hawaiian archipelago
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b81d69b3212d03de38bc0c9de5c8747
https://pubmed.ncbi.nlm.nih.gov/18561981
https://pubmed.ncbi.nlm.nih.gov/18561981
Publikováno v:
Diseases of aquatic organisms. 77(2)
Goldfish Carassius auratus are common aquarium fish and have a significant economic and research value, having considerable worth to fisheries as a baitfish and the ability to adapt to a range of habitats. Two cell lines were established from goldfis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5b975a560629ce49cbd8aa479cdc857
https://pubmed.ncbi.nlm.nih.gov/17972754
https://pubmed.ncbi.nlm.nih.gov/17972754