Výsledky vyhledávání - "Luc Rocheblave"

Akademický článek

In vitro modulation of multidrug resistance by pregnane steroids and in vivo inhibition of tumour development by 7α-OBz-11α(R)-OTHP-5β-pregnanedione in K562/R7 and H295R cell xenografts

Autor: Ghina Alameh, Agnès Emptoz-Bonneton, Marc Rolland de Ravel, Eva L. Matera, Elisabeth Mappus, Patrick Balaguer, Luc Rocheblave, Thierry Lomberget, Charles Dumontet, Marc Le Borgne, Michel Pugeat, Catherine Grenot, Claude Y. Cuilleron

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 684-691 (2019)

Synthetic progesterone and 5α/β-pregnane-3,20-dione derivatives were evaluated as in vitro and in vivo modulators of multidrug-resistance (MDR) using two P-gp-expressing human cell lines, the non-steroidogenic K562/R7 erythroleukaemia cells and the

Externí odkaz: https://doaj.org/article/55b0290ee7904a11adb07838554e6862

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Akademický článek

Spectral data for the synthesis of (E)-alkenylboronic acid pinacol esters via hydroboration of alkynes

Autor: Bruna Gioia, Alexandre Arnaud, Sylvie Radix, Nadia Walchshofer, Anne Doléans-Jordheim, Luc Rocheblave

Publikováno v: Data in Brief, Vol 30, Iss , Pp 105354- (2020)

This data article is related to a research paper entitled “Solvent- and metal-free hydroboration of alkynes under microwave irradiation” (Gioia et al. TETL-D-19-01698) [1]. Herein we present the spectral data acquired from the synthesis of (E)-al

Externí odkaz: https://doaj.org/article/350ffb3f9e964e6fa24424fda673ea57

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Solvent- and metal-free hydroboration of alkynes under microwave irradiation

Autor: Alexandre Arnaud, Sylvie Radix, Anne Doléans-Jordheim, Luc Rocheblave, Nadia Walchshofer, Bruna Gioia

Publikováno v: Tetrahedron Letters
Tetrahedron Letters, Elsevier, 2020, ⟨10.1016/j.tetlet.2020.151596⟩

Boronic esters are versatile building blocks extensively used in organic chemistry and essential to a variety of coupling reactions. In this work, the hydroboration reactions of alkynes were performed without metal catalysts using concomitant microwa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccc1f64464e2e88e11a02469808c00f6
https://hal.archives-ouvertes.fr/hal-02443839

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In vitro modulation of multidrug resistance by pregnane steroids and in vivo inhibition of tumour development by 7α-OBz-11α(R)-OTHP-5β-pregnanedione in K562/R7 and H295R cell xenografts

Autor: Luc Rocheblave, Thierry Lomberget, Patrick Balaguer, Charles Dumontet, Eva Laure Matera, Catherine Grenot, Claude Y Cuilleron, Ghina Alameh, E Mappus, Agnès Emptoz-Bonneton, Michel Pugeat, Marc Rolland de Ravel, Marc Le Borgne

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry
Journal of Enzyme Inhibition and Medicinal Chemistry, Informa Healthcare, 2019, 34 (1), pp.684-691. ⟨10.1080/14756366.2019.1575825⟩
Journal of Enzyme Inhibition and Medicinal Chemistry, 2019, 34 (1), pp.684-691. ⟨10.1080/14756366.2019.1575825⟩
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 684-691 (2019)

International audience; Synthetic progesterone and 5α/β-pregnane-3,20-dione derivatives were evaluated as in vitro and in vivo modulators of multidrug-resistance (MDR) using two P-gp-expressing human cell lines, the non-steroidogenic K562/R7 erythr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f99c031fa0528de7af7dd78aa823532
https://hal.archives-ouvertes.fr/hal-02077612/document

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N,N′-disubstituted cinnamamide derivatives potentiate ciprofloxacin activity against overexpressing NorA efflux pump Staphylococcus aureus 1199B strains

Autor: Luc Rocheblave, Nadia Walchshofer, Carine Commun, Marie-Geneviève Dijoux-Franca, Sylvie Radix, Angélique Mularoni, Serge N'Digo, Serge Michalet, Anne Doléans Jordheim, Anne-Laure Prignon

Publikováno v: European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, Elsevier, 2018, 150, pp.900-907. ⟨10.1016/j.ejmech.2018.03.028⟩
European Journal of Medicinal Chemistry, Elsevier, 2018, 150, pp.900-907. 〈10.1016/j.ejmech.2018.03.028〉

International audience; A multi-step procedure has been described which afforded satisfactory yields of N,N 0-disubstituted cinnamamides derived from N-Boc-protected amino acids (Boc-Gly, Boc-Val, Boc-Phe). The key step of this synthesis was a regios

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cf917b6327fc6092f10bf21d46a963f
https://hal.archives-ouvertes.fr/hal-01763023

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Synthesis of 12-oxa, 12-aza and 12-thia cholanetriols

Autor: Malika Ibrahim-Ouali, Khalil Hamze, Luc Rocheblave

Publikováno v: Steroids. 76:324-330

An efficient synthesis of 12-hetero steroids was achieved via a Baeyer–Villiger oxidation and a photolysis as the key steps. We set out to describe in this paper the first synthesis of 12-aza steroids. The characteristic 1 H and 13 C NMR spectrosco

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8bd77a1aeb7927ae4b6131d13972c00
https://doi.org/10.1016/j.steroids.2010.12.003

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First synthesis of thia steroids from cholic acid

Autor: Malika Ibrahim-Ouali, Luc Rocheblave

Publikováno v: Steroids. 75:701-709

Heterosteroids remain interesting due to their potential biological activities. This prompted us to synthesize novel thia steroids possessing the heteroatom in the A-ring. We set out to describe a new and versatile method for preparing 3-thia steroid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1ca965c35574aa9a3c840eb22aa7873
https://doi.org/10.1016/j.steroids.2010.04.006

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Synthesis of new steroidal inhibitors of P-glycoprotein-mediated multidrug resistance and biological evaluation on K562/R7 erythroleukemia cells

Autor: Sonia Beltran, Nadia Walchshofer, Marc Le Borgne, Roland Barret, Agnès Emptoz-Bonneton, Charles Dumontet, Michel Pugeat, Catherine Grenot, Zahia Mahiout, Maxime Melikian, Eva-Laure Matera, Lucienne El Jawad, Ghina Alameh, Elisabeth Mappus, Luc Rocheblave, Marc Rolland de Ravel, Claude Yves Cuilleron, Thierry Lomberget

Publikováno v: Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, American Chemical Society, 2015, 58 (4), pp.1832-1845. ⟨10.1021/jm501676v⟩

A simple route for improving the potency of progesterone as a modulator of P-gp-mediated multidrug resistance was established by esterification or etherification of hydroxylated 5α/β-pregnane-3,20-dione or 5β-cholan-3-one precursors. X-ray crystal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::195f7e504ec6642dbda35ee91f446dd4
https://pubmed.ncbi.nlm.nih.gov/25634041

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Studies toward Taxuspine X, a potent multidrug-resistance reversing agent, via ring closing metathesis strategy

Autor: Luc Rocheblave, Michela L. Renzulli, Federico Corelli, Maurizio Botta, Stanislava I. Avramova

Publikováno v: Tetrahedron Letters. 45:5155-5158

The synthesis of bicyclic 3,8-secotaxane diterpenoids, which includes Taxuspine U and X, has been achieved through an approach that involves a ring closing metathesis reaction as key step for the macrocycle formation.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d3b9ff9c4232ba4d327438693113ebc5
https://doi.org/10.1016/j.tetlet.2004.04.147

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