Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Luc Quere"'
Autor:
Morgane Sanselme, Sandrine Rome, Luc Quere, Johan Wouters, Yohann Cartigny, Luc Aerts, Frederic De Smet, Gérard Coquerel, Nicolas Couvrat
Publikováno v:
Crystal Growth & Design
Crystal Growth & Design, American Chemical Society, 2018, 18 (9), pp.4807-4810. ⟨10.1021/acs.cgd.8b00331⟩
Crystal Growth & Design, American Chemical Society, 2018, 18 (9), pp.4807-4810. ⟨10.1021/acs.cgd.8b00331⟩
This article highlights the unusual behavior of brivaracetam (BRV: An active pharmaceutical ingredient against epilepsy), which leads to a unique phase-ranging from clathrate to solvate to cocrystal-formed with an impressive number of apolar guest mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba2e9e2ee5ca482a137967d6841bd2ad
https://doi.org/10.1021/acs.cgd.8b00331
https://doi.org/10.1021/acs.cgd.8b00331
Autor:
Alexandre Tkatchenko, Marcus A. Neumann, Majid Mortazavi, Jacco van de Streek, Johannes Hoja, Luc Aerts, Luc Quere
Publikováno v:
Communications Chemistry, Vol 2, Iss 1, Pp 1-1 (2019)
In the original version of this Article, there was an error in the address for affiliation 4. This has now been corrected in both the PDF and HTML versions of the Article.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3f5fbe2b10b4b80a331d39346338556
https://doi.org/10.1038/s42004-019-0181-9
https://doi.org/10.1038/s42004-019-0181-9
Autor:
Johannes Hoja, Luc Quere, Marcus A. Neumann, Majid Mortazavi, Luc Aerts, Alexandre Tkatchenko, Jacco van de Streek
Publikováno v:
Communications Chemistry, 2, 70. London, United Kingdom: Springer Nature (2019).
Communications Chemistry
Communications Chemistry, Vol 2, Iss 1, Pp 1-7 (2019)
Communications Chemistry
Communications Chemistry, Vol 2, Iss 1, Pp 1-7 (2019)
The active pharmaceutical ingredient rotigotine—a dopamine agonist for the treatment of Parkinson’s and restless leg diseases—was known to exist in only one polymorphic form since 1985. In 2008, the appearance of a thermodynamically more stable
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbbf6a2b2284046278229e38f15d3fd3
https://doi.org/10.1038/s42004-019-0171-y
https://doi.org/10.1038/s42004-019-0171-y
Publikováno v:
Polymorphism in the Pharmaceutical Industry
The relevance of co‐crystals for pharmaceutical development is demonstrated by the constant growth of the number of papers and patents published in the two last decades. Co‐crystallization appears to be an efficient means to modulate the solid st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::776a6d1ba3f158d80e12f207e028129b
https://doi.org/10.1002/9783527697847.ch3
https://doi.org/10.1002/9783527697847.ch3
Autor:
Julien Mahieux, Luc Quere, Luc Aerts, Gérard Coquerel, Eric Schenkel, Nicolas Couvrat, Baptiste Fours, Yohann Cartigny
Publikováno v:
International Journal of Pharmaceutics
International Journal of Pharmaceutics, Elsevier, 2016, 515 (1-2), pp.702-707. ⟨10.1016/j.ijpharm.2016.11.003⟩
International Journal of Pharmaceutics, Elsevier, 2016, 515 (1-2), pp.702-707. ⟨10.1016/j.ijpharm.2016.11.003⟩
Brivaracetam, or (2S)-2-[(4R)-2-oxo-4-propyl-pyrrolidin-1-yl] butanamide, is an active pharmaceutical ingredient designed for the treatment of epilepsy. During the development of the IV administration mode, a liquid-liquid miscibility gap has been ob
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72acd17ddd05efaa6f8243fbef813aef
https://hal-normandie-univ.archives-ouvertes.fr/hal-01928640
https://hal-normandie-univ.archives-ouvertes.fr/hal-01928640
Autor:
Iwan J. P. de Esch, Yves Lamberty, Patrice Talaga, Valérie Verbois, Rob Leurs, Frédéric Denonne, Florence Lebon, Alain Vanbellinghen, Bernard Christophe, Michel Gillard, Christel Delaunoy, Sylvain Celanire, Edith Gelens, Erwin Snip, Henk Timmerman, Donald Dassesse, Nathalie Van houtvin, Laurent Provins, Benedicte Lallemand, Véronique Durieu, Philippe Collart, Jean-Marie Nicolas, Maikel Wijtmans, Luc Quere
Publikováno v:
ChemMedChem, 4(7), 1063-8. John Wiley and Sons Ltd
Celanire, S, Wijtmans, M, Christophe, B, Collart, P, de Esch, I J P, Dassesse, D, Delaunoy, C, Denonne, F, Durieu, V, Gelens, E, Gillard, M, Lallemand, B, Lamberty, Y, Lebon, F, Nicolas, J M, Quere, L, Snip, E, Vanbellinghen, A, Van Houtvin, N, Verbois, V, Timmerman, H, Talaga, P, Leurs, R & Provins, L 2009, ' Discovery of a new class of non-imidazole oxazoline-based histamine H(3) receptor (H(3)R) inverse agonists ', ChemMedChem, vol. 4, no. 7, pp. 1063-8 . https://doi.org/10.1002/cmdc.200900055
Celanire, S, Wijtmans, M, Christophe, B, Collart, P, de Esch, I J P, Dassesse, D, Delaunoy, C, Denonne, F, Durieu, V, Gelens, E, Gillard, M, Lallemand, B, Lamberty, Y, Lebon, F, Nicolas, J M, Quere, L, Snip, E, Vanbellinghen, A, Van Houtvin, N, Verbois, V, Timmerman, H, Talaga, P, Leurs, R & Provins, L 2009, ' Discovery of a new class of non-imidazole oxazoline-based histamine H(3) receptor (H(3)R) inverse agonists ', ChemMedChem, vol. 4, no. 7, pp. 1063-8 . https://doi.org/10.1002/cmdc.200900055
H(3)R inverse agonists based on an aminopropoxy-phenyloxazoline framework constitute highly valuable druglike lead compounds that display efficacy in a mouse model of recognition memory.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::543d6a72ee98e4081c29c96d0b654379
https://doi.org/10.1002/cmdc.200900055
https://doi.org/10.1002/cmdc.200900055
Autor:
Pierre Danhaive, Laurent Provins, Jacques Dulieu, Karin J. Stebbins, Luc Quere, Michel Gillard, Bernard Christophe
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:3077-3080
Introduction of 3-substituted azetidinyl substituents onto the 4,6-diaminopyrimidine scaffold allowed the improvement of PDE4 inhibiting activities. Preliminary in vivo activity in pulmonary inflammation models is reported.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c797927517c7c8fc2ec2198e1dc15c0c
https://doi.org/10.1016/j.bmcl.2007.03.047
https://doi.org/10.1016/j.bmcl.2007.03.047
Autor:
Laurent Knerr, Marie-Agnes Lassoie, Valérie Verbois, Fabienne Broeders, Gérald Guillaumet, Laurent Provins, Abdoulaye Gassama, Stéphanie Norsikian, Françoise de Laveleye-Defais, Philippe Collart, Laurent Defrère, Laszlo Kiss, Luc Quere, Jean-Marie Nicolas, Jean-Claude Hayez, Thierry Demaude, Sylvain Routier
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:142-146
A new series of 2,6-quinolinyl derivatives was prepared leading to potent low nanomolar VLA-4/VCAM-1 antagonists.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa5d4aa4d7b87e63c2fcf492b1df4495
https://doi.org/10.1016/j.bmcl.2006.09.069
https://doi.org/10.1016/j.bmcl.2006.09.069
Autor:
Bernard Christophe, T. Taverne, Patrick Pasau, Jean-Pierre Hénichart, Christophe Genicot, Florence Moureau, Luc Quere, Laurence Goossens, B. J. Van Keulen, Michel Gillard, Marie-Agnes Lassoie, Philippe Collart, Thomas Ryckmans, F. Stiernet, Jean-Marie Nicolas, Michel Neuwels
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:437-442
Benzyloxyphenethylpiperazines are a new class of high affinity NK1 receptor antagonists. Oral bioavailability and selectivity can be fine tuned by the nature of the substituents on the basic nitrogen atom. Addition of substituents with a carboxylic a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06f934cf18d1ae07e1b0903847f27e43
https://doi.org/10.1016/s0960-894x(02)00956-3
https://doi.org/10.1016/s0960-894x(02)00956-3
Publikováno v:
European Journal of Pharmacology. 441:35-45
Vascular diseases like thrombosis, myocardial infarction, cerebral ischemia or chronic venous insufficiency affect a high proportion of the population. They are all associated with more or less pronounced ischemic conditions. We have previously shown
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b84ee088684f05b35d9890c2c2b6362f
https://doi.org/10.1016/s0014-2999(02)01490-5
https://doi.org/10.1016/s0014-2999(02)01490-5