Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Luc Penicaud"'
Autor:
Lucie Desmoulins, Chloé Chrétien, Romain Paccoud, Stephan Collins, Céline Cruciani-Guglielmacci, Anne Galinier, Fabienne Liénard, Aurore Quinault, Sylvie Grall, Camille Allard, Claire Fenech, Lionel Carneiro, Thomas Mouillot, Audren Fournel, Claude Knauf, Christophe Magnan, Xavier Fioramonti, Luc Pénicaud, Corinne Leloup
Publikováno v:
Molecular Metabolism, Vol 20, Iss , Pp 166-177 (2019)
Objective: Hypothalamic glucose sensing (HGS) initiates insulin secretion (IS) via a vagal control, participating in energy homeostasis. This requires mitochondrial reactive oxygen species (mROS) signaling, dependent on mitochondrial fission, as show
Externí odkaz:
https://doaj.org/article/ada7184d966e4b8ca92e1f682c8588f0
Autor:
Danaé Nuzzaci, Céline Cansell, Fabienne Liénard, Emmanuelle Nédélec, Selma Ben Fradj, Julien Castel, Ewout Foppen, Raphael Denis, Dominique Grouselle, Amélie Laderrière, Aleth Lemoine, Alexia Mathou, Virginie Tolle, Tony Heurtaux, Xavier Fioramonti, Etienne Audinat, Luc Pénicaud, Jean-Louis Nahon, Carole Rovère, Alexandre Benani
Publikováno v:
Cell Reports, Vol 30, Iss 9, Pp 3067-3078.e5 (2020)
Summary: Mechanistic studies in rodents evidenced synaptic remodeling in neuronal circuits that control food intake. However, the physiological relevance of this process is not well defined. Here, we show that the firing activity of anorexigenic POMC
Externí odkaz:
https://doaj.org/article/d5284aaafefd4a588b4cedece0e6efec
Autor:
Xavier Brenachot, Emmanuelle Nédélec, Selma Ben Fradj, Gaelle Boudry, Véronique Douard, Amélie Laderrière, Aleth Lemoine, Fabienne Liénard, Danaé Nuzzaci, Luc Pénicaud, Caroline Rigault, Alexandre Benani
Publikováno v:
Frontiers in Nutrition, Vol 5 (2018)
High variability exists in individual susceptibility to develop overweight in an obesogenic environment and the biological underpinnings of this heterogeneity are poorly understood. In this brief report, we show in mice that the vulnerability to diet
Externí odkaz:
https://doaj.org/article/339fc6dabc1c428faed4cf1c5ddd70f1
Autor:
Aurore Quinault, Corinne Leloup, Geoffrey Denwood, Coralie Spiegelhalter, Marianne Rodriguez, Philippe Lefebvre, Nadia Messaddeq, Quan Zhang, Catherine Dacquet, Luc Pénicaud, Stephan C Collins
Publikováno v:
PLoS ONE, Vol 13, Iss 3, p e0193882 (2018)
The rhythmic nature of insulin secretion over the 24h cycle in pancreatic islets has been mostly investigated using transcriptomics studies showing that modulation of insulin secretion over this cycle is achieved via distal stages of insulin secretio
Externí odkaz:
https://doaj.org/article/c46fa100786648a0904e9fb9fed8d2e5
Publikováno v:
Frontiers in Physiology, Vol 8 (2017)
The hypothalamus have been recognized for decades as one of the major brain centers for the control of energy homeostasis. This area contains specialized neurons able to detect changes in nutrients level. Among them, glucose-sensing neurons use gluco
Externí odkaz:
https://doaj.org/article/dcabb17424c34280aa7e9911a33d663e
Autor:
Xavier Brenachot, Thomas Gautier, Emmanuelle Nédélec, Valérie Deckert, Amélie Laderrière, Danaé Nuzzaci, Caroline Rigault, Aleth Lemoine, Luc Pénicaud, Laurent Lagrost, Alexandre Benani
Publikováno v:
Frontiers in Neuroscience, Vol 11 (2017)
The polysialic acid (PSA) is a large glycan that is added to cell-surface proteins during their post-translational maturation. In the brain, PSA modulates distances between cells and controls the plasticity of the nervous system. In the hypothalamus,
Externí odkaz:
https://doaj.org/article/b12fea4e6059444394a8f6ec63b4250e
Autor:
Anne-Catherine Maurin, Alexandre Benani, Anne Lorsignol, Xavier Brenachot, Laurent Parry, Valérie Carraro, Christophe Guissard, Julien Averous, Céline Jousse, Alain Bruhat, Cédric Chaveroux, Wafa B’chir, Yuki Muranishi, David Ron, Luc Pénicaud, Pierre Fafournoux
Publikováno v:
Cell Reports, Vol 6, Iss 3, Pp 438-444 (2014)
The reversible phosphorylation of the α subunit of eukaryotic initiation factor 2 (eIF2α) is a highly conserved signal implicated in the cellular adaptation to numerous stresses such as the one caused by amino acid limitation. In response to dietar
Externí odkaz:
https://doaj.org/article/2ce376b4b55e420095cd6256dc033a52
Autor:
Valentine S Moullé, Christelle Le Foll, Erwann Philippe, Nadim Kassis, Claude Rouch, Nicolas Marsollier, Linh-Chi Bui, Christophe Guissard, Julien Dairou, Anne Lorsignol, Luc Pénicaud, Barry E Levin, Céline Cruciani-Guglielmacci, Christophe Magnan
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e74021 (2013)
Variations in plasma fatty acid (FA) concentrations are detected by FA sensing neurons in specific brain areas such as the hypothalamus. These neurons play a physiological role in the control of food intake and the regulation of hepatic glucose produ
Externí odkaz:
https://doaj.org/article/749e6df341bd4cf786146613e7bb071f
Autor:
Alexandra Gouazé, Xavier Brenachot, Caroline Rigault, Alice Krezymon, Camille Rauch, Emmanuelle Nédélec, Aleth Lemoine, Jean Gascuel, Sylvian Bauer, Luc Pénicaud, Alexandre Benani
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e72029 (2013)
The hypothalamus plays a crucial role in the control of the energy balance and also retains neurogenic potential into adulthood. Recent studies have reported the severe alteration of the cell turn-over in the hypothalamus of obese animals and it has
Externí odkaz:
https://doaj.org/article/cf5798e030f4437394f7b991468be247
Autor:
Xavier Fioramonti, Adam Deak, Srinidhi Deshpande, Lionel Carneiro, Chunxue Zhou, Nazish Sayed, Branly Orban, Joshua R Berlin, Luc Pénicaud, Corinne Leloup, Annie Beuve, Vanessa H Routh
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e68709 (2013)
Hypoglycemia is a severe side effect of intensive insulin therapy. Recurrent hypoglycemia (RH) impairs the counter-regulatory response (CRR) which restores euglycemia. During hypoglycemia, ventromedial hypothalamus (VMH) production of nitric oxide (N
Externí odkaz:
https://doaj.org/article/a5bd273ea0b94bd5b7ddbdc809114a25