Zobrazeno 1 - 10
of 214
pro vyhledávání: '"Luc J. W. van der Laan"'
Autor:
Zhenguo Wang, Chen Xing, Luc J. W. van der Laan, Monique M. A. Verstegen, Bart Spee, Rosalinde Masereeuw
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Background Drug induced bile duct injury is a frequently observed clinical problem leading to a wide range of pathological features. During the past decades, several agents have been identified with various postulated mechanisms of bile duct
Externí odkaz:
https://doaj.org/article/8d28353034a843c4be8fec25debc89e5
Autor:
Ruby Lieshout, Alessandra V. S. Faria, Maikel P. Peppelenbosch, Luc J. W. van der Laan, Monique M. A. Verstegen, Gwenny M. Fuhler
Publikováno v:
Molecular Medicine, Vol 28, Iss 1, Pp 1-15 (2022)
Abstract Background Cholangiocarcinoma is a rare but lethal cancer of the biliary tract. Its first-line treatment is currently restricted to chemotherapy, which provides limited clinical benefit. Kinase inhibitors targeting oncogenic intracellular si
Externí odkaz:
https://doaj.org/article/383639e6c871433fabdfa2e494969105
Autor:
Ivo J. Schurink, Jubi E. de Haan, Jorke Willemse, Matteo Mueller, Michael Doukas, Henk Roest, Femke H. C. de Goeij, Wojciech G. Polak, Jan N. M. Ijzermans, Philipp Dutkowski, Luc J. W. van der Laan, Jeroen de Jonge
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract No single reliable parameter exists to assess liver graft function of extended criteria donors during ex-vivo normothermic machine perfusion (NMP). The liver maximum capacity (LiMAx) test is a clinically validated cytochromal breath test, me
Externí odkaz:
https://doaj.org/article/dedd368854184c698545abb8ed497bf8
Autor:
Luan Nguyen, Myrthe Jager, Ruby Lieshout, Petra E. de Ruiter, Mauro D. Locati, Nicolle Besselink, Bastiaan van der Roest, Roel Janssen, Sander Boymans, Jeroen de Jonge, Jan N. M. IJzermans, Michail Doukas, Monique M. A. Verstegen, Ruben van Boxtel, Luc J. W. van der Laan, Edwin Cuppen, Ewart Kuijk
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-9 (2021)
Nguyen et al. used liver organoid cultures to identify all somatic mutations in individual stem cells from patients with common liver diseases that confer risk of cancer. The authors report that, compared to healthy liver, these precancerous liver di
Externí odkaz:
https://doaj.org/article/96839cce3bec43feb376e5547a803268
Publikováno v:
BMC Biotechnology, Vol 21, Iss 1, Pp 1-11 (2021)
Abstract Background Extracellular microRNAs (miRNAs), released from cells into biofluids, have emerged as promising biomarkers for diagnostic and prognostic purposes. Several RNA isolation methods are available for the analysis of these cell-free miR
Externí odkaz:
https://doaj.org/article/6452699183504519ae8fa389a127163c
Autor:
Vincent T. Janmaat, Kateryna Nesteruk, Manon C. W. Spaander, Auke P. Verhaar, Bingting Yu, Rodrigo A. Silva, Wayne A. Phillips, Marcin Magierowski, Anouk van de Winkel, H. Scott Stadler, Tatiana Sandoval-Guzmán, Luc J. W. van der Laan, Ernst J. Kuipers, Ron Smits, Marco J. Bruno, Gwenny M. Fuhler, Nicholas J. Clemons, Maikel P. Peppelenbosch
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Barrett’s esophagus is a pro-oncogenic lesion in the proximal gastrointestinal tract, but with a distal colon-like morphology. Here the authors report that the distal HOX gene HOXA13 is expressed in Barrett’s esophagus and in single cells of the
Externí odkaz:
https://doaj.org/article/469f4cbf24264d01b938927512f6b9a2
Autor:
Zhenguo Wang, João Faria, Luc J. W. van der Laan, Louis C. Penning, Rosalinde Masereeuw, Bart Spee
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 10 (2022)
Liver diseases affect hundreds of millions of people worldwide; most often the hepatocytes or cholangiocytes are damaged. Diseases of the biliary tract cause severe patient burden, and cholangiocytes, the cells lining the biliary tract, are sensitive
Externí odkaz:
https://doaj.org/article/cab7f83ee5244511aa9e4af4fb961bd8
Autor:
Shaojun Shi, Eliano Bonaccorsi-Riani, Ivo Schurink, Thierry van den Bosch, Michael Doukas, Karishma A. Lila, Henk P. Roest, Daela Xhema, Pierre Gianello, Jeroen de Jonge, Monique M. A. Verstegen, Luc J. W. van der Laan
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
BackgroundEarly allograft dysfunction (EAD) following liver transplantation (LT) remains a major threat to the survival of liver grafts and recipients. In animal models, it is shown that hepatic ischemia-reperfusion injury (IRI) triggers phosphorylat
Externí odkaz:
https://doaj.org/article/4184753522194290ab7915f74df08c32
Autor:
Lotta Hof, Till Moreth, Michael Koch, Tim Liebisch, Marina Kurtz, Julia Tarnick, Susanna M. Lissek, Monique M. A. Verstegen, Luc J. W. van der Laan, Meritxell Huch, Franziska Matthäus, Ernst H. K. Stelzer, Francesco Pampaloni
Publikováno v:
BMC Biology, Vol 19, Iss 1, Pp 1-22 (2021)
Abstract Background Organoids are morphologically heterogeneous three-dimensional cell culture systems and serve as an ideal model for understanding the principles of collective cell behaviour in mammalian organs during development, homeostasis, rege
Externí odkaz:
https://doaj.org/article/985f7b88103b4a6eb9b07b3469ea7f06
Autor:
Monique M. A. Verstegen, Floris J. M. Roos, Ksenia Burka, Helmuth Gehart, Myrthe Jager, Maaike de Wolf, Marcel J. C. Bijvelds, Hugo R. de Jonge, Arif I. Ardisasmita, Nick A. van Huizen, Henk P. Roest, Jeroen de Jonge, Michael Koch, Francesco Pampaloni, Sabine A. Fuchs, Imre F. Schene, Theo M. Luider, Hubert P. J. van der Doef, Frank A. J. A. Bodewes, Ruben H. J. de Kleine, Bart Spee, Gert-Jan Kremers, Hans Clevers, Jan N. M. IJzermans, Edwin Cuppen, Luc J. W. van der Laan
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-16 (2020)
Abstract The development, homeostasis, and repair of intrahepatic and extrahepatic bile ducts are thought to involve distinct mechanisms including proliferation and maturation of cholangiocyte and progenitor cells. This study aimed to characterize hu
Externí odkaz:
https://doaj.org/article/eb9e7d98f7234f40b94f21db6d99f8db