Zobrazeno 1 - 10
of 279
pro vyhledávání: '"Luc G. T. Morris"'
Autor:
Ofra Novoplansky, Avital B. Shnerb, Divyasree Marripati, Sankar Jagadeeshan, Raghda Abu Shareb, Cristina Conde‐López, Jonathan Zorea, Manu Prasad, Talal Ben Lulu, Ksenia M. Yegodayev, Chen Benafsha, Yushi Li, Dexin Kong, Fengshen Kuo, Luc G. T. Morris, Ina Kurth, Jochen Hess, Moshe Elkabets
Publikováno v:
Molecular Oncology, Vol 17, Iss 12, Pp 2618-2636 (2023)
Blocking the mitogen‐activated protein kinase (MAPK) pathway with the MEK1/2 inhibitor trametinib has produced promising results in patients with head and neck squamous cell carcinoma (HNSCC). In the current study, we showed that trametinib treatme
Externí odkaz:
https://doaj.org/article/dfae4467864b4fe58887dab33f08a3c3
Autor:
Sven Liebig, Martin Neumann, Patricia Silva, Jutta Ortiz-Tanchez, Veronika Schulze, Konstandina Isaakidis, Cornelia Schlee, Michael P. Schroeder, Thomas Beder, Luc G. T. Morris, Timothy A. Chan, Lorenz Bastian, Thomas Burmeister, Stefan Schwartz, Nicola Gökbuget, Liliana H. Mochmann, Claudia D. Baldus
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract FAT atypical cadherin 1 (FAT1), a transmembrane protein, is frequently mutated in various cancer types and has been described as context-dependent tumor suppressor or oncogene. The FAT1 gene is mutated in 12–16% of T-cell acute leukemia (T
Externí odkaz:
https://doaj.org/article/73aaef34737c42fdadc2a0d1ed2b4094
Autor:
Mahdi Golkaram, Fengshen Kuo, Sounak Gupta, Maria I. Carlo, Michael L. Salmans, Raakhee Vijayaraghavan, Cerise Tang, Vlad Makarov, Phillip Rappold, Kyle A. Blum, Chen Zhao, Rami Mehio, Shile Zhang, Jim Godsey, Traci Pawlowski, Renzo G. DiNatale, Luc G. T. Morris, Jeremy Durack, Paul Russo, Ritesh R. Kotecha, Jonathan Coleman, Ying-Bei Chen, Victor E. Reuter, Robert J. Motzer, Martin H. Voss, Li Liu, Ed Reznik, Timothy A. Chan, A. Ari Hakimi
Publikováno v:
Genome Medicine, Vol 14, Iss 1, Pp 1-20 (2022)
Abstract Background Intratumoral heterogeneity (ITH) is a hallmark of clear cell renal cell carcinoma (ccRCC) that reflects the trajectory of evolution and influences clinical prognosis. Here, we seek to elucidate how ITH and tumor evolution during i
Externí odkaz:
https://doaj.org/article/8c4d235ff17b43c89e96ac2ab598a085
Autor:
Moritz Knebel, Sandrina Körner, Jan Philipp Kühn, Silke Wemmert, Lukas Brust, Sigrun Smola, Mathias Wagner, Rainer M. Bohle, Luc G. T. Morris, Abhinav Pandey, Bernhard Schick, Maximilian Linxweiler
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundDue to the expanding role of immune checkpoint inhibition in the treatment of head and neck squamous cell carcinoma, understanding immunological processes in the tumor microevironment (TME) has strong translational importance. Though analyt
Externí odkaz:
https://doaj.org/article/30b9a2010e504d77a57499bbbac3ac7c
Autor:
Andrew Sangho Lee, Cristina Valero, Seong-keun Yoo, Joris L. Vos, Diego Chowell, Luc G. T. Morris
Publikováno v:
Cancers, Vol 16, Iss 1, p 175 (2023)
Head and neck squamous-cell carcinoma (HNSCC) is a disease with a generally poor prognosis; half of treated patients eventually develop recurrent and/or metastatic (R/M) disease. Patients with R/M HNSCC generally have incurable disease with a median
Externí odkaz:
https://doaj.org/article/11413649fe0a4e5eb46ebf6080447ff3
Publikováno v:
npj Precision Oncology, Vol 6, Iss 1, Pp 1-5 (2022)
Abstract The effects of cytokine and protein stabilizing carriers, such as serum albumin, on tumor response to immune checkpoint blockade (ICB) is not well understood. By examining 1714 patients across 16 cancer types, we found that high pretreatment
Externí odkaz:
https://doaj.org/article/b505c7d46c7b44c9a44fd0b4e106861d
Autor:
Matthew Rosenthal, Raymond E. Baser, Jocelyn Migliacci, Jay O. Boyle, Luc G. T. Morris, Marc A. Cohen, Bhuvanesh Singh, Jatin P. Shah, Richard J. Wong, Snehal Patel, Ian Ganly
Publikováno v:
Laryngoscope Investigative Otolaryngology, Vol 6, Iss 4, Pp 690-698 (2021)
Abstract Importance This study reports the impact of laser surgery on quality of life in patients with oral cavity lesions. Objective To compare postoperative pain and quality of life in patients treated with flexible fiberoptic CO2 laser vs electroc
Externí odkaz:
https://doaj.org/article/25ecd963c432412dae537418f0b857b5
Autor:
Cristina Valero, Mark Lee, Douglas Hoen, Kate Weiss, Daniel W. Kelly, Prasad S. Adusumilli, Paul K. Paik, George Plitas, Marc Ladanyi, Michael A. Postow, Charlotte E. Ariyan, Alexander N. Shoushtari, Vinod P. Balachandran, A. Ari Hakimi, Aimee M. Crago, Kara C. Long Roche, J. Joshua Smith, Ian Ganly, Richard J. Wong, Snehal G. Patel, Jatin P. Shah, Nancy Y. Lee, Nadeem Riaz, Jingming Wang, Ahmet Zehir, Michael F. Berger, Timothy A. Chan, Venkatraman E. Seshan, Luc G. T. Morris
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
There is an unmet clinical need for simple, accessible biomarkers to select patients who are more likely to respond to immune checkpoint therapy. Here the authors show that a lower neutrophil-to-lymphocyte ratio is associated with better overall and
Externí odkaz:
https://doaj.org/article/dd218269962540ee8add1e4fa781b7e2
Autor:
Maximilian Linxweiler, Lukas Pillong, Dragan Kopanja, Jan P. Kühn, Stefan Wagenpfeil, Julia C. Radosa, Jingming Wang, Luc G. T. Morris, Basel Al Kadah, Florian Bochen, Sandrina Körner, Bernhard Schick
Publikováno v:
Laryngoscope Investigative Otolaryngology, Vol 5, Iss 4, Pp 621-629 (2020)
Abstract Objective Endoscopic sinus surgery represents the gold standard for surgical treatment of chronic sinus diseases. Thereby, navigation systems can be of distinct use. In our study, we tested the recently developed KARL STORZ NAV1 SinusTracker
Externí odkaz:
https://doaj.org/article/22728133fa86494aa5607843a9e4bf1c
Publikováno v:
Laryngoscope Investigative Otolaryngology, Vol 5, Iss 1, Pp 175-182 (2020)
Abstract Over the past 30 years in the United States, increasing identification of small thyroid nodules has led to a dramatic rise in the detection of small thyroid cancers, many of which are unlikely to progress to overt clinical disease. Because a
Externí odkaz:
https://doaj.org/article/c81130aa6ba74008a7270f8e18ceb120