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Autor:
Félix Goulet, Nacera Mellal, Liangfu Chen, Mark S Watkins, Elaine Debien, David F. Adams, Roberta A. Thomas, Wei Shi, Kendall S. Frazier, Erding Hu, Luc Durette, Josée Laliberté
Publikováno v:
Toxicologic Pathology. 48:362-378
Daprodustat (GSK1278863) is a hypoxia-inducible factor (HIF)-prolyl hydroxylase (PHD) inhibitor in development for treatment of anemia of chronic kidney disease. Daprodustat’s biological activity simulates components of the natural response to hypo