Dietary canolol protects the heart against the deleterious effects induced by the association of rapeseed oil, vitamin E and coenzyme Q10 in the context of a high-fat diet

Autor: Thibault Leger, Isabelle Hininger-Favier, Frédéric Capel, Alain Geloen, Jean-Paul Rigaudière, Chrystèle Jouve, Elodie Pitois, Gaelle Pineau, Carole Vaysse, Jean-Michel Chardigny, Marie-Caroline Michalski, Corinne Malpuech-Brugère, Luc Demaison

Publikováno v: Nutrition & Metabolism, Vol 15, Iss 1, Pp 1-14 (2018)

Abstract Background Obesity progressively leads to cardiac failure. Omega-3 polyunsaturated fatty acids (PUFA) have been shown to have cardio-protective effects in numerous pathological situations. It is not known whether rapeseed oil, which contains

Externí odkaz: https://doaj.org/article/6cfe691d14ff48149b6a446902e52ea2

EPA Is Cardioprotective in Male Rats Subjected to Sepsis, but ALA is Not Beneficial

Autor: Thibault Leger, Chrystèle Jouve, Isabelle Hininger-Favier, Jean-Paul Rigaudiere, Frédéric Capel, Vincent Sapin, Clarisse Moreau, Alice Charrier, Luc Demaison

Publikováno v: Antioxidants, Vol 9, Iss 5, p 371 (2020)

It has been proven that dietary eicosapentaenoic acid (C20:5 n-3 or EPA) protects the heart against the deleterious effects of sepsis in female rats. We do not know if this is the case for male rodents. In this case, the efficiency of other n-3 polyu

Externí odkaz: https://doaj.org/article/2056677ac18949f1a1c98b72c6a96a31

A chronic low-dose magnesium L-lactate administration has a beneficial effect on the myocardium and the skeletal muscles

Autor: Isabelle Hininger-Favier, Chrystèle Jouve, Damien Bouvier, Jean-Paul Rigaudière, Véronique Patrac, Stéphane Walrand, Luc Demaison, Hervé Dubouchaud, Marlène Magalhaes Pinto

Publikováno v: Journal of Physiology and Biochemistry
Journal of Physiology and Biochemistry, In press, Online ahead of print, ⟨10.1007/s13105-021-00827-8⟩
Journal of Physiology and Biochemistry, Springer Verlag (Germany), In press, Online ahead of print, ⟨10.1007/s13105-021-00827-8⟩

International audience; The purpose of this study was to determine whether magnesium L-lactate is responsible for having a beneficial effect on the myocardium and the skeletal muscles and how this substrate acts at the molecular level. Twenty seven y

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e98c0494de3277dccf751854116c873
https://hal.science/hal-03311529

A procedure to extract functional isolated mitochondria from small-sized human atrial samples. Application to obesity with a partial characterisation of the organelles

Autor: Kasra Azarnoush, Valerie Batel, Luc Demaison, Bruno Miguel, Véronique Patrac, Chrystèle Jouve, Vincent Sapin, Damien Bouvier, Thibault Leger

Publikováno v: Free Radical Biology and Medicine
Free Radical Biology and Medicine, 2020, 153, pp.71-79. ⟨10.1016/j.freeradbiomed.2020.04.006⟩
Free Radical Biology and Medicine, Elsevier, 2020, 153, pp.71-79. ⟨10.1016/j.freeradbiomed.2020.04.006⟩

International audience; Evaluating the activity of cardiac mitochondria is probably the best way to estimate early cellular damage in chronic pathology. Early diagnosis allows rapid therapeutic intervention thus increasing patient survival rate in a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bc9633737906f5eda9a20dda0756ae4
https://hal.inrae.fr/hal-02623749

About the controversies of the cardioprotective effect of n-3 polyunsaturated fatty acids (PUFAs) between animal studies and clinical meta-analyses: a review with several strategies to enhance the beneficial effects of n-3 PUFAs

Autor: Thibault Leger, Kasra Azarnoush, Luc Demaison, Catherine Vergely, Luc Rochette

Publikováno v: Journal of Physiology and Biochemistry
Journal of Physiology and Biochemistry, Springer Verlag (Germany), 2019, Epub ahead of print, ⟨10.1007/s13105-019-00670-y⟩
Journal of Physiology and Biochemistry, Springer Verlag (Germany), 2019, 75 (3), pp.241-251. ⟨10.1007/s13105-019-00670-y⟩
Journal of Physiology and Biochemistry, Springer Verlag (Germany), 2019, Epub ahead of print (3), ⟨10.1007/s13105-019-00670-y⟩
Journal of Physiology and Biochemistry, 2019, Epub ahead of print (3), ⟨10.1007/s13105-019-00670-y⟩

Several meta-analyses describing the effect of n-3 polyunsaturated fatty acids on the survival rate of the victims of an acute coronary event do not clearly support a beneficial impact of these fatty acids. Yet, animal studies consistently show n-3 P

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fd43b709bdb5448c5368ea5318336b3
https://hal.archives-ouvertes.fr/hal-02059787