Zobrazeno 1 - 10
of 88
pro vyhledávání: '"Luc Bijnens"'
Publikováno v:
PLoS ONE, Vol 15, Iss 4, p e0224909 (2020)
Sequence count data are commonly modelled using the negative binomial (NB) distribution. Several empirical studies, however, have demonstrated that methods based on the NB-assumption do not always succeed in controlling the false discovery rate (FDR)
Externí odkaz:
https://doaj.org/article/4c2341a075444a0d937155230ec257ff
Autor:
Jelle Praet, Nikolay V. Manyakov, Leacky Muchene, Zhenhua Mai, Vasilis Terzopoulos, Steve de Backer, An Torremans, Pieter-Jan Guns, Tom Van De Casteele, Astrid Bottelbergs, Bianca Van Broeck, Jan Sijbers, Dirk Smeets, Ziv Shkedy, Luc Bijnens, Darrel J. Pemberton, Mark E. Schmidt, Annemie Van der Linden, Marleen Verhoye
Publikováno v:
Alzheimer’s Research & Therapy, Vol 10, Iss 1, Pp 1-16 (2018)
Abstract Background Alzheimer’s disease (AD) is a progressive neurodegenerative disorder and the most common cause of dementia in the elderly population. In this study, we used the APP/PS1 transgenic mouse model to explore the feasibility of using
Externí odkaz:
https://doaj.org/article/2e0e17af4d50440b83a9140322f6cfeb
Autor:
Victoria E. Ruiz, Thomas Battaglia, Zachary D. Kurtz, Luc Bijnens, Amy Ou, Isak Engstrand, Xuhui Zheng, Tadasu Iizumi, Briana J. Mullins, Christian L. Müller, Ken Cadwell, Richard Bonneau, Guillermo I. Perez-Perez, Martin J. Blaser
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
High or multiple doses of macrolide antibiotics, when given early in life, can perturb the metabolic and immunological development of lab mice. Here, Ruiz et al. show that even a single macrolide course, given early in life, leads to long-lasting cha
Externí odkaz:
https://doaj.org/article/d4b11426675d407594f768ad99b19727
Publikováno v:
PLoS ONE, Vol 14, Iss 2, p e0205474 (2019)
Explorative visualization techniques provide a first summary of microbiome read count datasets through dimension reduction. A plethora of dimension reduction methods exists, but many of them focus primarily on sample ordination, failing to elucidate
Externí odkaz:
https://doaj.org/article/4b43f87613ed45028f0bcc19ad087993
Autor:
Bie Verbist, Annelies Tourny, Olivier Thas, Kathy Mutambanengwe, Luc Bijnens, Stijn Hawinkel, Maxim Nazarov
Publikováno v:
Pharmaceutical Statistics. 21:345-360
Combination therapies are increasingly adopted as the standard of care for various diseases to improve treatment response, minimise the development of resistance and/or minimise adverse events. Therefore, synergistic combinations are screened early i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b1ef906f5411694bf320fbf4079a6c6
https://doi.org/10.1002/pst.2173
https://doi.org/10.1002/pst.2173
Many methods exist for controlling or estimating the false discovery rate (FDR), which is the mean of the false discovery proportion (FDP). However, in the presence of correlation between the test statistics, the FDP may show considerable variation b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::706be6f026a08a581836f441b46abf1b
https://doi.org/10.21203/rs.3.rs-1760657/v1
https://doi.org/10.21203/rs.3.rs-1760657/v1
Publikováno v:
NAR GENOMICS AND BIOINFORMATICS
NAR Genomics and Bioinformatics
NAR Genomics and Bioinformatics
High-throughput sequencing technologies allow easy characterization of the human microbiome, but the statistical methods to analyze microbiome data are still in their infancy. Differential abundance methods aim at detecting associations between the a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccb60df0085cb8ca787c5d5072c11243
http://hdl.handle.net/1942/33741
http://hdl.handle.net/1942/33741
Autor:
Isak Engstrand, Richard Bonneau, Amy Ou, Xuhui Zheng, Ken Cadwell, Victoria E. Ruiz, Briana J. Mullins, Guillermo I. Perez-Perez, Christian L. Müller, Martin J. Blaser, Tadasu Iizumi, Zachary D. Kurtz, Thomas Battaglia, Luc Bijnens
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Nature Communications
Nature Communications
Broad-spectrum antibiotics are frequently prescribed to children. Early childhood represents a dynamic period for the intestinal microbial ecosystem, which is readily shaped by environmental cues; antibiotic-induced disruption of this sensitive commu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba4f4f6fd32d9a59fa2d0c348a4caa5a
http://link.springer.com/article/10.1038/s41467-017-00531-6
http://link.springer.com/article/10.1038/s41467-017-00531-6
Publikováno v:
Briefings in Bioinformatics. 20:210-221
High-throughput sequencing technologies allow easy characterization of the human microbiome, but the statistical methods to analyze microbiome data are still in their infancy. Differential abundance methods aim at detecting associations between the a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f166e60edce7790eea964139aa86d2b
https://doi.org/10.1093/bib/bbx104
https://doi.org/10.1093/bib/bbx104
Autor:
Rudradev Sengupta, Przemyslaw Biecek, Ziv Shkedy, Nolen Joy Perualila, Luc Bijnens, Geert Molenberghs
Identification of genomic biomarkers is an important area of research in the context of drug discovery experiments. These experiments typically consist of several high dimensional datasets that contain information about a set of drugs (compounds) und
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb41cb3e9c9ae5559895cb96a08d4e73
https://lirias.kuleuven.be/handle/123456789/647490
https://lirias.kuleuven.be/handle/123456789/647490