Zobrazeno 1 - 10
of 129
pro vyhledávání: '"Lucília Saraiva"'
Autor:
Joana Moreira, Joana B. Loureiro, Danilo Correia, Andreia Palmeira, Madalena M. Pinto, Lucília Saraiva, Honorina Cidade
Publikováno v:
Pharmaceuticals, Vol 16, Iss 10, p 1354 (2023)
We previously reported that chalcone CM-M345 (1) and diarylpentanoid BP-C4 (2) induced p53-dependent growth inhibitory activity in human cancer cells. Herein, CM-M345 (1) and BP-C4 (2) analogues were designed and synthesized in order to obtain more p
Externí odkaz:
https://doaj.org/article/8786cacc1ddf46e7a76db44d185ae506
Autor:
Joana Moreira, Patrícia M. A. Silva, Matilde Barros, Lucília Saraiva, Madalena Pinto, Hassan Bousbaa, Honorina Cidade
Publikováno v:
Pharmaceuticals, Vol 16, Iss 6, p 879 (2023)
In this work, the design and synthesis of a new chalcone-trimethoxycinnamide hybrid (7) based on the combination of subunits of two promising antiproliferative compounds (CM-M345 (1) and BP-M345 (2)), previously obtained by our research group, are re
Externí odkaz:
https://doaj.org/article/4c6fd94802ad40ec8a789c435befe7c5
Autor:
Valentina Barcherini, Joana B. Loureiro, Ana Sena, Catarina Madeira, Paula Leandro, Lucília Saraiva, Alexandra M. M. Antunes, Maria M. M. Santos
Publikováno v:
Pharmaceuticals, Vol 16, Iss 2, p 146 (2023)
For the first time, the pharmacokinetic (PK) profile of tryptophanol-derived isoindolinones, previously reported as p53 activators, was investigated. From the metabolites’ identification, performed by liquid chromatography coupled to high resolutio
Externí odkaz:
https://doaj.org/article/fa47b43040ba456aa93ee7267419c89b
Autor:
Daniela Pereira, Raquel T. Lima, Andreia Palmeira, Hugo Seca, Joana Soares, Sara Gomes, Liliana Raimundo, Claudia Maciel, Madalena Pinto, Emília Sousa, M. Helena Vasconcelos, Lucília Saraiva, Honorina Cidade
Publikováno v:
Arabian Journal of Chemistry, Vol 12, Iss 8, Pp 4150-4161 (2019)
The virtual screening of a library of chalcone derivatives led us to the identification of potential new MDM2 ligands. The chalcones with the best docking scores obeying the Lipinski rule of five were subsequently prepared by base-catalyzed aldol rea
Externí odkaz:
https://doaj.org/article/a522eab0f78a4334ad2466604a9f59e2
Autor:
João L. P. Ribeiro, Joana B. Loureiro, Susana M. M. Lopes, Lucília Saraiva, Teresa M. V. D. Pinho e Melo
Publikováno v:
Pharmaceuticals, Vol 15, Iss 12, p 1510 (2022)
Herein, the synthesis and anticancer activity evaluation of a series of novel β-carbolines is reported. The reactivity of nitrosoalkenes towards indole was explored for the synthesis of novel tryptophan analogs where the carboxylic acid was replaced
Externí odkaz:
https://doaj.org/article/1e094b4492a8459c93d843ea0c2c1c95
Autor:
Shirley A. R. Sancha, Adriana V. Gomes, Joana B. Loureiro, Lucília Saraiva, Maria José U. Ferreira
Publikováno v:
Molecules, Vol 27, Iss 18, p 5759 (2022)
Aiming to find Amaryllidaceae alkaloids against breast cancer, including the highly aggressive triple-negative breast cancer, the phytochemical study of Pancratium maritimum was carried out. Several Amaryllidaceae-type alkaloids, bearing scaffolds of
Externí odkaz:
https://doaj.org/article/5509214646d54acb95fa884af96bd282
Autor:
Diogo Matias, Marisa Nicolai, Lucília Saraiva, Rute Pinheiro, Célia Faustino, Ana Diaz Lanza, Catarina Pinto Reis, Tijana Stankovic, Jelena Dinic, Milica Pesic, Patrícia Rijo
Publikováno v:
ACS Omega, Vol 4, Iss 5, Pp 8094-8103 (2019)
Externí odkaz:
https://doaj.org/article/0f6da2990fc7475b8390be1b325115e3
Autor:
Helena Ramos, Maria I.L. Soares, Joana Silva, Liliana Raimundo, Juliana Calheiros, Célia Gomes, Flávio Reis, Filipe A. Monteiro, Cláudia Nunes, Salette Reis, Bartolomeo Bosco, Silvano Piazza, Lucília Domingues, Petr Chlapek, Petr Vlcek, Pavel Fabian, Ana Teresa Rajado, A.T.P. Carvalho, Renata Veselska, Alberto Inga, Teresa M.V.D. Pinho e Melo, Lucília Saraiva
Publikováno v:
Cell Reports, Vol 35, Iss 2, Pp 108982- (2021)
Summary: Impairment of the p53 pathway is a critical event in cancer. Therefore, reestablishing p53 activity has become one of the most appealing anticancer therapeutic strategies. Here, we disclose the p53-activating anticancer drug (3S)-6,7-bis(hyd
Externí odkaz:
https://doaj.org/article/49516e7fa22e429b9dc9fbabff3cfc73
Publikováno v:
Molecules, Vol 26, Iss 16, p 4712 (2021)
Frutalin is a plant lectin with beneficial immunobiological action, although the access to its active form is still restricted. Moreover, there is a knowledge gap on isoform activity and glycosylation impact on its bioactivity, and recombinant produc
Externí odkaz:
https://doaj.org/article/3c8aaac81be641e19634e21d1858f27b
Publikováno v:
Molecules, Vol 26, Iss 12, p 3737 (2021)
The p53 protein is one of the most important tumor suppressors that are frequently inactivated in cancer cells. This inactivation occurs either because the TP53 gene is mutated or deleted, or due to the p53 protein inhibition by endogenous negative r
Externí odkaz:
https://doaj.org/article/6b9d17e5acf149adb7d23cb2cbf99477