Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Lucía Viejo"'
Autor:
Cristóbal de los Ríos, Lucía Viejo, Victoria Jiménez Carretero, Natalia Hernández Juárez, Natália Cruz-Martins, Jesús M. Hernández-Guijo
Publikováno v:
Antioxidants, Vol 12, Iss 1, p 118 (2023)
The complex etiopathogenesis of brain injury associated with neurodegeneration has sparked a lot of studies in the last century. These clinical situations are incurable, and the currently available therapies merely act on symptoms or slow down the co
Externí odkaz:
https://doaj.org/article/b464e51711d147a3ac36ceed4683a34b
Autor:
Lucía Viejo, Marcos Rubio-Alarcón, Raquel L. Arribas, Manuel Moreno-Castro, Raquel Pérez-Marín, María Braun-Cornejo, Martín Estrada-Valencia, Cristóbal de los Ríos
Publikováno v:
Molecules, Vol 26, Iss 15, p 4473 (2021)
In excitable cells, mitochondria play a key role in the regulation of the cytosolic Ca2+ levels. A dysregulation of the mitochondrial Ca2+ buffering machinery derives in serious pathologies, where neurodegenerative diseases highlight. Since the mitoc
Externí odkaz:
https://doaj.org/article/9df0f4b8e4fb4447858d66485f9b2489
Autor:
Raquel L. Arribas, Lucía Viejo, Isaac Bravo, Minerva Martínez, Eva Ramos, Alejandro Romero, Eva M. García-Frutos, Veerle Janssens, Carmen Montiel, Cristóbal de los Ríos
Publikováno v:
European Journal of Medicinal Chemistry. 251:115245
La proteína fosfatasa 2A (PP2A) es una importante Ser/Thr fosfatasa que participa en la regulación de múltiples procesos celulares. Esto implica que cualquier actividad deficiente de PP2A es responsable de graves patologías graves. Por ejemplo, u
Publikováno v:
International Journal of Biological Macromolecules. 234:123765
Autor:
Raquel Pérez-Marín, María Braun-Cornejo, Manuel Moreno-Castro, Cristóbal de los Ríos, Raquel L Arribas, Marcos Rubio-Alarcón, Martín Estrada-Valencia, Lucía Viejo
Publikováno v:
Molecules
Volume 26
Issue 15
Molecules, Vol 26, Iss 4473, p 4473 (2021)
Volume 26
Issue 15
Molecules, Vol 26, Iss 4473, p 4473 (2021)
In excitable cells, mitochondria play a key role in the regulation of the cytosolic Ca2+ levels. A dysregulation of the mitochondrial Ca2+ buffering machinery derives in serious pathologies, where neurodegenerative diseases highlight. Since the mitoc
Autor:
Lucía Viejo, Cristóbal de los Ríos, Arzobispo Morcillo, . Madrid, Spain., Diego de León, . Madrid, Spain., Raquel L Arribas
Publikováno v:
IBJ Plus.
Autor:
Vendula Hepnarova, Kamil Musilek, Aurélie Baguet, Daniel Jun, José Marco-Contelles, Lhassane Ismaili, Emmanuel Haffen, Tomas Kucera, Jan Korabecny, Jana Janockova, Angela De Simone, Eva M. García-Frutos, Vincenza Andrisano, Manuela Bartolini, B. Refouvelet, Lucía Viejo, Cristóbal de los Ríos, Adeline Etievant, Ondrej Soukup, Rudolf Andrys, Julie Monnin, Raquel L Arribas
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
Multitarget-directed ligands (MTDLs) are considered a promising therapeutic strategy to address the multifactorial nature of Alzheimer's disease (AD). Novel MTDLs have been designed as inhibitors of human acetylcholinesterases/butyrylcholinesterases,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2e6fe64522ccbd8b7235529a49bc67a
http://hdl.handle.net/10261/260260
http://hdl.handle.net/10261/260260
Autor:
Lucía Viejo, María Isabel Rodríguez-Franco, Elies Molins, Daniel J. V. A. dos Santos, Lídia Gonçalves, Maria M. M. Santos, Clara Herrera-Arozamena, Cristóbal de los Ríos, Margarida Espadinha, Ricardo M R M Lopes
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
N-Methyl-D-aspartate receptors (NMDARs) are crucial for the normal function of the central nervous system (CNS), and fundamental in memory and learning-related processes. The overactivation of these receptors is associated with numerous neurodegenera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a397ed2a33305f849048690268adb758
http://hdl.handle.net/10261/219127
http://hdl.handle.net/10261/219127
Publikováno v:
Bioorganic & Medicinal Chemistry. 26:2551-2560
Following the premises of the multitarget-directed ligands approach for the drug RD nevertheless that substitution provoked loss of viability at 100-fold higher concentrations (10 μM), what discards them for a deeper pharmacological study. Overall,
Autor:
Bradley T. Hyman, Ayush Noori, Alberto Serrano-Pozo, Sudeshna Das, Emily Merrill, Lucía Viejo
Publikováno v:
Neuropathology and applied neurobiology
Aims: Reactive astrocytes in Alzheimer’s disease (AD) have traditionally been demonstrated by increased glial fibrillary acidic protein (GFAP) immunoreactivity; however, astrocyte reaction is a complex and heterogeneous phenomenon involving multipl