Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Lucía Vázquez-Sirvent"'
Autor:
Carlos García-Crespo, Lucía Vázquez-Sirvent, Pilar Somovilla, María Eugenia Soria, Isabel Gallego, Ana Isabel de Ávila, Brenda Martínez-González, Antoni Durán-Pastor, Esteban Domingo, Celia Perales
Publikováno v:
Frontiers in Microbiology, Vol 13 (2022)
We report a quantification of the decrease of effectiveness of antiviral agents directed to hepatitis C virus, when the agents are added during an ongoing infection in cell culture vs. when they are added at the beginning of the infection. Major dete
Externí odkaz:
https://doaj.org/article/73c6d82bbe8845b18dff3ceda6ce6cbc
Autor:
Brenda Martínez-González, Lucía Vázquez-Sirvent, María E. Soria, Pablo Mínguez, Llanos Salar-Vidal, Carlos García-Crespo, Isabel Gallego, Ana I. de Ávila, Carlos Llorens, Beatriz Soriano, Ricardo Ramos-Ruiz, Jaime Esteban, Ricardo Fernandez-Roblas, Ignacio Gadea, Carmen Ayuso, Javier Ruíz-Hornillos, Concepción Pérez-Jorge, Esteban Domingo, Celia Perales
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 9 (2022)
Replication of SARS-CoV-2 in the human population is defined by distributions of mutants that are present at different frequencies within the infected host and can be detected by ultra-deep sequencing techniques. In this study, we examined the SARS-C
Externí odkaz:
https://doaj.org/article/a4878f2c6b334c20baf2fe61091dfbe2
SARS-CoV-2 Point Mutation and Deletion Spectra and Their Association with Different Disease Outcomes
Autor:
Brenda Martínez-González, María Eugenia Soria, Lucía Vázquez-Sirvent, Cristina Ferrer-Orta, Rebeca Lobo-Vega, Pablo Mínguez, Lorena de la Fuente, Carlos Llorens, Beatriz Soriano, Ricardo Ramos, Marta Cortón, Rosario López-Rodríguez, Carlos García-Crespo, Isabel Gallego, Ana Isabel de Ávila, Jordi Gómez, Luis Enjuanes, Llanos Salar-Vidal, Jaime Esteban, Ricardo Fernandez-Roblas, Ignacio Gadea, Carmen Ayuso, Javier Ruíz-Hornillos, Nuria Verdaguer, Esteban Domingo, Celia Perales
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 2 (2022)
ABSTRACT Mutant spectra of RNA viruses are important to understand viral pathogenesis and response to selective pressures. There is a need to characterize the complexity of mutant spectra in coronaviruses sampled from infected patients. In particular
Externí odkaz:
https://doaj.org/article/6d9736d4a3d14394be76e5f75a5176ca
Autor:
Soledad Delgado, Celia Perales, Carlos García-Crespo, María Eugenia Soria, Isabel Gallego, Ana Isabel de Ávila, Brenda Martínez-González, Lucía Vázquez-Sirvent, Cecilio López-Galíndez, Federico Morán, Esteban Domingo
Publikováno v:
Microbiology Spectrum, Vol 9, Iss 3 (2021)
ABSTRACT RNA viruses replicate as complex mutant spectra termed viral quasispecies. The frequency of each individual genome in a mutant spectrum depends on its rate of generation and its relative fitness in the replicating population ensemble. The ad
Externí odkaz:
https://doaj.org/article/041d5980a232449789212264732757dd
Autor:
Brenda Martínez-González, María Eugenia Soria, Lucía Vázquez-Sirvent, Cristina Ferrer-Orta, Rebeca Lobo-Vega, Pablo Mínguez, Lorena de la Fuente, Carlos Llorens, Beatriz Soriano, Ricardo Ramos-Ruíz, Marta Cortón, Rosario López-Rodríguez, Carlos García-Crespo, Pilar Somovilla, Antoni Durán-Pastor, Isabel Gallego, Ana Isabel de Ávila, Soledad Delgado, Federico Morán, Cecilio López-Galíndez, Jordi Gómez, Luis Enjuanes, Llanos Salar-Vidal, Mario Esteban-Muñoz, Jaime Esteban, Ricardo Fernández-Roblas, Ignacio Gadea, Carmen Ayuso, Javier Ruíz-Hornillos, Nuria Verdaguer, Esteban Domingo, Celia Perales
Publikováno v:
Pathogens, Vol 11, Iss 6, p 662 (2022)
Populations of RNA viruses are composed of complex and dynamic mixtures of variant genomes that are termed mutant spectra or mutant clouds. This applies also to SARS-CoV-2, and mutations that are detected at low frequency in an infected individual ca
Externí odkaz:
https://doaj.org/article/1a2a6aef651b4189a3f7cf754f253bd4
Autor:
Carlos García-Crespo, Isabel Gallego, María Eugenia Soria, Ana Isabel de Ávila, Brenda Martínez-González, Lucía Vázquez-Sirvent, Rebeca Lobo-Vega, Elena Moreno, Jordi Gómez, Carlos Briones, Josep Gregori, Josep Quer, Esteban Domingo, Celia Perales
Publikováno v:
Viruses, Vol 13, Iss 4, p 616 (2021)
Replication of RNA viruses is characterized by exploration of sequence space which facilitates their adaptation to changing environments. It is generally accepted that such exploration takes place mainly in response to positive selection, and that fu
Externí odkaz:
https://doaj.org/article/814414a9f9ba4609b11b9c04f46cf904
Autor:
Carlos García-Crespo, Federico Morán, Soledad Delgado, Cecilio López-Galíndez, Brenda Martínez-González, Celia Perales, Lucía Vázquez-Sirvent, María Eugenia Soria, Ana Isabel de Ávila, Esteban Domingo, Isabel Gallego
Publikováno v:
Microbiology Spectrum, Vol 9, Iss 3 (2021)
Microbiology Spectrum
Microbiology Spectrum
RNA viruses replicate as complex mutant spectra termed viral quasispecies. The frequency of each individual genome in a mutant spectrum depends on its rate of generation and its relative fitness in the replicating population ensemble. The advent of d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78759852fcb4f834c64133826da134ae
https://journals.asm.org/doi/10.1128/Spectrum.01459-21
https://journals.asm.org/doi/10.1128/Spectrum.01459-21
Autor:
Carlos García-Crespo, Lucía Vázquez-Sirvent, Maria Eugenia Soria, Isabel Gallego, Ana Isabel de Ávila, Brenda Martínez-González, Esteban Domingo, Celia Perales
Publikováno v:
Journal of Hepatology. 77:S589-S590
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8268423e2f6d3dc1f4e23a93cfde8c17
https://doi.org/10.1016/s0168-8278(22)01497-0
https://doi.org/10.1016/s0168-8278(22)01497-0
Autor:
Isabel Gallego, Brenda Martínez-González, de Ávila Ai, Celia Perales, Federico Morán, Soledad Delgado, Lucía Vázquez-Sirvent, Esteban Domingo, María Eugenia Soria, Cecilio López-Galíndez, Carlos García-Crespo
Fitness landscapes reflect the adaptive potential of viruses. There is no information on how fitness peaks evolve when a virus replicates extensively in a controlled cell culture environment. Here we report the construction of Self-Organized Maps (SO
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c512fcf7bd0bbb7007c2179aa02ffc1c
https://doi.org/10.1101/2021.04.22.441053
https://doi.org/10.1101/2021.04.22.441053
Autor:
Lucía Vázquez-Sirvent, Rebeca Lobo-Vega, Brenda Martínez-González, Celia Perales, María Eugenia Soria, Josep Quer, Ana Isabel de Ávila, Carlos Briones, Esteban Domingo, Jordi Gómez, Josep Gregori, Isabel Gallego, Elena Moreno, Carlos García-Crespo
Publikováno v:
Viruses, Vol 13, Iss 616, p 616 (2021)
Viruses
Scientia
DIGITAL.INTA Repositorio Digital del Instituto Nacional de Técnica Aeroespacial
instname
Instituto Nacional de Técnica Aeroespacial (INTA)
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
Viruses
Scientia
DIGITAL.INTA Repositorio Digital del Instituto Nacional de Técnica Aeroespacial
instname
Instituto Nacional de Técnica Aeroespacial (INTA)
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
Replication of RNA viruses is characterized by exploration of sequence space which facilitates their adaptation to changing environments. It is generally accepted that such exploration takes place mainly in response to positive selection, and that fu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5d6fa0354e8b7dd06adc0751c8ec87e
https://www.mdpi.com/1999-4915/13/4/616
https://www.mdpi.com/1999-4915/13/4/616