Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Lucía F. Zacchi"'
Autor:
Christian Fercher, Lucía F. Zacchi
Publikováno v:
Frontiers in Molecular Biosciences, Vol 7 (2020)
TorsinA is a AAA+ ATPase involved in the severe neurological disease Early Onset Torsion Dystonia. Despite the impressive progress in the field in the recent years, the structural organization and function of this intriguing molecule is still not cle
Externí odkaz:
https://doaj.org/article/8bd06404701c4baaa55c66d943172d7d
Autor:
Lucía F. Zacchi, John C. Dittmar, Michael J. Mihalevic, Annette M. Shewan, Benjamin L. Schulz, Jeffrey L. Brodsky, Kara A. Bernstein
Publikováno v:
Disease Models & Mechanisms, Vol 10, Iss 9, Pp 1129-1140 (2017)
Dystonia is the third most common movement disorder, but its diagnosis and treatment remain challenging. One of the most severe types of dystonia is early-onset torsion dystonia (EOTD). The best studied and validated EOTD-associated mutation, torsinA
Externí odkaz:
https://doaj.org/article/f7ac7a235cf04b5ba2e8af83825ca350
Autor:
Máximo Lopez Medus, Gabriela E. Gomez, Lucía F. Zacchi, Paula M. Couto, Carlos A. Labriola, María S. Labanda, Rodrigo Corti Bielsa, Eugenia M. Clérico, Benjamin L. Schulz, Julio J. Caramelo
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract Nearly one third of the eukaryotic proteome traverses the secretory pathway and most of these proteins are N-glycosylated in the lumen of the endoplasmic reticulum. N-glycans fulfill multiple structural and biological functions, and are cruc
Externí odkaz:
https://doaj.org/article/acdc1970e25b4dc48e101af8943a54cb
Autor:
Lucía F, Zacchi, Benjamin L, Schulz
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2049
Glycosylation is a complex posttranslational modification that is critical for regulating the functions of diverse proteins. Analysis of protein glycosylation is made challenging by the high degree of heterogeneity in both glycan occupancy and struct
Autor:
Lucia F. Zacchi, Dinora Roche-Recinos, Cassandra L. Pegg, Toan K. Phung, Mark Napoli, Campbell Aitken, Vanessa Sandford, Stephen M. Mahler, Yih Yean Lee, Benjamin L. Schulz, Christopher B. Howard
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-19 (2021)
Zacchi et al. attempt to bridge the gap between understanding the impact of process variables and determination of critical post-translational modifications on a highly complex glycoprotein, factor IX. They implement an LC-MS/MS approach based on dat
Externí odkaz:
https://doaj.org/article/71aba8fb8f8b4392a1a05cbdb5d2e86f
Autor:
Nadya Panagides, Lucia F. Zacchi, Mitchell J. De Souza, Rodrigo A. V. Morales, Alexander Karnowski, Mark T. Liddament, Catherine M. Owczarek, Stephen M. Mahler, Con Panousis, Martina L. Jones, Christian Fercher
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 15, p 8470 (2022)
Monoclonal antibodies (mAbs) are one of the most successful and versatile protein-based pharmaceutical products used to treat multiple pathological conditions. The remarkable specificity of mAbs and their affinity for biological targets has led to th
Externí odkaz:
https://doaj.org/article/74b36690ce38488ea6dcf46f2c356c98