Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Lucía Boiani"'
Autor:
Mercedes González, Lucía Boiani, Lucía Piacenza, Hugo Cerecetto, Ana Denicola, Mariana Boiani, Paola Hernández
Publikováno v:
Biochemical Pharmacology. 79:1736-1745
Chagas disease is caused by the trypanosomatid parasite Trypanosoma cruzi and threatens millions of lives in South America. As other neglected diseases there is almost no research and development effort by the pharmaceutical industry and the treatmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37daa53566aaeec45d06cb8652dc8c98
https://doi.org/10.1016/j.bcp.2010.02.009
https://doi.org/10.1016/j.bcp.2010.02.009
Autor:
Lucía Boiani, Mercedes González, Catalina Carrasco-Pozo, Juan Diego Maya, Jorge Rodríguez, Hernán Speisky Cosoy, Hugo Cerecetto, María Laura Lavaggi, Claudio Olea-Azar, Vicente J. Arán
Publikováno v:
BIOORGANIC & MEDICINAL CHEMISTRY
Artículos CONICYT
CONICYT Chile
instacron:CONICYT
Artículos CONICYT
CONICYT Chile
instacron:CONICYT
New 5-nitroindazole derivatives were developed and their antichagasic properties studied. Eight compounds (14–18, 20, 26 and 28) displayed remarkable in vitro activities against Trypanosoma cruzi (T. cruzi). Its unspecific cytotoxicity against macr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44001820cf38c50ef004db3b86ad3d5f
https://doi.org/10.1016/j.bmc.2009.10.030
https://doi.org/10.1016/j.bmc.2009.10.030
Autor:
Mercedes González, Agustina Chidichimo, Alicia Merlino, Paola Hernández, Mariana Boiani, Juan José Cazzulo, Lucía Boiani, Hugo Cerecetto
Publikováno v:
European Journal of Medicinal Chemistry. 44:4426-4433
Exploring the influence of different substitution patterns of 2H-benzimidazole 1,3-dioxide derivatives (BzNO) we prepared fifteen new derivatives. Initially the BzNO were tested against Trypanosoma cruzi Tulahuen 2 strain epimastigote form rendering
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::250d63c275be55cf2c466f90ea04f2c0
https://doi.org/10.1016/j.ejmech.2009.06.014
https://doi.org/10.1016/j.ejmech.2009.06.014
Autor:
Hugo Cerecetto, Ninfa Vera de Bilbao, Lucía Boiani, Susana Torres de Ortiz, J. Antonio Morello, Vicente J. Arán, Alejandra Gerpe, Elva Serna, Hector Nakayama, Luis Sanabria, Gloria Yaluff, Antonieta Rojas de Arias, Mercedes González, Juan Diego Maya
Publikováno v:
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Artículos CONICYT
CONICYT Chile
instacron:CONICYT
Artículos CONICYT
CONICYT Chile
instacron:CONICYT
Previously, we have identified a series of 5-nitroindazoles with good antiprotozoal activities, against Trypanosoma cruzi epimastigotes and Trichomonas vaginalis. Most of them have shown very low unspecific toxicity on macrophage cell lines. In the p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34c2389a396502f34d579fba1d353b0f
https://doi.org/10.1016/j.ejmech.2008.06.024
https://doi.org/10.1016/j.ejmech.2008.06.024
Autor:
Mercedes González, M. Cristina Caterina, Isabel A. Perillo, Alejandra Salerno, Lucía Boiani, Hugo Cerecetto, Horacio Pezaroglo
Publikováno v:
Bioorganic & Medicinal Chemistry. 16:2226-2234
Imidazolidine derivatives were studied as anti-Trypanosoma cruzi agents. Imidazolines can be considered as ethylenediamine/carbonyl precursors and therefore interfere with the biosynthesis of polyamines into the parasite. Some of the derivatives were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8afc7c8ed38100e27b8319ce49663665
https://doi.org/10.1016/j.bmc.2007.11.077
https://doi.org/10.1016/j.bmc.2007.11.077
Autor:
Ana I. Gómez de Castro, Mercedes González, Gabriela Aguirre, Ana M. Ferreira, Lucía Boiani, Mariana Boiani, Alicia Merlino, Williams Porcal, Hugo Cerecetto, Rossanna Di Maio, Paola Hernández
Publikováno v:
Bioorganic & Medicinal Chemistry. 15:2768-2781
In vitro growth inhibitory activity of 21 new 5-ethenylbenzofuroxan derivatives against the protozoan parasite Trypanosoma cruzi, the causative agent of American trypanosomiasis, was studied. The designed compounds possess the previously described ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fa707db83987a36396fb8499604ffea
https://doi.org/10.1016/j.bmc.2007.01.009
https://doi.org/10.1016/j.bmc.2007.01.009
Autor:
Williams Porcal, Gabriela Aguirre, Mercedes González, Verónica Tórtora, Rossanna Di Maio, Matías N. Möller, Leonor Thomson, Hugo Cerecetto, Lucía Boiani, Ana Denicola
Publikováno v:
Bioorganic & Medicinal Chemistry. 13:6324-6335
The results of a study on the use of Hansch’s series design, cluster methodology, for the generation of new benzo[1,2- c ]1,2,5-oxadiazole N -oxide derivatives as antitrypanosomal compounds are described. In vitro activity of these compounds was te
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e57d25d003d533ce5f3bc84f12a7af29
https://doi.org/10.1016/j.bmc.2005.05.020
https://doi.org/10.1016/j.bmc.2005.05.020
Autor:
Ivana Urban, Fernán Agüero, Hai Yu, Agustina Chidichimo, Lucía Boiani Santurio, Juan Mucci, Carlos A. Buscaglia, Xi Chen
Publikováno v:
The Biochemical journal. 438(2)
The surface of the protozoan Trypanosoma cruzi is covered by a dense coat of mucin-type glycoconjugates, which make a pivotal contribution to parasite protection and host immune evasion. Their importance is further underscored by the presence of >100
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04a4dfb8d48ac3bd809d3599924feddf
https://pubmed.ncbi.nlm.nih.gov/21651499
https://pubmed.ncbi.nlm.nih.gov/21651499
Autor:
Enrique Torres, Maria Elena Ferreira, Beatriz Solano, Hugo Cerecetto, Mauricio Cabrera, Adela López de Cerain, Silvia Pérez-Silanes, Susana Torres, Diego Benítez, Elva Serna, Ninfa Vera de Bilbao, Gloria Yaluff, Paola Hernández, Antonio Monge, Ignacio Aldana, Elsa Moreno Moreno, Mercedes González, Rossanna Di Maio, Lucía Boiani, María Laura Lavaggi
Publikováno v:
Journal of medicinal chemistry. 54(10)
For a fourth approach of quinoxaline N,N'-dioxides as anti-trypanosomatid agents against T. cruzi and Leishmania, we found extremely active derivatives. The present study allows us to state the correct requirements for obtaining optimal in vitro anti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea2722e43657056fa1ef30ec34e7812e
https://pubmed.ncbi.nlm.nih.gov/21506600
https://pubmed.ncbi.nlm.nih.gov/21506600
Autor:
Paola Hernández, Maximiliano Sortino, Alejandra Gerpe, Hugo Cerecetto, Lucía Boiani, Mercedes González, Susana Zacchino
Publikováno v:
ChemInform. 41
The naftifine analogues are designed as potential T.cruzi membrane sterol biosynthesis inhibitors.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d5db629f55b7cb74c1a950241a7b0303
https://doi.org/10.1002/chin.201041161
https://doi.org/10.1002/chin.201041161