Výsledky vyhledávání - "Luc, Mercken"

Akademický článek

Antibody-bound β-amyloid precursor protein stimulates the production of tumor necrosis factor-α and monocyte chemoattractant protein-1 by cortical neurons

Autor: Corinne Mbebi, Jose-Luis González de Aguilar, Violaine Sée, Luc Dupuis, Nelly Frossard, Luc Mercken, Laurent Pradier, Yves Larmet, Jean-Philippe Loeffler

Publikováno v: Neurobiology of Disease, Vol 19, Iss 1, Pp 129-141 (2005)

Alzheimer's disease (AD) is an age-related neurodegenerative disorder characterized by the accumulation of extracellular depositions of fibrillar β-amyloid (Aβ), which is derived from the alternative processing of β-amyloid precursor protein (APP)

Externí odkaz: https://doaj.org/article/c50519f4e70747238489ec2ecb4593e3

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Akademický článek

Differential Screening of Mutated SOD1 Transgenic Mice Reveals Early Up-Regulation of a Fast Axonal Transport Component in Spinal Cord Motor Neurons

Autor: Luc Dupuis, Marc de Tapia, Frédérique René, Bernadette Lutz-Bucher, Jon W. Gordon, Luc Mercken, Laurent Pradier, Jean-Philippe Loeffler

Publikováno v: Neurobiology of Disease, Vol 7, Iss 4, Pp 274-285 (2000)

In the present study we analyze the molecular mechanisms underlying motor neuron degeneration in familial amyotrophic lateral sclerosis (FALS). For this, we used a transgenic mouse model expressing the Cu/Zn superoxide dismutase (SOD1) gene with a Gl

Externí odkaz: https://doaj.org/article/72d6424233ce45a2bbfcf47b3d4487ea

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Akademický článek

Mapping the APP/Presenilin (PS) Binding Domains: The Hydrophilic N-Terminus of PS2 Is Sufficient for Interaction with APP and Can Displace APP/PS1 Interaction

Autor: Laurent Pradier, Nathalie Carpentier, Laurence Delalonde, Nicole Clavel, Marie-Dominique Bock, Luc Buée, Luc Mercken, Bruno Tocqué, Christian Czech

Publikováno v: Neurobiology of Disease, Vol 6, Iss 1, Pp 43-55 (1999)

Mutations in presenilin 1 and presenilin 2 (PS1 and PS2, respectively) genes cause the large majority of familial forms of early-onset Alzheimer's disease. The physical interaction between presenilins and APP has been recently described using coimmun

Externí odkaz: https://doaj.org/article/e74a0eab420d4e09aca715f3a9c305c5

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Antibody-bound β-amyloid precursor protein stimulates the production of tumor necrosis factor-α and monocyte chemoattractant protein-1 by cortical neurons

Autor: Nelly Frossard, Luc Dupuis, Violaine Sée, Yves Larmet, Laurent Pradier, Jean-Philippe Loeffler, Jose-Luis Gonzalez de Aguilar, Luc Mercken, Corinne Mbebi

Publikováno v: Neurobiology of Disease, Vol 19, Iss 1, Pp 129-141 (2005)

Alzheimer's disease (AD) is an age-related neurodegenerative disorder characterized by the accumulation of extracellular depositions of fibrillar beta-amyloid (A beta), which is derived from the alternative processing of beta-amyloid precursor protei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d809604ee48883d68873312ac0e737c2
http://www.sciencedirect.com/science/article/pii/S0969996104002864

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Expression of human FE65 in amyloid precursor protein transgenic mice is associated with a reduction in β-amyloid load

Autor: Charles Duyckaerts, Laurent Pradier, Nathalie Touchet, Luc Mercken, Nicolas Sergeant, André Delacourte, Gunter Tremp, Dominique Santiard-Baron, Dominique Langui, Benoît Delatour, Véronique Blanchard, Brigitte Schombert, Maryse Delehedde, Marie-Françoise Paul

Publikováno v: Journal of Neurochemistry. 93:330-338

FE65 is an adaptor protein that interacts with the cytoplasmic tail of the amyloid precursor protein (APP). In cultured non-neuronal cells, the formation of the FE65-APP complex is a key element for the modulation of APP processing, signalling and be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5d10d9748debebe820bedaac9aef76df
https://doi.org/10.1111/j.1471-4159.2005.03026.x

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The Neuronal Adaptor Protein X11α Reduces Aβ Levels in the Brains of Alzheimer's APPswe Tg2576 Transgenic Mice

Autor: Stephen J. A. Shemilt, Jonathan D. Cooper, Ju-Hyun Lee, Declan M. McLoughlin, Claire L. Standen, Christopher C.J. Miller, Michael S. Perkinton, Luc Mercken, Kwok-Fai Lau

Publikováno v: Journal of Biological Chemistry. 278:47025-47029

Increased production and deposition of the 40-42-amino acid beta-amyloid peptide (Abeta) is believed to be central to the pathogenesis of Alzheimer's disease. Abeta is derived from the amyloid precursor protein (APP), but the mechanisms that regulate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::046ffb8f45fd0a7f98837bb388dc1a3b
https://doi.org/10.1074/jbc.m300503200

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A risk for early-onset Alzheimer's disease associated with the APBB1 gene (FE65) intron 13 polymorphism

Autor: Laurent Pradier, Emmanuelle Génin, Jesus Benavides, Emmanuelle Cousin, Dominique Campion, Luc Mercken, Thierry Frebourg, Didier Hannequin, Alexis Brice, Sylvain Ricard, Bruno Dubois, Jean-Francois Deleuze, C. Chansac, Sandrine Mace

Publikováno v: Neuroscience Letters. 342:5-8

Alzheimer's disease (AD) is a genetically complex neurodegenerative disorder and the leading cause of dementia of the elderly. Recently, Hu et al. suggested that a trinucleotide deletion in intron 13 of the APBB1 gene was a factor protecting against

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22b9905b2da8adeff63974fe1912a4a0
https://doi.org/10.1016/s0304-3940(03)00225-8

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Platelet-derived Growth Factor Induces the β-γ-Secretase-mediated Cleavage of Alzheimer's Amyloid Precursor Protein through a Src-Rac-dependent Pathway

Autor: Giuseppina Minopoli, Davide Gianni, Luc Mercken, Marida Bimonte, Andrea Scaloni, Fabio Talamo, Nicola Zambrano, Tommaso Russo

Publikováno v: Journal of Biological Chemistry. 278:9290-9297

The beta-amyloid peptide (Abeta) present in the senile plaques of Alzheimer's disease derives from the cleavage of a membrane protein, named APP, driven by two enzymes, known as beta- and gamma-secretases. The mechanisms regulating this cleavage are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efab142a7e10a5172b582aeefc984171
https://doi.org/10.1074/jbc.m211899200

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Amyloid Precursor Protein Family-induced Neuronal Death Is Mediated by Impairment of the Neuroprotective Calcium/Calmodulin Protein Kinase IV-dependent Signaling Pathway

Autor: Laurent Pradier, Corinne Mbebi, Violaine Sée, Ulrike Müller, Luc Mercken, Jean-Philippe Loeffler

Publikováno v: Journal of Biological Chemistry. 277:20979-20990

The aberrant metabolism of beta-amyloid precursor protein (APP) and the progressive deposition of its derived fragment beta-amyloid peptide are early and constant pathological hallmarks of Alzheimer's disease. Because APP is able to function as a cel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8107e3d8e3070e12a567e20eedeb2118
https://doi.org/10.1074/jbc.m107948200

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The caspase-derived C-terminal fragment of βAPP induces caspase-independent toxicity and triggers selective increase of Aβ42 in mammalian cells

Autor: Cristine Alves da Costa, Laurent Pradier, Luc Mercken, Cécile Dumanchin-Njock, Frédéric Checler

Publikováno v: Journal of Neurochemistry. 78:1153-1161

During its physiopathological maturation, the β-amyloid precursor protein undergoes several distinct proteolytic events by activities called secretases. In Alzheimer's disease, the main histological hallmark called senile plaque is clearly linked to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b9083cac80688777880937dda893861c
https://doi.org/10.1046/j.1471-4159.2001.00513.x

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