Zobrazeno 1 - 10
of 528
pro vyhledávání: '"Luc, Girard"'
The oncogenic role of LGR6 overexpression induced by aberrant Wnt/β‐catenin signaling in lung cancer
Autor:
Noriaki Sunaga, Kyoichi Kaira, Kimihiro Shimizu, Ichidai Tanaka, Yosuke Miura, Seshiru Nakazawa, Yoichi Ohtaki, Reika Kawabata‐Iwakawa, Mitsuo Sato, Luc Girard, John D. Minna, Takeshi Hisada
Publikováno v:
Thoracic Cancer, Vol 15, Iss 2, Pp 131-141 (2024)
Abstract Background Molecular abnormalities in the Wnt/β‐catenin pathway confer malignant phenotypes in lung cancer. Previously, we identified the association of leucine‐rich repeat‐containing G protein‐coupled receptor 6 (LGR6) with oncogen
Externí odkaz:
https://doaj.org/article/5f3ac49b46674432a77218e09361baf5
Autor:
Hoi‐Hin Kwok, Huiyu Li, Jiashuang Yang, Junyang Deng, Nerissa Chui‐Mei Lee, Timmy Wing‐Kuk Au, Alva Ko‐Yung Sit, Michael Kuan‐Yew Hsin, Stephanie Kwai‐Yee Ma, Lydia Wai‐Ting Cheung, Luc Girard, Junya Fujimoto, Ignacio Ivan Wistuba, Boning Gao, John Dorrance Minna, David Chi‐Leung Lam
Publikováno v:
Cancer Communications, Vol 43, Iss 8, Pp 951-955 (2023)
Externí odkaz:
https://doaj.org/article/c614af5c808441f3a89ca062943cc0a8
Autor:
Florian Malchers, Lucia Nogova, Martijn H.A. van Attekum, Lukas Maas, Johannes Brägelmann, Christoph Bartenhagen, Luc Girard, Graziella Bosco, Ilona Dahmen, Sebastian Michels, Clare E. Weeden, Andreas H. Scheel, Lydia Meder, Kristina Golfmann, Philipp Schuldt, Janna Siemanowski, Jan Rehker, Sabine Merkelbach-Bruse, Roopika Menon, Oliver Gautschi, Johannes M. Heuckmann, Elisabeth Brambilla, Marie-Liesse Asselin-Labat, Thorsten Persigehl, John D. Minna, Henning Walczak, Roland T. Ullrich, Matthias Fischer, Hans Christian Reinhardt, Jürgen Wolf, Reinhard Büttner, Martin Peifer, Julie George, Roman K. Thomas
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 21 (2023)
The discovery of frequent 8p11-p12 amplifications in squamous cell lung cancer (SQLC) has fueled hopes that FGFR1, located inside this amplicon, might be a therapeutic target. In a clinical trial, only 11% of patients with 8p11 amplification (detecte
Externí odkaz:
https://doaj.org/article/ef6247e9f6b84dbca5a0844486ed3d80
Autor:
Puneeth Iyengar, Aakash Y. Gandhi, Jorge Granados, Tong Guo, Arun Gupta, Jinhai Yu, Ernesto M. Llano, Faya Zhang, Ang Gao, Asha Kandathil, Dorothy Williams, Boning Gao, Luc Girard, Venkat S. Malladi, John M. Shelton, Bret M. Evers, Raquibul Hannan, Chul Ahn, John D. Minna, Rodney E. Infante
Publikováno v:
JCI Insight, Vol 8, Iss 8 (2023)
Cancer cachexia (CC), a wasting syndrome of muscle and adipose tissue resulting in weight loss, is observed in 50% of patients with solid tumors. Management of CC is limited by the absence of biomarkers and knowledge of molecules that drive its pheno
Externí odkaz:
https://doaj.org/article/6f7581b120d34f2291bd9e772c731785
Autor:
Kenneth E. Huffman, Long Shan Li, Ryan Carstens, Hyunsil Park, Luc Girard, Kimberley Avila, Shuguang Wei, Rahul Kollipara, Brenda Timmons, Jessica Sudderth, Nawal Bendris, Jiyeon Kim, Pamela Villalobos, Junya Fujimoto, Sandra Schmid, Ralph J. Deberardinis, Ignacio Wistuba, John Heymach, Ralf Kittler, Esra A. Akbay, Bruce Posner, Yuzhuo Wang, Stephen Lam, Steven A. Kliewer, David J. Mangelsdorf, John D. Minna
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
The glucocorticoid receptor (GR) is an important anti-cancer target in lymphoid cancers but has been understudied in solid tumors like lung cancer, although glucocorticoids are often given with chemotherapy regimens to mitigate side effects. Here, we
Externí odkaz:
https://doaj.org/article/12a85fec027a43f998070bed490eb234
Autor:
Ling Cai, Hongyu Liu, Fang Huang, Junya Fujimoto, Luc Girard, Jun Chen, Yongwen Li, Yu-An Zhang, Dhruba Deb, Victor Stastny, Karine Pozo, Christin S. Kuo, Gaoxiang Jia, Chendong Yang, Wei Zou, Adeeb Alomar, Kenneth Huffman, Mahboubeh Papari-Zareei, Lin Yang, Benjamin Drapkin, Esra A. Akbay, David S. Shames, Ignacio I. Wistuba, Tao Wang, Jane E. Johnson, Guanghua Xiao, Ralph J. DeBerardinis, John D. Minna, Yang Xie, Adi F. Gazdar
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
Ling Cai et al. used transcriptomic profiling data of healthy lung, patient-derived small cell lung cancer cell lines, xenografts, and primary tumors to examine a link between neuroendocrine (NE) signatures and immune gene expression. Their findings
Externí odkaz:
https://doaj.org/article/c88977f0af0c4f029def4e50d414f3bb
Autor:
Suzie K. Hight, Allison Mootz, Rahul K. Kollipara, Elizabeth McMillan, Paul Yenerall, Yoichi Otaki, Long-Shan Li, Kimberley Avila, Michael Peyton, Jaime Rodriguez-Canales, Barbara Mino, Pamela Villalobos, Luc Girard, Patrick Dospoy, Jill Larsen, Michael A. White, John V. Heymach, Ignacio I. Wistuba, Ralf Kittler, John D. Minna
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 22, Iss 8, Pp 294-310 (2020)
Using a mini-library of 1062 lentiviral shRNAs targeting 40 nuclear hormone receptors and 70 of their co-regulators, we searched for potential therapeutic targets that would be important during in vivo tumor growth using a parallel in vitro and in vi
Externí odkaz:
https://doaj.org/article/482fd373bde3424183dc0e497a6a3920
Publikováno v:
Plasma Chemistry and Plasma Processing. 43:709-736
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a48d2cbd12438821052a0254feca39b
https://doi.org/10.1007/s11090-023-10319-w
https://doi.org/10.1007/s11090-023-10319-w
Autor:
Camille Tlemsani, Lorinc Pongor, Fathi Elloumi, Luc Girard, Kenneth E. Huffman, Nitin Roper, Sudhir Varma, Augustin Luna, Vinodh N. Rajapakse, Robin Sebastian, Kurt W. Kohn, Julia Krushkal, Mirit I. Aladjem, Beverly A. Teicher, Paul S. Meltzer, William C. Reinhold, John D. Minna, Anish Thomas, Yves Pommier
Publikováno v:
Cell Reports, Vol 33, Iss 3, Pp 108296- (2020)
Summary: CellMiner-SCLC (https://discover.nci.nih.gov/SclcCellMinerCDB/) integrates drug sensitivity and genomic data, including high-resolution methylome and transcriptome from 118 patient-derived small cell lung cancer (SCLC) cell lines, providing
Externí odkaz:
https://doaj.org/article/c3a89008a1ef48f497155a5b22995bc3
Autor:
Ilgen Mender, Ryan LaRanger, Krishna Luitel, Michael Peyton, Luc Girard, Tsung-Po Lai, Kimberly Batten, Crystal Cornelius, Maithili P. Dalvi, Michael Ramirez, Wenting Du, Lani F. Wu, Steven J. Altschuler, Rolf Brekken, Elisabeth D. Martinez, John D. Minna, Woodring E. Wright, Jerry W. Shay
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 20, Iss 8, Pp 826-837 (2018)
Standard and targeted cancer therapies for late-stage cancer patients almost universally fail due to tumor heterogeneity/plasticity and intrinsic or acquired drug resistance. We used the telomerase substrate nucleoside precursor, 6-thio-2′-deoxygua
Externí odkaz:
https://doaj.org/article/4cb2a9b75e64451da5d6b5d27e43a411