Výsledky vyhledávání - "Luc, English"

Contribution de l’autophagie dans l’apprêtement d’antigènes viraux endogènes

Autor: Magali Chemali, Luc English, Michel Desjardins

Publikováno v: médecine/sciences. 25:906-909

M/S n° 11, vol. 25, novembre 2009 Xenophagie, immunite innee et immunite acquise L’autophagie designe le processus par lequel la cellule capture du materiel cytoplasmique afin de le degrader dans des lysosomes. Ce mecanisme permet notamment de rec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9de940fb7db47ceb02aac5bc67d415b7
https://doi.org/10.1051/medsci/20092511906

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Nuclear membrane-derived autophagy, a novel process that participates in the presentation of endogenous viral antigens during HSV-1 infection

Autor: Luc English, Michel Desjardins, Magali Chemali

Publikováno v: Autophagy. 5:1026-1029

Complex membrane trafficking events are involved in the regulation of antigen processing and presentation of both endogenous and exogenous antigens. While these processes were believed to involve mainly organelles along the endo/phagocytic and the bi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58233a9c1060dbf9ecb49d9a25a2b2f3
https://doi.org/10.4161/auto.5.7.9163

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The Tanami deep seismic reflection experiment: An insight into gold mineralization and Paleoproterozoic collision in the North Australian Craton

Autor: Bruce Goleby, Patrick Lyons, Luc English, Tim Smith, Leonie Jones, Musie Gebre-Mariam, David L. Huston, Leon Vandenberg, Wade Johnson, Leon Bagas, Brett M. Davies

Publikováno v: Tectonophysics. 472:169-182

Imaging of a major collision zone between the Tanami region and Aileron Province of the Arunta Orogen in Northern Australia, and recognition that several of the major gold deposits within the Tanami region are within near-surface antiformal stacks or

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2da425f38e44e32bf5f9e32349ef52f4
https://doi.org/10.1016/j.tecto.2008.05.031

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Autophagy enhances the presentation of endogenous viral antigens on MHC class I molecules during HSV-1 infection

Autor: Diane E. Alexander, David A. Leib, Magali Chemali, Annie Laplante, Diane Gingras, Roger Lippé, Michel Desjardins, Johanne Duron, Luc English, Christiane Rondeau, Christopher C. Norbury

Publikováno v: Nature Immunology. 10:480-487

Viral proteins are usually processed by the 'classical' major histocompatibility complex (MHC) class I presentation pathway. Here we showed that although macrophages infected with herpes simplex virus type 1 (HSV-1) initially stimulated CD8(+) T cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2845e14a5268cf1633b3de526e4544a0
https://doi.org/10.1038/ni.1720

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The Phagosomal Proteome in Interferon-γ-Activated Macrophages

Autor: Mathieu Courcelles, Sébastien Lemieux, Matthias Trost, Luc English, Pierre Thibault, Michel Desjardins

Publikováno v: Immunity. 30(1):143-154

The ability of macrophages to clear pathogens and elicit a sustained immune response is regulated by various cytokines, including interferon-gamma (IFN-gamma). To investigate the molecular mechanisms by which IFN-gamma modulates phagosome functions,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c71a71c10525065bb8874e2f526b6708

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An example of a Palaeoproterozoic back-arc basin: Petrology and geochemistry of the ca. 1864Ma Stubbins Formation as an aid towards an improved understanding of the Granites–Tanami Orogen, Western Australia

Autor: J.A.C. Anderson, David L. Huston, Luc English, David Maidment, Leon Bagas, Frank P. Bierlein

Publikováno v: Precambrian Research. 166:168-184

The Palaeoproterozoic Stubbins Formation is a newly defined succession of turbiditic and pelagic sedimentary rocks interbedded with volcanic and abundant dolerite sills. Based on preliminary SHRIMP U–Pb data from various parts of the Stubbins Forma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2bcdc788cafc38b56173067a3d41a5b8
https://doi.org/10.1016/j.precamres.2007.06.025

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RUN and FYVE domain-containing protein 4 enhances autophagy and lysosome tethering in response to Interleukin-4

Publikováno v: JOURNAL OF CELL BIOLOGY
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
research@ua; Vol 6 (2015); 40
research@ua; vol. 6 (2015); 40
The Journal of Cell Biology

Interleukin-4 boosts the capacity of dendritic cells to present endogenous antigens on MHC II and to resist bacterial infection through a mechanism shown to be partially dependent on RUFY4 expression.
Autophagy is a key degradative pathway coord

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25d8f30272ab8fbdcc12e140bb344c14
https://biblio.ugent.be/publication/6973793

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Quantitative proteomics reveals the induction of mitophagy in tumor necrosis factor-α-activated (TNFα) macrophages

Autor: Olivier Caron-Lizotte, Michel Desjardins, Christina Bell, Magali Chemali, Pierre Thibault, Jonathan Boulais, Luc English

Publikováno v: Molecularcellular proteomics : MCP. 12(9)

Macrophages play an important role in innate and adaptive immunity as professional phagocytes capable of internalizing and degrading pathogens to derive antigens for presentation to T cells. They also produce pro-inflammatory cytokines such as tumor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4905f1d66a13004ecff6e67f65a26e30
https://pubmed.ncbi.nlm.nih.gov/23674617

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Inhibition of the Host Translation Shutoff Response by Herpes Simplex Virus 1 Triggers Nuclear Envelope-Derived Autophagy

Autor: Christiane Rondeau, Roger Lippé, Michel Desjardins, Kerstin Radtke, Luc English, David A. Leib

Macroautophagy is a cellular pathway that degrades intracellular pathogens and contributes to antigen presentation. Herpes simplex virus 1 (HSV-1) infection triggers both macroautophagy and an additional form of autophagy that uses the nuclear envelo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1184ef58f460e8d5bd948493db168fa5
https://europepmc.org/articles/PMC3624196/

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Alternative pathways for MHC class I presentation: a new function for autophagy

Autor: Kerstin Radtke, Magali Chemali, Michel Desjardins, Luc English

Publikováno v: Cellular and molecular life sciences : CMLS. 68(9)

The classical view that endogenous antigens are processed by the proteasome and loaded on MHC class I molecules in the endoplasmic reticulum, while exogenous antigens taken up by endocytosis or phagocytosis are degraded and loaded on MHC class II in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2fa3121c7d496d1ca3b905c6bd54cf0
https://pubmed.ncbi.nlm.nih.gov/21390546

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