Zobrazeno 1 - 10
of 148
pro vyhledávání: '"Lubor Borsig"'
Autor:
Monika Dúcka, Martina Kučeríková, Filip Trčka, Jakub Červinka, Elisabetta Biglieri, Jan Šmarda, Lubor Borsig, Petr Beneš, Lucia Knopfová
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 3, Pp 326-336 (2021)
The transcription factor c-Myb can be involved in the activation of many genes with protumorigenic function; however, its role in breast cancer (BC) development is still under discussion. c-Myb is considered as a tumor-promoting factor in the early p
Externí odkaz:
https://doaj.org/article/321b17b6de55437f812950b98e26ab4a
Autor:
Jesus F. Glaus Garzon, Chiara Pastrello, Igor Jurisica, Michael O. Hottiger, Roland H. Wenger, Lubor Borsig
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 22, Iss 12, Pp 745-758 (2020)
Hypoxia and inflammation are key factors for colorectal cancer tumorigenesis. The colonic epithelium belongs to the tissues with the lowest partial pressure of oxygen in the body, and chronic inflammation is associated with an increased chance to dev
Externí odkaz:
https://doaj.org/article/71e1ac146d6c4409bb0448ce83cf2137
Autor:
Dilara Sahin, Natalia Arenas-Ramirez, Matthias Rath, Ufuk Karakus, Monika Hümbelin, Merel van Gogh, Lubor Borsig, Onur Boyman
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
IL-2/anti-IL-2 complexes have been proposed to curtail the severe adverse effects associated with IL-2 immunotherapy. Here, the authors, by integrating unmutated human IL-2 in the antigen binding groove of an anti-IL-2 monoclonal antibody, generate a
Externí odkaz:
https://doaj.org/article/bccae141645e49d6828a1fe5efe66a25
Autor:
Marko Roblek, Julia Bicher, Merel van Gogh, Attila György, Rita Seeböck, Bozena Szulc, Markus Damme, Mariusz Olczak, Lubor Borsig, Daria E. Siekhaus
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Solute carriers are increasingly recognized as participating in a plethora of pathologies, including cancer. We describe here the involvement of the orphan solute carrier Major Facilitator Superfamily Domain-containing protein 1 (MFSD1) in the regula
Externí odkaz:
https://doaj.org/article/ed86311871294197b5ee5a4232875d03
Autor:
Tomas Bertok, Aniko Bertokova, Eduard Jane, Michal Hires, Juvissan Aguedo, Maria Potocarova, Ludovit Lukac, Alica Vikartovska, Peter Kasak, Lubor Borsig, Jan Tkac
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Colorectal cancer (CRC) is one of the most common types of cancer among men and women worldwide. Efforts are currently underway to find novel and more cancer-specific biomarkers that could be detected in a non-invasive way. The analysis of aberrant g
Externí odkaz:
https://doaj.org/article/d30e52d4fa0141e48b288a89a7f17fed
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
TGFβ overexpression is commonly detected in cancer patients and correlates with poor prognosis and metastasis. Cancer progression is often associated with an enhanced recruitment of myeloid-derived cells to the tumor microenvironment. Here we show t
Externí odkaz:
https://doaj.org/article/de470c0be9224bdbbb3aae21b447f81c
Autor:
Valentina Mele, Camilla Basso, Valeria Governa, Jesus F. Glaus Garzon, Manuele G. Muraro, Silvio Däster, Christian A. Nebiker, Robert Mechera, Martin Bolli, Alexander Schmidt, Roger Geiger, Giulio C. Spagnoli, Dimitri Christoforidis, Pietro E. Majno, Lubor Borsig, Giandomenica Iezzi
Publikováno v:
Cancers, Vol 14, Iss 8, p 2024 (2022)
Stromal infiltration is associated with poor prognosis in human colon cancers. However, the high heterogeneity of human tumor-associated stromal cells (TASCs) hampers a clear identification of specific markers of prognostic relevance. To address thes
Externí odkaz:
https://doaj.org/article/315a6c857cff489f92ca117dca6044f5
Autor:
Anna Lorentzen, Paul F. Becker, Jan Kosla, Massimo Saini, Kathrin Weidele, Paolo Ronchi, Corinna Klein, Monika J. Wolf, Felix Geist, Bastian Seubert, Marc Ringelhan, Daniela Mihic-Probst, Knud Esser, Marko Roblek, Felix Kuehne, Gaia Bianco, Tracy O’Connor, Quentin Müller, Kathleen Schuck, Sebastian Lange, Daniel Hartmann, Saskia Spaich, Olaf Groß, Jochen Utikal, Sebastian Haferkamp, Martin R. Sprick, Amruta Damle-Vartak, Alexander Hapfelmeier, Norbert Hüser, Ulrike Protzer, Andreas Trumpp, Dieter Saur, Nachiket Vartak, Christoph A. Klein, Bernhard Polzer, Lubor Borsig, Mathias Heikenwalder
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-20 (2018)
Polarisation of metastasising cancer cells in circulation has not been investigated before. Here the authors identify single cell polarity as a distinct polarisation state of single cells in liquid phase, and show that perturbing single cell polarity
Externí odkaz:
https://doaj.org/article/e4d4ca03df544a909e2ed53aef5fd83a
Autor:
Heinz Läubli, Lubor Borsig
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Cell-cell interactions and cell adhesion are key mediators of cancer progression and facilitate hallmarks of cancer including immune evasion and metastatic dissemination. Many cell adhesion molecules within the tumor microenvironment are changed and
Externí odkaz:
https://doaj.org/article/3d5fc860e4f64d3b86f2998b9e1f1ccf
Autor:
Marko Roblek, Elisabeth Strutzmann, Christina Zankl, Tiziana Adage, Mathias Heikenwalder, Aid Atlic, Roland Weis, Andreas Kungl, Lubor Borsig
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 18, Iss 1, Pp 49-59 (2016)
The CCL2-CCR2 chemokine axis has an important role in cancer progression where it contributes to metastatic dissemination of several cancer types (e.g., colon, breast, prostate). Tumor cell–derived CCL2 was shown to promote the recruitment of CCR2+
Externí odkaz:
https://doaj.org/article/f208b9b9543a4798b6689d205d549d5e