Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Lubna M. Mehdawi"'
Publikováno v:
Cells, Vol 12, Iss 22, p 2658 (2023)
WNT/β-catenin signaling is essential for colon cancer development and progression. WNT5A (ligand of non-canonical WNT signaling) and its mimicking peptide Foxy5 impair β-catenin signaling in colon cancer cells via unknown mechanisms. Therefore, we
Externí odkaz:
https://doaj.org/article/20cc8fd1bcaa4b21ac615d6dc4df5778
Autor:
Roger Olsson, Pujarini Dash, Karin Hellman, Lubna M. Mehdawi, Souvik Ghatak, Shakti Ranjan Satapathy, Anita Sjölander, Fredrik Ek, Geriolda Topi
Publikováno v:
British Journal of Cancer. 126:586-597
Background Despite intense research, the prognosis for patients with advanced colorectal cancer (CRC) remains poor. The prostaglandin D2 receptors DP1 and DP2 are explored here as potential therapeutic targets for advanced CRC. Methods A CRC cohort w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ad3f845fe101e21f1ebcd03714d955d8
https://doi.org/10.1038/s41416-021-01595-4
https://doi.org/10.1038/s41416-021-01595-4
Autor:
Sjölander, Souvik Ghatak, Syrina F. Mehrabi, Lubna M. Mehdawi, Shakti Ranjan Satapathy, Anita
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 2; Pages: 793
Colorectal cancer (CRC) is one of the leading causes of cancer-related mortality worldwide. The current TNM (Tumor, Node, and Metastasis) classification approach is suboptimal in determining the prognosis of CRC patients. The prognosis for CRC is aff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::d25a72bbba292af311f6538f2567eed5
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 23, Iss 793, p 793 (2022)
International Journal of Molecular Sciences, Vol 23, Iss 793, p 793 (2022)
Colorectal cancer (CRC) is one of the leading causes of cancer-related mortality worldwide. The current TNM (Tumor, Node, and Metastasis) classification approach is suboptimal in determining the prognosis of CRC patients. The prognosis for CRC is aff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::5005011e4ad51c26823956f219cb6b79
http://europepmc.org/articles/PMC8776147
http://europepmc.org/articles/PMC8776147
Publikováno v:
Pharmacology of the WNT Signaling System ISBN: 9783030854980
WNT signalling is known to be a crucial regulator of embryonic development and tissue homeostasis. Aberrant expression of WNT signalling elements or their mutations has been implicated in carcinogenesis and/or the progression of several different can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::86b1c20a86afdd8433ffb7fc0424c42b
https://doi.org/10.1007/164_2021_528
https://doi.org/10.1007/164_2021_528
Autor:
Pujarini, Dash, Souvik, Ghatak, Geriolda, Topi, Shakti Ranjan, Satapathy, Fredrik, Ek, Karin, Hellman, Roger, Olsson, Lubna M, Mehdawi, Anita, Sjölander
Publikováno v:
Br J Cancer
BACKGROUND: Despite intense research, the prognosis for patients with advanced colorectal cancer (CRC) remains poor. The prostaglandin D(2) receptors DP1 and DP2 are explored here as potential therapeutic targets for advanced CRC. METHODS: A CRC coho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::caf859d635056c19ce1a07ac725a4da9
https://pubmed.ncbi.nlm.nih.gov/34750492
https://pubmed.ncbi.nlm.nih.gov/34750492
Autor:
Shakti Ranjan Satapathy, Lubna M. Mehdawi, Janina Osman, Wondossen Sime, Fredrik Ek, Karin Hellman, Anita Sjölander, Roger Olsson, Geriolda Topi
Publikováno v:
Oncogenesis, Vol 9, Iss 8, Pp 1-16 (2020)
Oncogenesis
Oncogenesis
Inflammation is an established risk factor for colorectal cancer. We and others have shown that colorectal cancer patients with elevated cysteinyl leukotriene receptor 2 (CysLT2R) and 15-hydroxyprostaglandin dehydrogenase (15-PGDH) levels exhibit goo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a52313d5d77aeb346e4a7a1940759d1
https://doi.org/10.1038/s41389-020-00256-0
https://doi.org/10.1038/s41389-020-00256-0
Publikováno v:
Molecular Oncology. 10:1415-1429
The tumor suppressor 15‐hydroxyprostaglandin dehydrogenase (15‐PGDH) is the key enzyme in prostaglandin E2 catabolism and is down‐regulated in colorectal cancer (CRC) tissue. Canonical Wnt signaling is frequently elevated in colon cancers and h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf73ae5ae270005ebd7ba94e6c88f761
https://doi.org/10.1016/j.molonc.2016.07.011
https://doi.org/10.1016/j.molonc.2016.07.011
Publikováno v:
Acta Oncologica. 55:1434-1442
Inflammatory cells and inflammatory mediators play an important role in colorectal cancer (CRC). Previous studies have shown that CRC patients with increased expression of cysteinyl leukotriene receptor 1 (CysLTR1) have a poorer prognosis, and Cysltr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8306379feaf59f1f8db43ff8bb9a9b9
https://doi.org/10.1080/0284186x.2016.1198493
https://doi.org/10.1080/0284186x.2016.1198493
Publikováno v:
Cancer Research. 79:2997-2997
Prostaglandin E2 (PGE2) is a crucial regulator of colon cancer (CC), an inflammation associated cancer. Tumor suppressor 15-hydroxyprostglandin dehydrogenase (15-PGDH) is a PGE2 degrading enzyme but is often downregulated in CC. Interestingly, CC-pat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b4c3d1bd3cfc583869d3f1df33f3507
https://doi.org/10.1158/1538-7445.am2019-2997
https://doi.org/10.1158/1538-7445.am2019-2997