Spectrum and Clinical Outcome of Motility Disorders on High-Resolution Esophageal Manometry: A Study From a Tertiary Center on Patients With Dysphagia in Pakistan

Autor: Farheen Lubna Hashmi, Adeel Abid, Safia Awan, Hareem Rehman, Shahab Abid

Publikováno v: Cureus

Objective This study aimed to evaluate the outcome of high-resolution esophageal manometry (HRM) in the diagnosis of esophageal motility disorders in a Pakistani population. It also evaluates the outcomes of management of patients with esophageal dys

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13489e08e273c52b4f490c9b160a73be
https://doi.org/10.7759/cureus.12088

Discovery of highly selective inhibitors of calmodulin-dependent kinases that restore insulin sensitivity in the diet-induced obese in vivo mouse model

Autor: Fedor Berditchevski, Lubna Hashmi, Stevenson Brett W, Graziella Greco, Juliet Morgan, Alessio Atzori, Sundaresan Rajesh, Anna M. Grabowska, Divneet Kaur, Ana Varela, Alejandro Cabanillas, Huy V. Nguyen, Marc Lenoir, Sharon C. Cheetham, Greg P. Iacobini, Colin Kenyon, Christopher J. Weston, Christophe Fromont, Clare L. Box, Miguel Garzon, Brendan Leighton, D. Heulyn Jones, Jitendra Kumar, Fiona J. Sorrell, Steven P. Vickers, Sam Butterworth, C. John Harris, Paige Grant, Clara Redondo, Peter Fischer, Michael Overduin, Andreas Krämer, Vera Novitskaya, Stefan Knapp

Publikováno v: Butterworth, S & Garzon Sanz, M 2020, ' Discovery of highly selective inhibitors of calmodulin-dependent kinases that restore insulin sensitivity in the diet-induced obese in vivo mouse model ', Journal of Medicinal Chemistry, vol. 63, no. 13, pp. 6784-6801 . https://doi.org/10.1021/acs.jmedchem.9b01803
Journal of medicinal chemistry 63(13), 6784-6801 (2020). doi:10.1021/acs.jmedchem.9b01803

Polymorphisms in the region of the calmodulin-dependent kinase isoform D (CaMK1D) gene are associated with increased incidence of diabetes, with the most common polymorphism resulting in increased recognition by transcription factors and increased pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5530ea1a6282165c274343b752573f14
https://doi.org/10.1021/acs.jmedchem.9b01803

Usefulness of Esophageal Manometry in Management of Patients With Non-Structural Dysphagia With Normal Endoscopy

Autor: Adeel Abid, Shahab Abid, Farhana Kayani, Farheen Lubna Hashmi, Safia Awan

Publikováno v: American Journal of Gastroenterology. 113:S1540-S1541

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fc12aef9ad52702a904b1caf64cbb9df
https://doi.org/10.14309/00000434-201810001-02775

Natural History and Predictors of Poor Outcome of Non-Acetaminophen Induced Severe Acute Liver Injury

Autor: Ajeet Kumar Lohana, Shahab Abid, Farheen Lubna Hashmi, Maira Mustafa

Publikováno v: American Journal of Gastroenterology. 113:S1582

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a13dc480fd914f725f156badd0a01a69
https://doi.org/10.14309/00000434-201810001-02856

A fluorescence-based assay suitable for quantitative analysis of deadenylase enzyme activity

Autor: Peter Fischer, Lubna Hashmi, Loyin Olotu-Umoren, Gopal P. Jadhav, Blessing Oveh, Ishwinder Kaur, G. Sebastiaan Winkler, Maryati Maryati

Publikováno v: Nucleic Acids Research

In eukaryotic cells, the shortening and removal of the poly(A) tail of cytoplasmic mRNA by deadenylase enzymes is a critical step in post-transcriptional gene regulation. The ribonuclease activity of deadenylase enzymes is attributed to either a DEDD

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ba38dcc3738b467d3b6ce86f99c81ee
https://pubmed.ncbi.nlm.nih.gov/24170810