Syncytiotrophoblast Extracellular Vesicles From Late-Onset Preeclampsia Placentae Suppress Pro-Inflammatory Immune Response in THP-1 Macrophages

Autor: Toluwalase Awoyemi, Carolina Motta-Mejia, Wei Zhang, Lubna Kouser, Kirsten White, Neva Kandzija, Fatimah S. Alhamlan, Adam P. Cribbs, Dionne Tannetta, Emily Mazey, Christopher Redman, Uday Kishore, Manu Vatish

Publikováno v: Frontiers in Immunology, Vol 12 (2021)

Syncytiotrophoblast derived Extracellular Vesicles (STBEV) from normal pregnancy (NP) have previously been shown to interact with circulating monocytes and B cells and induce pro-inflammatory cytokine release. Early-onset preeclampsia (EOPE) is assoc

Externí odkaz: https://doaj.org/article/edbd2d28f34d4c6ea3b28d81db7ea5c4

Entry Inhibition and Modulation of Pro-Inflammatory Immune Response Against Influenza A Virus by a Recombinant Truncated Surfactant Protein D

Autor: Mohammed N. Al-Ahdal, Valarmathy Murugaiah, Praveen M. Varghese, Suhair M. Abozaid, Iram Saba, Ahmed Ali Al-Qahtani, Ansar A. Pathan, Lubna Kouser, Béatrice Nal, Uday Kishore

Publikováno v: Frontiers in Immunology, Vol 9 (2018)

Surfactant protein D (SP-D) is expressed in the mucosal secretion of the lung and contributes to the innate host defense against a variety of pathogens, including influenza A virus (IAV). SP-D can inhibit hemagglutination and infectivity of IAV, in a

Externí odkaz: https://doaj.org/article/4ea77c720e15403cbdecca94b9969d20

Human Properdin Opsonizes Nanoparticles and Triggers a Potent Pro-inflammatory Response by Macrophages without Involving Complement Activation

Autor: Lubna Kouser, Basudev Paudyal, Anuvinder Kaur, Gudrun Stenbeck, Lucy A. Jones, Suhair M. Abozaid, Cordula M. Stover, Emmanuel Flahaut, Robert B. Sim, Uday Kishore

Publikováno v: Frontiers in Immunology, Vol 9 (2018)

Development of nanoparticles as tissue-specific drug delivery platforms can be considerably influenced by the complement system because of their inherent pro-inflammatory and tumorigenic consequences. The complement activation pathways, and its recog

Externí odkaz: https://doaj.org/article/8ba3ed2e02734ff3901f953cd5b57e3c

Correction: Context-dependent effects of IL-2 rewire immunity into distinct cellular circuits

Autor: Carly E. Whyte, Kailash Singh, Oliver T. Burton, Meryem Aloulou, Lubna Kouser, Rafael Valente Veiga, Amy Dashwood, Hanneke Okkenhaug, Samira Benadda, Alena Moudra, Orian Bricard, Stephanie Lienart, Pascal Bielefeld, Carlos P. Roca, Francisco José Naranjo-Galindo, Félix Lombard-Vadnais, Steffie Junius, David Bending, Masahiro Ono, Tino Hochepied, Timotheus Y.F. Halim, Susan Schlenner, Sylvie Lesage, James Dooley, Adrian Liston

Publikováno v: Journal of Experimental Medicine. 219

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e4761a496ca7355d3cf0b7d24052147c
https://doi.org/10.1084/jem.2021239107142022c

Astrocyte-targeted gene delivery of interleukin 2 specifically increases brain-resident regulatory T cell numbers and protects against pathological neuroinflammation

Autor: Lidia Yshii, Emanuela Pasciuto, Pascal Bielefeld, Loriana Mascali, Pierre Lemaitre, Marika Marino, James Dooley, Lubna Kouser, Stijn Verschoren, Vasiliki Lagou, Hannelore Kemps, Pascal Gervois, Antina de Boer, Oliver T. Burton, Jérôme Wahis, Jens Verhaert, Samar H. K. Tareen, Carlos P. Roca, Kailash Singh, Carly E. Whyte, Axelle Kerstens, Zsuzsanna Callaerts-Vegh, Suresh Poovathingal, Teresa Prezzemolo, Keimpe Wierda, Amy Dashwood, Junhua Xie, Elien Van Wonterghem, Eline Creemers, Meryem Aloulou, Willy Gsell, Oihane Abiega, Sebastian Munck, Roosmarijn E. Vandenbroucke, Annelies Bronckaers, Robin Lemmens, Bart De Strooper, Ludo Van Den Bosch, Uwe Himmelreich, Carlos P. Fitzsimons, Matthew G. Holt, Adrian Liston

Publikováno v: Nature Immunology
Nature Immunology, 2022, 23 (6), pp.878-891. ⟨10.1038/s41590-022-01208-z⟩
Nature Immunology, 23(6), 878-891. Nature Publishing Group
NATURE IMMUNOLOGY

The ability of immune-modulating biologics to prevent and reverse pathology has transformed recent clinical practice. Full utility in the neuroinflammation space, however, requires identification of both effective targets for local immune modulation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46ab80cea5714e906bd81ffe84b531cc
https://lirias.kuleuven.be/handle/20.500.12942/696232