Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Lubing Zhu"'
Autor:
Lu Hong, Kaiwei Xu, Ming Yang, Lubing Zhu, Chunqu Chen, Liu Xu, Weihao Zhu, Lufei Jin, Linwei Wang, Jie Lin, Jianhua Wang, Wenzhi Ren, Aiguo Wu
Publikováno v:
Materials Today Bio, Vol 26, Iss , Pp 101106- (2024)
Breaking the poor permeability of immune checkpoint inhibitors (ICIs) caused by the stromal barrier and reversing the immunosuppressive microenvironment are significant challenges in pancreatic cancer immunotherapy. In this study, we synthesized core
Externí odkaz:
https://doaj.org/article/e808946d234f4920874f9d829684b703
Publikováno v:
Clinics, Vol 68, Iss 10, Pp 1350-1357 (2013)
OBJECTIVE: To investigate the antifibrotic effects of crocetin in scleroderma fibroblasts and in sclerotic mice. METHODS: Skin fibroblasts that were isolated from three systemic scleroderma (SSc) patients and three healthy subjects were treated with
Externí odkaz:
https://doaj.org/article/1438bba37e1e46a0ac1d501eb3057c49
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e85032 (2013)
Recent reports have demonstrated that endothelial cells are involved in vascular inflammatory injury in systemic sclerosis (SSc) and interleukin-17A (IL-17A) plays a crucial role in the pathogenesis of SSC. However, little is known about the effects
Externí odkaz:
https://doaj.org/article/b73900e8931c4134a66adf488389f9e8
Autor:
Chaofan, Liu, Jiaxuan, Tang, Shiying, Liu, Chen, Shen, Xing, Zhou, Jinghao, Lu, Ming, Li, Lubing, Zhu
Publikováno v:
Journal of Dermatological Science. 108:127-137
Pyroptosis is a newly discovered type of programmed cell death associated with inflammatory and fibrotic diseases. Macrophages play an important role in inducing early immune inflammation in systemic sclerosis (SSc).To investigate the effect of macro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d466cf937540adeb7fa5b4bfece610b
https://doi.org/10.1016/j.jdermsci.2022.12.006
https://doi.org/10.1016/j.jdermsci.2022.12.006
Autor:
Chaofan, Liu, Jiaxuan, Tang, Wei, Luo, Shiying, Liu, Xiaolei, Sun, Wenxuan, Hong, Xing, Zhou, Jinghao, Lu, Ming, Li, Lubing, Zhu
Publikováno v:
Rheumatology. 62:934-945
Objective To clarify the role of RNA polymerase III A (POLR3A)/type I IFN in the pathogenesis of SSc. Methods Cytosolic DNA and stimulator of IFN genes (STING) pathway in skin or serum of SSc patients were detected by immunofluorescence, immunohistoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::761b9ccd2df6509242b6a9c0da94ab39
https://doi.org/10.1093/rheumatology/keac324
https://doi.org/10.1093/rheumatology/keac324
Publikováno v:
Rheumatology (Oxford, England). 58(11)
Objectives To investigate whether autophagy mediates 2-methoxyestradiol (2-ME)-inhibited hypoxia-induced fibrosis and endothelial-to-mesenchymal transition (endoMT) in SSc. Methods Autophagy in the skin of SSc patients was assessed by transmission el
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b17ccf3bb503b5bc81896d8d4b5bd25
https://pubmed.ncbi.nlm.nih.gov/31049569
https://pubmed.ncbi.nlm.nih.gov/31049569
Publikováno v:
Rheumatology (Oxford, England). 57(9)
Objectives To investigate the mechanism of 2-methoxyestradiol (2-ME) in inhibiting hypoxia-induced collagen synthesis of fibroblasts in SSc. Methods The expressions of hypoxia-inducible factor 1 alpha (HIF-1α) and connective tissue growth factor (CT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88da0f905b05f20e428f2ac794cf3d79
https://pubmed.ncbi.nlm.nih.gov/29905853
https://pubmed.ncbi.nlm.nih.gov/29905853
Publikováno v:
Journal of Dermatological Science. 77:63-70
Summary Background The most dominant feature of systemic sclerosis (SSc) is fibrosis, which is caused by overproduction of collagen by fibroblasts. 2-Methoxyestradiol (2-ME) has exhibited disease-modifying activity in animal models of rheumatoid arth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c89141a1b51a64a715886ebe30692654
https://doi.org/10.1016/j.jdermsci.2014.10.007
https://doi.org/10.1016/j.jdermsci.2014.10.007
Publikováno v:
Clinical and Experimental Dermatology. 37:395-403
Summary Background. Overproduction of type I collagen in fibroblasts of systemic sclerosis (SSc) is the hallmark of fibrosis. Establishment and characterization of the phenotype of SSc fibroblasts has been hindered by the heterogeneity between fibrob
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b05bf34f138c4c1646d5f723cd47891
https://doi.org/10.1111/j.1365-2230.2011.04254.x
https://doi.org/10.1111/j.1365-2230.2011.04254.x
Publikováno v:
Arthritis & Rheumatism. 60:1472-1483
Objective To investigate the relative abundance and activities of Th17 cells and natural Treg cells in systemic lupus erythematosus (SLE). Methods Blood samples were collected from 50 adult patients with SLE. Samples were processed to detect Th17 cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bccdcab859c64663372f368365e9761
https://doi.org/10.1002/art.24499
https://doi.org/10.1002/art.24499