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Discovery and optimization of a novel series of pyrazolyltetrahydropyran N-type calcium channel (Ca v 2.2) blockers for the treatment of pain.

Autor: Wall MJ; Janssen Research & Development, L.L.C., Welsh & McKean Roads, Spring House, PA 19477, USA. Electronic address: mwall2@its.jnj.com., Subasinghe NL; Janssen Research & Development, L.L.C., Welsh & McKean Roads, Spring House, PA 19477, USA., Winters MP; Janssen Research & Development, L.L.C., Welsh & McKean Roads, Spring House, PA 19477, USA., Lubin ML; Janssen Research & Development, L.L.C., Welsh & McKean Roads, Spring House, PA 19477, USA., Finley MFA; Janssen Research & Development, L.L.C., Welsh & McKean Roads, Spring House, PA 19477, USA., Qin N; Janssen Research & Development, L.L.C., Welsh & McKean Roads, Spring House, PA 19477, USA., Brandt MR; Janssen Research & Development, L.L.C., Welsh & McKean Roads, Spring House, PA 19477, USA., Neeper MP; Janssen Research & Development, L.L.C., Welsh & McKean Roads, Spring House, PA 19477, USA., Schneider CR; Janssen Research & Development, L.L.C., Welsh & McKean Roads, Spring House, PA 19477, USA., Colburn RW; Janssen Research & Development, L.L.C., Welsh & McKean Roads, Spring House, PA 19477, USA., Flores CM; Janssen Research & Development, L.L.C., Welsh & McKean Roads, Spring House, PA 19477, USA., Sui Z; Janssen Research & Development, L.L.C., Welsh & McKean Roads, Spring House, PA 19477, USA.

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2018 Dec 15; Vol. 28 (23-24), pp. 3780-3783. Date of Electronic Publication: 2018 Oct 12.

Discovery and SAR of a novel series of 2,4,5,6-tetrahydrocyclopenta[c]pyrazoles as N-type calcium channel inhibitors.

Autor: Winters MP; Janssen Research and Development, LLC, 1400 McKean Rd., Spring House, PA 19477, USA. Electronic address: mwinter4@its.jnj.com., Subasinghe N; Janssen Research and Development, LLC, 1400 McKean Rd., Spring House, PA 19477, USA., Wall M; Janssen Research and Development, LLC, 1400 McKean Rd., Spring House, PA 19477, USA., Beck E; Janssen Research and Development, LLC, 1400 McKean Rd., Spring House, PA 19477, USA., Brandt MR; Janssen Research and Development, LLC, 1400 McKean Rd., Spring House, PA 19477, USA., Finley MF; Janssen Research and Development, LLC, 1400 McKean Rd., Spring House, PA 19477, USA., Liu Y; Janssen Research and Development, LLC, 1400 McKean Rd., Spring House, PA 19477, USA., Lubin ML; Janssen Research and Development, LLC, 1400 McKean Rd., Spring House, PA 19477, USA., Neeper MP; Janssen Research and Development, LLC, 1400 McKean Rd., Spring House, PA 19477, USA., Qin N; Janssen Research and Development, LLC, 1400 McKean Rd., Spring House, PA 19477, USA., Flores CM; Janssen Research and Development, LLC, 1400 McKean Rd., Spring House, PA 19477, USA., Sui Z; Janssen Research and Development, LLC, 1400 McKean Rd., Spring House, PA 19477, USA.

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2014 May 01; Vol. 24 (9), pp. 2057-61. Date of Electronic Publication: 2014 Mar 28.

Novel, broad-spectrum anticonvulsants containing a sulfamide group: pharmacological properties of (S)-N-[(6-chloro-2,3-dihydrobenzo[1,4]dioxin-2-yl)methyl]sulfamide (JNJ-26489112).

Autor: McComsey DF; Research & Development, Janssen Pharmaceutical Companies of Johnson & Johnson , Spring House, Pennsylvania 19477-0776, United States., Smith-Swintosky VL, Parker MH, Brenneman DE, Malatynska E, White HS, Klein BD, Wilcox KS, Milewski ME, Herb M, Finley MF, Liu Y, Lubin ML, Qin N, Reitz AB, Maryanoff BE

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2013 Nov 27; Vol. 56 (22), pp. 9019-30. Date of Electronic Publication: 2013 Nov 11.