Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Lubica Muckova"'
Autor:
Eva Mezeiova, Lukas Prchal, Martina Hrabinova, Lubica Muckova, Lenka Pulkrabkova, Ondrej Soukup, Anna Misiachna, Jiri Janousek, Jakub Fibigar, Tomas Kucera, Martin Horak, Galina F. Makhaeva, Jan Korabecny
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 173, Iss , Pp 116399- (2024)
The search for novel drugs to address the medical needs of Alzheimer's disease (AD) is an ongoing process relying on the discovery of disease-modifying agents. Given the complexity of the disease, such an aim can be pursued by developing so-called mu
Externí odkaz:
https://doaj.org/article/567776fbc85843eba2bb66f04d9469c0
Autor:
Zofia Chrienova, Eugenie Nepovimova, Rudolf Andrys, Rafael Dolezal, Jana Janockova, Lubica Muckova, Lenka Fabova, Ondrej Soukup, Patrik Oleksak, Martin Valis, Jan Korabecny, José Marco-Contelles, Kamil Kuca
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 2605-2620 (2022)
Twenty-four novel compounds bearing tetrahydroacridine and N-propargyl moieties have been designed, synthesised, and evaluated in vitro for their anti-cholinesterase and anti-monoamine oxidase activities. Propargyltacrine 23 (IC50 = 21 nM) was the mo
Externí odkaz:
https://doaj.org/article/1b4b604d4ed2463eadfec515d42a5564
Autor:
Jaroslav Pejchal, Ales Tichy, Adela Kmochova, Lenka Fikejzlova, Klara Kubelkova, Marcela Milanova, Anna Lierova, Alzbeta Filipova, Lubica Muckova, Jana Cizkova
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Purpose: Insulin-like growth factor-1 (IGF-1) stimulates epithelial regeneration but may also induce life-threatening hypoglycemia. In our study, we first assessed its safety. Subsequently, we examined the effect of IGF-1 administered in different do
Externí odkaz:
https://doaj.org/article/dde1adc7d7e54647b7a2da64813cef20
Autor:
Barbora Svobodova, Lenka Pulkrabkova, Dawid Panek, Anna Misiachna, Marharyta Kolcheva, Rudolf Andrys, Jiri Handl, Jan Capek, Pavlina Nyvltova, Tomas Rousar, Lukas Prchal, Vendula Hepnarova, Martina Hrabinova, Lubica Muckova, Daniela Tosnerova, Galina Karabanovich, Vladimir Finger, Ondrej Soukup, Martin Horak, Jan Korabecny
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 11, p 9124 (2023)
Alzheimer’s disease (AD) is a complex disease with an unknown etiology. Available treatments, limited to cholinesterase inhibitors and N-methyl-d-aspartate receptor (NMDAR) antagonists, provide symptomatic relief only. As single-target therapies ha
Externí odkaz:
https://doaj.org/article/5997ebc1604b46dfa3bcaf7b7054b542
Autor:
Radomir Juza, Kristyna Stefkova, Wim Dehaen, Alena Randakova, Tomas Petrasek, Iveta Vojtechova, Tereza Kobrlova, Lenka Pulkrabkova, Lubica Muckova, Marko Mecava, Lukas Prchal, Eva Mezeiova, Kamil Musilek, Ondrej Soukup, Jan Korabecny
Publikováno v:
Biomolecules, Vol 11, Iss 9, p 1262 (2021)
In this pilot study, a series of new 3,4-dihydroquinolin-2(1H)-one derivatives as potential dopamine receptor D2 (D2R) modulators were synthesized and evaluated in vitro. The preliminary structure–activity relationship disclosed that compound 5e ex
Externí odkaz:
https://doaj.org/article/abb4ede6d98c4d9595af28bb1287f2f1
Autor:
Radek Sleha, Vera Radochova, Alexander Mikyska, Milan Houska, Radka Bolehovska, Sylva Janovska, Jaroslav Pejchal, Lubica Muckova, Pavel Cermak, Pavel Bostik
Publikováno v:
Antibiotics, Vol 10, Iss 4, p 392 (2021)
Clostridioides (C.) difficile is an important causative pathogen of nosocomial gastrointestinal infections in humans with an increasing incidence, morbidity, and mortality. The available treatment options against this pathogen are limited. The standa
Externí odkaz:
https://doaj.org/article/d75240ef772942e4af6a234a2d8c062c
Autor:
Alzbeta Filipova, Jan Marek, Radim Havelek, Jaroslav Pejchal, Marcela Jelicova, Jana Cizkova, Martina Majorosova, Lubica Muckova, Tomas Kucera, Lukas Prchal, Miroslav Psotka, Natalie Zivna, Darja Koutova, Zuzana Sinkorova, Martina Rezacova, Ales Tichy
Publikováno v:
Molecules, Vol 25, Iss 3, p 532 (2020)
The increasing risk of radiation exposure underlines the need for novel radioprotective agents. Hence, a series of novel 1-(2-hydroxyethyl)piperazine derivatives were designed and synthesized. Some of the compounds protected human cells against radia
Externí odkaz:
https://doaj.org/article/8e047d5c8c22403da51ebf57d1ca52df
Autor:
Barbora Svobodova, Eva Mezeiova, Vendula Hepnarova, Martina Hrabinova, Lubica Muckova, Tereza Kobrlova, Daniel Jun, Ondrej Soukup, María Luisa Jimeno, José Marco-Contelles, Jan Korabecny
Publikováno v:
Biomolecules, Vol 9, Iss 8, p 379 (2019)
Tacrine was the first drug to be approved for Alzheimer’s disease (AD) treatment, acting as a cholinesterase inhibitor. The neuropathological hallmarks of AD are amyloid-rich senile plaques, neurofibrillary tangles, and neuronal degeneration. The p
Externí odkaz:
https://doaj.org/article/fb20ff896efd4e35bc8a5bbdbb1a00d4
Autor:
Eva Mezeiova, Jan Korabecny, Vendula Sepsova, Martina Hrabinova, Petr Jost, Lubica Muckova, Tomas Kucera, Rafael Dolezal, Jan Misik, Katarina Spilovska, Ngoc Lam Pham, Lucia Pokrievkova, Jaroslav Roh, Daniel Jun, Ondrej Soukup, Daniel Kaping, Kamil Kuca
Publikováno v:
Molecules, Vol 22, Iss 8, p 1265 (2017)
Tacrine (THA), the first clinically effective acetylcholinesterase (AChE) inhibitor and the first approved drug for the treatment of Alzheimer’s disease (AD), was withdrawn from the market due to its side effects, particularly its hepatotoxicity. N
Externí odkaz:
https://doaj.org/article/fe0fff597e6d4ec9a5efe54879c94f4d
Autor:
Lenka Pulkrabkova, Lubica Muckova, Martina Hrabinova, Ales Sorf, Tereza Kobrlova, Petr Jost, Dagmar Bezdekova, Jan Korabecny, Daniel Jun, Ondrej Soukup
Publikováno v:
Archives of Toxicology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9f31f1ff6a31d2ed8e325cc5e1066fcf
https://doi.org/10.1007/s00204-023-03525-0
https://doi.org/10.1007/s00204-023-03525-0