Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Lubica Lacinová"'
Autor:
Eliyahu Dremencov, Henrieta Oravcova, Daniil Grinchii, Zuzana Romanova, Roman Dekhtiarenko, Lubica Lacinova, Daniela Jezova
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Background: There is growing evidence that the treatment of several mental disorders can potentially benefit from activation of delta-opioid receptors. In the future, delta-agonists with a safe pharmacological profile can be used for the treatment of
Externí odkaz:
https://doaj.org/article/46edd60e42a2417c90e34163c8920a2f
Autor:
Leos Cmarko, Robin N. Stringer, Bohumila Jurkovicova-Tarabova, Tomas Vacik, Lubica Lacinova, Norbert Weiss
Publikováno v:
Molecular Brain, Vol 15, Iss 1, Pp 1-5 (2022)
Abstract Low-voltage-activated T-type Ca2+ channels are key regulators of neuronal excitability both in the central and peripheral nervous systems. Therefore, their recruitment at the plasma membrane is critical in determining firing activity pattern
Externí odkaz:
https://doaj.org/article/8061933a66364f57af6eede9cdeef15d
Autor:
Verena Specht, Norbert Klugbauer, Georg Bohn, Shuiping Dai, Franz Hofmann, Elsé Marais, Lubica Lacinová
Publikováno v:
FEBS Letters. 470:189-197
The gamma subunit was initially identified as an auxiliary subunit of the skeletal muscle calcium channel complex. Evidence for the existence of further gamma subunits arose following the characterization of a genetic defect that induces epileptic se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec84204bf786fa4eb03b7df4f3af0d6f
https://doi.org/10.1016/s0014-5793(00)01306-5
https://doi.org/10.1016/s0014-5793(00)01306-5
Publikováno v:
The Journal of Neuroscience. 19:684-691
Sequence database searches with the α2δ subunit as probe led to the identification of two new genes encoding proteins with the essential properties of this calcium channel subunit. Primary structure comparisons revealed that the novel α2δ-2 and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3633c49f14bf983e471017e125ee45e2
https://doi.org/10.1523/jneurosci.19-02-00684.1999
https://doi.org/10.1523/jneurosci.19-02-00684.1999
Autor:
Robin N. Stringer, Bohumila Jurkovicova-Tarabova, Ivana A. Souza, Judy Ibrahim, Tomas Vacik, Waseem Mahmoud Fathalla, Jozef Hertecant, Gerald W. Zamponi, Lubica Lacinova, Norbert Weiss
Publikováno v:
Molecular Brain, Vol 14, Iss 1, Pp 1-5 (2021)
Abstract Developmental and epileptic encephalopathies (DEEs) are a group of severe epilepsies that are characterized by seizures and developmental delay. DEEs are primarily attributed to genetic causes and an increasing number of cases have been corr
Externí odkaz:
https://doaj.org/article/3f066df756e94d84ba7d997e8e58c750
Publikováno v:
Canadian journal of physiology and pharmacology. 87(11)
Cerebrocrast is a novel lipophilic dihydropyridine derivative with potential neuroprotective and antidiabetic properties. We have analyzed its interaction with L-type (CaV1.2b) and T-type (CaV3.1) calcium channels using a whole-cell patch clamp in HE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc753813e9cd4090b9cd2795988c5c5b
https://pubmed.ncbi.nlm.nih.gov/19935900
https://pubmed.ncbi.nlm.nih.gov/19935900
Autor:
Lubica, Lacinová, N, Klugbauer
Publikováno v:
Archives of biochemistry and biophysics. 425(2)
Modulatory effects of auxiliary alpha(2)delta(2) and gamma(5) subunits on intramembrane charge movement originating from the expressed Ca(v)3.1 calcium channel were investigated. Inward current was blocked by 1mM La(3+). Voltage dependences of Q(on)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a770909037c37b2b0914bc19ff7d76b5
https://pubmed.ncbi.nlm.nih.gov/15111129
https://pubmed.ncbi.nlm.nih.gov/15111129
Publikováno v:
FEBS letters. 531(2)
Intramembrane charge movement originating from Cav3.1 (T-type) channel expressed in HEK 293 cells was investigated. Ion current was blocked by 1 mM La3+. Charge movement was detectable for depolarizations above approximately -70 mV and saturated abov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a2ac5d176ab958750ca9361cbdeabd0
https://pubmed.ncbi.nlm.nih.gov/12417318
https://pubmed.ncbi.nlm.nih.gov/12417318
Autor:
Robin N. Stringer, Bohumila Jurkovicova-Tarabova, Sun Huang, Omid Haji-Ghassemi, Romane Idoux, Anna Liashenko, Ivana A. Souza, Yuriy Rzhepetskyy, Lubica Lacinova, Filip Van Petegem, Gerald W. Zamponi, Roger Pamphlett, Norbert Weiss
Publikováno v:
Molecular Brain, Vol 13, Iss 1, Pp 1-11 (2020)
Abstract Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by the progressive loss of cortical, brain stem and spinal motor neurons that leads to muscle weakness and death. A previous study implicated CACNA1H encoding
Externí odkaz:
https://doaj.org/article/aa77ecf927be4dd78a092c2d4008c1cd
Autor:
Hana Hribkova, Ondrej Svoboda, Elis Bartecku, Jana Zelinkova, Jana Horinkova, Lubica Lacinova, Martin Piskacek, Bretislav Lipovy, Ivo Provaznik, Joel C. Glover, Tomas Kasparek, Yuh-Man Sun
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 16 (2022)
The cellular pathology of schizophrenia and the potential of antipsychotics to target underlying neuronal dysfunctions are still largely unknown. We employed glutamatergic neurons derived from induced pluripotent stem cells (iPSC) obtained from schiz
Externí odkaz:
https://doaj.org/article/0aefd9d182954b02b41cbe39e14830e3