Zobrazeno 1 - 10 of 13 pro vyhledávání: '"Lubica Kalachova"'
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Akademický článek
Inhibition of GlcNAc-Processing Glycosidases by C-6-Azido-NAG-Thiazoline and Its Derivatives
Autor: Jana Krejzová, Petr Šimon, Lubica Kalachova, Natallia Kulik, Pavla Bojarová, Petr Marhol, Helena Pelantová, Josef Cvačka, Rüdiger Ettrich, Kristýna Slámová, Vladimír Křen
Publikováno v: Molecules, Vol 19, Iss 3, Pp 3471-3488 (2014)
NAG-thiazoline is a strong competitive inhibitor of GH20 β-N-acetyl- hexosaminidases and GH84 β-N-acetylglucosaminidases. Here, we focused on the design, synthesis and inhibition potency of a series of new derivatives of NAG-thiazoline modified at
Externí odkaz: https://doaj.org/article/270deca1616f40fea5147629b7702a11
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3
Synthesis of nucleoside mono- and triphosphates bearing oligopyridine ligands, their incorporation into DNA and complexation with transition metals
Autor: Michal Hocek, Lubica Kalachova, Radek Pohl
Publikováno v: Org. Biomol. Chem.. 10:49-55
Modified nucleoside mono- (dA(R)MPs and dC(R)MPs) and triphosphates (dA(R)TPs and dC(R)TPs) bearing bipyridine or terpyridine ligands attached via acetylene linker were prepared by single-step aqueous-phase Sonogashira cross-coupling of 7-iodo-7-deaz
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e231e2b664cec4c060d9ea6566c47a9
https://doi.org/10.1039/c1ob06359f
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4
Inhibition of microbial β-N-acetylhexosaminidases by 4-deoxy- and galacto-analogues of NAG-thiazoline
Autor: Jana Krejzová, Petr Šimon, Lubica Kalachova, Vladimír Křen, Helena Pelantová, Kristýna Slámová
Publikováno v: Bioorganic & Medicinal Chemistry Letters. 24:5321-5323
NAG-thiazoline is a well-established competitive inhibitor of two physiologically relevant glycosidase families-β-N-acetylhexosaminidases (GH20) and β-N-acetylglucosaminidases (GH84). Based on the different substrate flexibilities of these enzyme g
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93746479cb8d94c9b02c1acf89ff7e09
https://doi.org/10.1016/j.bmcl.2014.09.066
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5
Base-Modified DNA Labeled by [Ru(bpy)3]2+ and [Os(bpy)3]2+ Complexes: Construction by Polymerase Incorporation of Modified Nucleoside Triphosphates, Electrochemical and Luminescent Properties, and Applications
Autor: Hana Cahová, Milan Vrabel, Hana Černocká, Peter Šebest, Petra Horáková, Michal Hocek, Hana Pivoňková, Radek Pohl, Luděk Havran, Miroslav Fojta, Lubica Kalachova
Publikováno v: Chemistry - A European Journal. 15:1144-1154
Modified 2'-deoxynucleoside triphosphates (dNTPs) bearing [Ru(bpy)(3)](2+) and [Os(bpy)(3)](2+) complexes attached via an acetylene linker to the 5-position of pyrimidines (C and U) or to the 7-position of 7-deazapurines (7-deaza-A and 7-deaza-G) hav
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::253b9b81edad467807a907464d16f11a
https://doi.org/10.1002/chem.200801538
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6
Synthesis of 2′-Deoxyuridine and 2′-Deoxycytidine Nucleosides Bearing Bipyridine and Terpyridine Ligands at Position 5
Autor: Michal Hocek, Lubica Kalachova, Radek Pohl
Publikováno v: Synthesis. 2009:105-112
A methodology for the syntheses of pyrimidine (C or U) 2-deoxyribonucleosidesbearing bipyridine or terpyridine ligands attached via acetyleneor phenylene linkers was developed based on single step cross-couplingreactions of unprotected 5-iodopyrimidi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::08642dd2b9b90cfea3bdc271b4c467f1
https://doi.org/10.1055/s-0028-1083266
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7
Inhibition of GlcNAc-processing glycosidases by C-6-azido-NAG-thiazoline and its derivatives
Autor: Kristýna Slámová, Jana Krejzová, Lubica Kalachova, Petr Marhol, Rüdiger Ettrich, Vladimír Křen, Petr Šimon, Josef Cvačka, Pavla Bojarová, Natallia Kulik, Helena Pelantová
Publikováno v: Molecules
Molecules; Volume 19; Issue 3; Pages: 3471-3488
Molecules, Vol 19, Iss 3, Pp 3471-3488 (2014)
NAG-thiazoline is a strong competitive inhibitor of GH20 β-N-acetyl- hexosaminidases and GH84 β-N-acetylglucosaminidases. Here, we focused on the design, synthesis and inhibition potency of a series of new derivatives of NAG-thiazoline modified at
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::921680fb6f978c0d57ee643e9fd566f7
https://pubmed.ncbi.nlm.nih.gov/24658571
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