Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Lubica Fialova"'
Autor:
Timotej Jankech, Ivana Gerhardtova, Petra Majerova, Juraj Piestansky, Lubica Fialova, Josef Jampilek, Andrej Kovac
Publikováno v:
Biomedicines, Vol 12, Iss 5, p 1003 (2024)
Many biologically active metabolites of the essential amino acid L-tryptophan (Trp) are associated with different neurodegenerative diseases and neurological disorders. Precise and reliable methods for their determination are needed. Variability in t
Externí odkaz:
https://doaj.org/article/f37c7e63e1214a8ba6b47b5cf8b540a9
Autor:
Klaudia Meskova, Katarina Martonova, Patricia Hrasnova, Kristina Sinska, Michaela Skrabanova, Lubica Fialova, Stefana Njemoga, Ondrej Cehlar, Olga Parmar, Petr Kolenko, Vladimir Pevala, Rostislav Skrabana
Publikováno v:
Antibodies, Vol 12, Iss 3, p 51 (2023)
Laboratory production of recombinant mammalian proteins, particularly antibodies, requires an expression pipeline assuring sufficient yield and correct folding with appropriate posttranslational modifications. Transient gene expression (TGE) in the s
Externí odkaz:
https://doaj.org/article/828e9ecbcbb147f5ba172aba1385983b
Autor:
Branislav Kovacech, Lubica Fialova, Peter Filipcik, Rostislav Skrabana, Monika Zilkova, Natalia Paulenka-Ivanovova, Andrej Kovac, Denisa Palova, Gabriela Paulikova Rolkova, Katarina Tomkova, Natalia Turic Csokova, Karina Markova, Michaela Skrabanova, Kristina Sinska, Neha Basheer, Petra Majerova, Jozef Hanes, Vojtech Parrak, Michal Prcina, Ondrej Cehlar, Martin Cente, Juraj Piestansky, Michal Fresser, Michal Novak, Monika Slavikova, Kristina Borsova, Viktoria Cabanova, Bronislava Brejova, Tomas Vinař, Jozef Nosek, Boris Klempa, Ludek Eyer, Vaclav Hönig, Martin Palus, Daniel Ruzek, Tereza Vyhlidalova, Petra Strakova, Blanka Mrazkova, Dagmar Zudova, Gizela Koubkova, Vendula Novosadova, Jan Prochazka, Radislav Sedlacek, Norbert Zilka, Eva Kontsekova
Publikováno v:
EBioMedicine, Vol 76, Iss , Pp 103818- (2022)
Summary: Background: The emergence of new SARS-CoV-2 variants of concern B.1.1.7 (Alpha), B.1.351 (Beta), P.1 (Gamma) and B.1.617.2 (Delta) that harbor mutations in the viral S protein raised concern about activity of current vaccines and therapeutic
Externí odkaz:
https://doaj.org/article/d503988bb92a4f8ca2f39b041da95550
Autor:
Petr Novak, Reinhold Schmidt, Eva Kontsekova, Branislav Kovacech, Tomas Smolek, Stanislav Katina, Lubica Fialova, Michal Prcina, Vojtech Parrak, Peter Dal-Bianco, Martin Brunner, Wolfgang Staffen, Michael Rainer, Matej Ondrus, Stefan Ropele, Miroslav Smisek, Roman Sivak, Norbert Zilka, Bengt Winblad, Michal Novak
Publikováno v:
Alzheimer’s Research & Therapy, Vol 10, Iss 1, Pp 1-16 (2018)
Abstract Background Neurofibrillary pathology composed of tau protein is closely correlated with severity and phenotype of cognitive impairment in patients with Alzheimer’s disease and non-Alzheimer’s tauopathies. Targeting pathological tau prote
Externí odkaz:
https://doaj.org/article/0a507430e9e248e6b42f67da7fb4aa06
Autor:
Martin, Cente, Tomas, Smolek, Stefan, Zorad, Lubica, Fialova, Natalia, Paulenka Ivanovova, Katarina, Krskova, Lucia, Balazova, Rostislav, Skrabana, Peter, Filipcik
Publikováno v:
General physiology and biophysics. 40:577-584
Neurodegeneration is associated with hypertension and disturbance in fat metabolism. The complex interaction of neurodegenerative processes with both metabolic changes and blood pressure is still not fully elucidated. Here we demonstrate that the exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19ca71e95f3f6aff7fc34c90381a3f04
https://doi.org/10.4149/gpb_2021037
https://doi.org/10.4149/gpb_2021037
Autor:
Norbert Zilka, Jozef Hanes, Branislav Kovacech, Martin Vyhnalek, Hlin Kvartsberg, Eva Kontsekova, Michal Novak, Oskar Hansson, Philip Scheltens, Kaj Blennow, Andrej Kovac, Eva Stevens, Henrik Zetterberg, Stanislav Katina, Charlotte E. Teunissen, Lubica Fialova, Jakub Hort, Lynn Boonkamp
Publikováno v:
Neurology, 95(22), e3026-e3035. Lippincott Williams and Wilkins
Hanes, J, Kovac, A, Kvartsberg, H, Kontsekova, E, Fialova, L, Katina, S, Kovacech, B, Stevens, E, Hort, J, Vyhnalek, M, Boonkamp, L, Novak, M, Zetterberg, H, Hansson, O, Scheltens, P, Blennow, K, Teunissen, C E & Zilka, N 2020, ' Evaluation of a novel immunoassay to detect p-tau Thr217 in the CSF to distinguish Alzheimer disease from other dementias ', Neurology, vol. 95, no. 22, pp. e3026-e3035 . https://doi.org/10.1212/WNL.0000000000010814
Neurology
article-version (Version of Record) 3
Hanes, J, Kovac, A, Kvartsberg, H, Kontsekova, E, Fialova, L, Katina, S, Kovacech, B, Stevens, E, Hort, J, Vyhnalek, M, Boonkamp, L, Novak, M, Zetterberg, H, Hansson, O, Scheltens, P, Blennow, K, Teunissen, C E & Zilka, N 2020, ' Evaluation of a novel immunoassay to detect p-tau Thr217 in the CSF to distinguish Alzheimer disease from other dementias ', Neurology, vol. 95, no. 22, pp. e3026-e3035 . https://doi.org/10.1212/WNL.0000000000010814
Neurology
article-version (Version of Record) 3
ObjectiveTo investigate whether tau phosphorylated at Thr217 (p-tau T217) assay in CSF can distinguish patients with Alzheimer disease (AD) from patients with other dementias and healthy controls.MethodsWe developed and validated a novel Simoa immuno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef0d0d0cc734b774fd16f0321103a151
https://doi.org/10.1212/wnl.0000000000010814
https://doi.org/10.1212/wnl.0000000000010814
Autor:
Lucia Balazova, Rostislav Skrabana, Peter Filipcik, Katarina Krskova, Tomas Smolek, Natalia Ivanovova, Lubica Fialova, Stefan Zorad, Martin Cente
Publikováno v:
Cellular and Molecular Neurobiology. 42:125-136
The close relationship between Alzheimer's disease (AD) and obesity was recognized many years ago. However, complete understanding of the pathological mechanisms underlying the interactions between degeneration of CNS and fat metabolism is still miss
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffa2d21341e62dc536b8f489f740121d
https://doi.org/10.1007/s10571-020-00972-6
https://doi.org/10.1007/s10571-020-00972-6
Autor:
Dominika Olešová, Dana Dobešová, Petra Majerová, Radana Brumarová, Aleš Kvasnička, Štěpán Kouřil, Eva Stevens, Jozef Hanes, Ľubica Fialová, Alena Michalicová, Juraj Piešťanský, Jakub Šinský, Petr Kaňovský, David Friedecký, Andrej Kováč
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-25 (2024)
Abstract Background Accumulation of tau leads to neuroinflammation and neuronal cell death in tauopathies, including Alzheimer’s disease. As the disease progresses, there is a decline in brain energy metabolism. However, the role of tau protein in
Externí odkaz:
https://doaj.org/article/4004cf4093e94f4d9b7e89e99d742211
Autor:
Duygu Tosun, Jozef Hanes, Branislav Kovacech, Tomas Hromadka, Lutz Froelich, Stanislav Katina, Lubica Fialova, Michal Prcina, Norbert Zilka, Andrej Kovac, Reinhold Schmidt, Eva Kontsekova, Martin Rakusa, Martin Cente, Carmen Prenn-Gologranc, Milica G. Kramberger, Stanislav Sutovsky, Peter Koson, Markus Otto, Stefan Ropele, Petr Novak, John Harrison, Michal Novak, Roman Sivak, Juraj Piestansky, Matej Ondrus, Jaroslav Galba, Miroslav Smisek, Maria Samcova, Eva Stevens, Jakub Hort, Bengt Winblad, Philip Scheltens, Vojtech Parrak, Peter Filipcik, Michal Fresser, Natalia Paulenka-Ivanovova
Publikováno v:
Nature Aging, 1(6), 521-534. Springer
Novak, P, Kovacech, B, Katina, S, Schmidt, R, Scheltens, P, Kontsekova, E, Ropele, S, Fialova, L, Kramberger, M, Paulenka-Ivanovova, N, Smisek, M, Hanes, J, Stevens, E, Kovac, A, Sutovsky, S, Parrak, V, Koson, P, Prcina, M, Galba, J, Cente, M, Hromadka, T, Filipcik, P, Piestansky, J, Samcova, M, Prenn-Gologranc, C, Sivak, R, Froelich, L, Fresser, M, Rakusa, M, Harrison, J, Hort, J, Otto, M, Tosun, D, Ondrus, M, Winblad, B, Novak, M & Zilka, N 2021, ' ADAMANT : a placebo-controlled randomized phase 2 study of AADvac1, an active immunotherapy against pathological tau in Alzheimer’s disease ', Nature Aging, vol. 1, no. 6, pp. 521-534 . https://doi.org/10.1038/s43587-021-00070-2
Novak, P, Kovacech, B, Katina, S, Schmidt, R, Scheltens, P, Kontsekova, E, Ropele, S, Fialova, L, Kramberger, M, Paulenka-Ivanovova, N, Smisek, M, Hanes, J, Stevens, E, Kovac, A, Sutovsky, S, Parrak, V, Koson, P, Prcina, M, Galba, J, Cente, M, Hromadka, T, Filipcik, P, Piestansky, J, Samcova, M, Prenn-Gologranc, C, Sivak, R, Froelich, L, Fresser, M, Rakusa, M, Harrison, J, Hort, J, Otto, M, Tosun, D, Ondrus, M, Winblad, B, Novak, M & Zilka, N 2021, ' ADAMANT : a placebo-controlled randomized phase 2 study of AADvac1, an active immunotherapy against pathological tau in Alzheimer’s disease ', Nature Aging, vol. 1, no. 6, pp. 521-534 . https://doi.org/10.1038/s43587-021-00070-2
Alzheimer’s disease (AD) pathology is partly characterized by accumulation of aberrant forms of tau protein. Here we report the results of ADAMANT, a 24-month double-blinded, parallel-arm, randomized phase 2 multicenter placebo-controlled trial of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9207a075a751b59f0b0c380b710aaf1
https://research.vumc.nl/en/publications/61abe2cc-82ad-4ac3-93be-d1cbc548881b
https://research.vumc.nl/en/publications/61abe2cc-82ad-4ac3-93be-d1cbc548881b
Autor:
Rostislav Skrabana, Vojtech Parrak, Zuzana Vince-Kazmerova, Stefan Ropele, Norbert Zilka, Michal Prcina, Michael Rainer, Lubica Fialova, Eva Kontsekova, Branislav Kovacech, Petr Novak, Miroslav Smisek, Roman Sivak, Peter Dal-Bianco, Stanislav Katina, Matej Ondrus, Wolfgang Staffen, Michal Novak, Martin Brunner, Reinhold Schmidt, Bengt Winblad
Publikováno v:
The Lancet Neurology. 16:123-134
Summary Background Neurofibrillary pathology composed of tau protein is a main correlate of cognitive impairment in patients with Alzheimer's disease. Immunotherapy targeting pathological tau proteins is therefore a promising strategy for disease-mod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::815d65fd312c8c400d5edc2b36cae44b
https://doi.org/10.1016/s1474-4422(16)30331-3
https://doi.org/10.1016/s1474-4422(16)30331-3