Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Luba Benimetskaya"'
Autor:
Jin-Feng Zhou, Cy A. Stein, Massimo Iacobelli, Kanyalakshmi Ayyanar, Joongho Shin, Anatoliy M. Voskresenskiy, Paul G. Richardson, Luba Benimetskaya, Cinara Echart, Sijian Wu
Publikováno v:
Blood. 112:4343-4352
Defibrotide (DF) is a mixture of porcine-derived single-stranded phosphodiester oligonucleotides (9-80-mer; average, 50-mer) that has been successfully used to treat severe hepatic veno-occlusive disease (sVOD) with multiorgan failure (MOF) in patien
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::800174f0e42739218b825dc93604cc14
https://doi.org/10.1182/blood-2008-04-149682
https://doi.org/10.1182/blood-2008-04-149682
Autor:
Mary Mehlig, Clifford Longley, Ping Peng, Virna Borowski, Gerrit Borchard, Cy A. Stein, Jing Xia, Prasanna Reddy, Luba Benimetskaya, Hong Zhao, Jack M. Lipman, Yue Zhang
Publikováno v:
Journal of Controlled Release. 119:143-152
In order to overcome the problems of enzymatic degradation and short plasma half life, which can limit the delivery of antisense oligonucleotides, and the potential immuno-stimulatory effects of CpG motifs, we utilized a polyethylene glycol (PEG) tec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65a06fb8be4f949a9346766814ae01ed
https://doi.org/10.1016/j.jconrel.2006.12.021
https://doi.org/10.1016/j.jconrel.2006.12.021
Autor:
Noah Kornblum, Cy A. Stein, John J. Rossi, Daniela Castanotto, Harilyn McMicken, Kanyalakshmi Ayyanar, Bob D. Brown, Luba Benimetskaya, Natalia V. Popova, Paul S. Miller, Johnathan Lai, Sijian Wu, Yin Chen
Publikováno v:
Clinical Cancer Research. 12:4940-4948
Purpose: Bcl-2 is an apoptotic protein that is highly expressed in advanced melanoma. Several strategies have been employed to target the expression of this protein, including G3139, an 18-mer phosphorothioate oligodeoxyribonucleotide targeted to the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cddd8d2e771ae27eea93db212d7186bc
https://doi.org/10.1158/1078-0432.ccr-06-1002
https://doi.org/10.1158/1078-0432.ccr-06-1002
Autor:
Paul S. Miller, Wenzhi Tan, Luba Benimetskaya, Marco Colombini, Johnathan C. Lai, Cy A. Stein
Publikováno v:
Proceedings of the National Academy of Sciences. 103:7494-7499
G3139, an 18-mer phosphorothioate antisense oligonucleotide targeted to the initiation codon region of the Bcl-2 mRNA, can induce caspase-dependent apoptosis via the intrinsic mitochondrial pathway in 518A2 and other melanoma cells. G3139-mediated ap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cce44c0c85e1909237a2b0dbd23b1f97
https://doi.org/10.1073/pnas.0602217103
https://doi.org/10.1073/pnas.0602217103
Autor:
Monika Baudler, James F. Beck, Carola Grebe, Uwe Pieles, Thomas Wagner, Michaela Römmele, Barbara Gonser, Hans-Peter Hofmann, Hanauer Guido, Petra Gimmnich, Volker Gekeler, C. A. Stein, Luba Benimetskaya, Thomas Maier, Sanders Karl, Astrid Leja
Publikováno v:
Oligonucleotides. 16:83-93
Several phosphorothioate antisense oligodeoxynucleotides (ODN) are developed to target factors potentially involved in tumor growth and apoptosis suppression. Among them, the 18-mer G3139 (Oblimersen), which targets Bcl-2, is currently being tested i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72b76ff85aa2e814be115fa6a060efec
https://doi.org/10.1089/oli.2006.16.83
https://doi.org/10.1089/oli.2006.16.83
Autor:
Kanyalakshmi Ayyanar, Massimo Iacobelli, Paul G. Richardson, Noah Kornblum, Cy A. Stein, Luba Benimetskaya
Publikováno v:
Oligonucleotides. 16:105-114
Veno-occlusive disease of the liver (VOD) remains a troubling and potentially fatal complication of high-dose chemotherapy and hematopoietic stem cell transplantation conditioning regimens. No effective therapy has been available for these patients t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5a4d5d0f16d529216fba938a0c6e1e0
https://doi.org/10.1089/oli.2006.16.105
https://doi.org/10.1089/oli.2006.16.105
Autor:
Cy A. Stein, Paul S. Miller, Luba Benimetskaya, Anastasia Khvorova, Johnathan C. Lai, Sijian Wu
Publikováno v:
Annals of the New York Academy of Sciences. 1058:235-245
G3139 is an 18mer phosphorothioate oligonucleotide targeted to the initiation codon region of the Bcl-2 mRNA. Because of the ability of this antisense construct to downregulate the expression of Bcl-2 mRNA and protein, it has entered phase III clinic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53df9c675df6188b449940225b60d85e
https://doi.org/10.1196/annals.1359.033
https://doi.org/10.1196/annals.1359.033
Autor:
Luba Benimetskaya, Diane D. Ilsley, Anastasia Khvorova, Cy A. Stein, Paul S. Miller, Emily M. Anderson, William Marshall
Publikováno v:
Cancer Gene Therapy. 13:406-414
G3139 is a phosphorothioate oligodeoxyribonucleotide that is targeted to the initiation codon region of the Bcl-2 mRNA, which downregulates Bcl-2 protein and mRNA expression via an antisense mechanism. In previous work, we have demonstrated that the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab38cf759b3e54a1b1589b307a74cd93
https://doi.org/10.1038/sj.cgt.7700901
https://doi.org/10.1038/sj.cgt.7700901
Publikováno v:
Oligonucleotides. 15:206-214
G3139 is an antisense Bcl-2 phosphorothioate oligonucleotide that has been combined with DTIC in a phase III clinical trial in melanoma. However, its actual mechanism of action in melanoma is controversial. Treatment of 518A2 melanoma cells with eith
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1359eb998c19d1773deb0d6d031c74cf
https://doi.org/10.1089/oli.2005.15.206
https://doi.org/10.1089/oli.2005.15.206
Autor:
Cy A. Stein, Li Ming Zhang, Sijian Wu, Johnathan C. Lai, Luba Benimetskaya, Anastasia Khvorova, Emily Hua, Paul S. Miller
Publikováno v:
Clinical Cancer Research. 10:8371-8379
Purpose: Inhibition of the function of Bcl-2 protein has been postulated to sensitize cells to cytotoxic chemotherapy. G3139 (Genasense) is a phosphorothioate anti–Bcl-2 antisense oligonucleotide, but its mechanism of action is uncertain. The aim o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a02a14e0ac7abe1f7828bae61c622a2e
https://doi.org/10.1158/1078-0432.ccr-04-1294
https://doi.org/10.1158/1078-0432.ccr-04-1294