Výsledky vyhledávání

The Aβ1–42M35C mutated amyloid peptide Aβ1–42 and the 25–35 fragment fail to mimic the subtype-specificity of actions on recombinant human nicotinic acetylcholine receptors (α7, α4β2, α3β4)

Autor: Steven D. Buckingham, Victor I. Tsetlin, C.A.R. Boyd, Luanda Pym, David B. Sattelle

Publikováno v: Neuroscience Letters. 427:28-33

Alzheimer's disease (AD) is a neurodegenerative condition involving accumulation of the beta-amyloid peptide, Abeta1-42. Previously we have shown that amyloid peptides (Abeta1-42, Abeta1-40) have different actions on the three major brain nicotinic a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::95e164f6635d1128d1571ded57864155
https://doi.org/10.1016/j.neulet.2007.08.041

Zobrazit plný text záznamu

Subtype-specific actions of β -amyloid peptides on recombinant human neuronal nicotinic acetylcholine receptors (α 7, α 4β 2, α 3β 4) expressed in Xenopus laevis oocytes

Autor: Valérie Raymond-Delpech, Steven D. Buckingham, Luanda Pym, David B. Sattelle, Mark Kemp, C.A.R. Boyd

Publikováno v: British Journal of Pharmacology. 146:964-971

Two-electrode voltage-clamp electrophysiology has been used to study the actions of two amyloid peptides (Abeta(1-42), Abeta(1-40)) on alpha7, alpha4beta2 and alpha3beta4 recombinant human neuronal nicotinic acetylcholine receptors (nicotinic AChRs),

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::72f34f20c880625faf444aad487fa1ae
https://doi.org/10.1038/sj.bjp.0706403

Zobrazit plný text záznamu

Oocytes as an expression system for studying receptor/channel targets of drugs and pesticides

Autor: Steven David, Buckingham, Luanda, Pym, David Barry, Sattelle

Publikováno v: Methods in molecular biology (Clifton, N.J.). 322

The Xenopus laevis oocyte offers one of the most convenient expression systems for assaying the actions of candidate ligands on cloned ionotropic neurotransmitter receptors (also known as ligand-gated ion channels [LGICs]). Their large size makes inj

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::56db91733e2bb29be7d493b116bd230d
https://pubmed.ncbi.nlm.nih.gov/16739734

Zobrazit plný text záznamu

Alpha7 mutants mimicking atypical motifs (YxxCC of loop-C, and E to H at -1' in TM2) in the C. elegans LEV-8 subunit affect nicotinic acetylcholine receptor function

Autor: Luanda Pym, Maiko Yokota, Paula R. Towers, David B. Sattelle, Kazuhiko Matsuda

Publikováno v: Invertebrate neuroscience : IN. 6(2)

The ACR-8-like group of C. elegans nicotinic acetylcholine receptor (nAChR) subunits contain unusual motifs in the ACh binding site and in the -1' position of transmembrane region two (TM2). Using site-directed mutagenesis (SDM) we have introduced th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::104dd4342206040bbfaa144057e74804
https://pubmed.ncbi.nlm.nih.gov/16758254

Zobrazit plný text záznamu

Subtype-specific actions of beta-amyloid peptides on recombinant human neuronal nicotinic acetylcholine receptors (alpha7, alpha4beta2, alpha3beta4) expressed in Xenopus laevis oocytes

Autor: Luanda, Pym, Mark, Kemp, Valérie, Raymond-Delpech, Steven, Buckingham, C A R, Boyd, David, Sattelle

Publikováno v: British journal of pharmacology. 146(7)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bd983c97ae29baab91af990f2af68fae
https://pubmed.ncbi.nlm.nih.gov/16184187

Zobrazit plný text záznamu

A7DB: a relational database for mutational, physiological and pharmacological data related to the alpha7 nicotinic acetylcholine receptor

Autor: Steven D, Buckingham, Luanda, Pym, Andrew K, Jones, Laurence, Brown, Mark S P, Sansom, David B, Sattelle, Philip C, Biggin

Publikováno v: BMC Neuroscience

Nicotinic acetylcholine receptors (nAChRs) are pentameric proteins that are important drug targets for a variety of diseases including Alzheimer's, schizophrenia and various forms of epilepsy. One of the most intensively studied nAChR subunits in rec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::915eb47bdf42c67d183ecf1c7541d610
https://pubmed.ncbi.nlm.nih.gov/15661073

Zobrazit plný text záznamu

[Untitled]

Autor: Steven D. Buckingham, Laurence A. Brown, Andrew K. Jones, Philip C. Biggin, David B. Sattelle, Luanda Pym, Mark S.P. Sansom

Publikováno v: BMC Neuroscience. 6:2

Background Nicotinic acetylcholine receptors (nAChRs) are pentameric proteins that are important drug targets for a variety of diseases including Alzheimer's, schizophrenia and various forms of epilepsy. One of the most intensively studied nAChR subu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7d1ef786cd9c796d78a236a07e03be7f
https://doi.org/10.1186/1471-2202-6-2

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání