Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Luana Schito"'
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 9, Pp n/a-n/a (2020)
Abstract Conventional maximum‐tolerated dose (MTD) chemotherapy relies on periodic, massive cancer cell ablation events followed by treatment‐free intermissions, stereotypically resulting in resistance, relapse, and mortality. Furthermore, MTD ch
Externí odkaz:
https://doaj.org/article/0b3e5cb868fd4fc29e19318ae9960787
Autor:
Luana Schito, Sergio Rey
Publikováno v:
Trends in Cancer. 8:771-784
The lymphatic system is a major component of the tumor microenvironment, wherein lymphovascular remodeling occurs as a response to low O
Autor:
Sergio Rey-Keim, Luana Schito
Hypoxia (low O2) signals into the nucleus of cancer cells through hypoxia-inducible factor (HIF)-1α-dependent transcription triggering proliferative, metabolic and vascular adaptations linked to therapy resistance and mortality due to overt metastas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a73b99afc2ab2dae8417da0cce8118c3
https://doi.org/10.1101/2022.11.03.515032
https://doi.org/10.1101/2022.11.03.515032
Autor:
Takashi Akiyoshi, Regina Beets-Tan, Sean Benson, Zuhir Bodalal, Nelleke Pietronella Maria Brouwer, Jacobus Burggraaf, Lishan Cai, Wim P. Ceelen, Daniel T. Chang, Alexander De Clercq, Charlotte Debbaut, Carlos Alejandro Silvera Delgado, Alexandra Elias, Kai Francke, Melissa A. Frick, Hidde A. Galema, Dedecker Hans, Prenen Hans, Karin Hardiman, Sanne-Marije J.A. Hazen, Denise E. Hilling, Anne Hoorens, Merlijn Hutteman, Masataka Ikeda, Masaaki Ito, Albert Jan, Yukihide Kanemitsu, Kozo Kataoka, Stijn Keereweer, Ghazal Adeli Koudehi, Miranda Kusters, Wuyts Laura, Teuwen Laure-Anne, Lorraine J. Lauwerends, Phoebe Loo, Monique Maas, Peeters Marc, Ruben P.J. Meijer, John R.T. Monson, Iris D. Nagtegaal, Erqi L. Pollom, Sergio Rey, Hooman Salavati, Luana Schito, Patrick Segers, Manabu Shiozawa, Tania C. Sluckin, Mary Smithson, Mathieu J.R. Struys, Jim P. Tiernan, ten Tije, Vandamme Timon, Stefano Trebeschi, Yuichiro Tsukada, Alexander L. Vahrmeijer, Gabrielle H. van Ramshorst, Cornelis Verhoef, Lucas K. Vitzthum, Selam Waktola, Nicholas P. West, Alice C. Westwood, Wouter Willaert, Jesse P. Wright
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::72853027fded31cff902e42ed3f19871
https://doi.org/10.1016/b978-0-12-824297-1.00023-3
https://doi.org/10.1016/b978-0-12-824297-1.00023-3
Autor:
Luana Schito
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 315:R1072-R1084
Hypoxia (low O2) is a ubiquitous microenvironmental factor promoting cancer progression, metastasis, and mortality, owing to the ability of cancer cells to co-opt physiological angiogenic responses. Notwithstanding, the pathophysiological induction o
Publikováno v:
EMBO Molecular Medicine
EMBO Molecular Medicine, Vol 12, Iss 9, Pp n/a-n/a (2020)
EMBO Molecular Medicine, Vol 12, Iss 9, Pp n/a-n/a (2020)
Conventional maximum‐tolerated dose (MTD) chemotherapy relies on periodic, massive cancer cell ablation events followed by treatment‐free intermissions, stereotypically resulting in resistance, relapse, and mortality. Furthermore, MTD chemotherap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60fa1fd9b9770ceb356bbbb0e25bc367
Autor:
Sergio Rey, Luana Schito
Hypoxia is a universal feature of solid cancers caused by a mismatch between cellular oxygen supply and consumption. To meet the increased demand for oxygen, hypoxic cancer cells (CCs) induce a multifaceted process known as angiogenesis, wherein new
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ff8f03d1fbebf5e8a31bd0774f4cb5a
Autor:
Luana Schito, Sergio Rey
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer. 1868:239-245
Dissemination of breast cancer cells (BCCs) to distant sites (metastasis) is the ultimate cause of mortality in patients with breast cancer. Hypoxia (low O2) is a microenvironmental hallmark of most solid cancers arising as a mismatch between cellula
Publikováno v:
Oncogene. 36:5331-5340
Hypoxia (low O2) is a fundamental microenvironmental determinant of bone marrow (BM) pathophysiology. Recent data from molecular and clinical studies indicate that hematopoiesis and leukemogenesis are dependent upon hypoxia-inducible factors (HIFs),