Výsledky vyhledávání - "Luana R.M.M. Aps"

Antigen delivery to DEC205+ dendritic cells induces immunological memory and protective therapeutic effects against HPV-associated tumors at different anatomical sites

Autor: Jamile Ramos da Silva, Bianca da Silva Almeida, Karine Bitencourt Rodrigues, Mariana O. Diniz, Luís Carlos de Souza Ferreira, Bruna F.M.M. Porchia, Luana R.M.M. Aps, Silvia Beatriz Boscardin, Fernando Bandeira Sulczewski, Natiely Silva Sales, Ana Carolina Ramos Moreno, Mariângela de Oliveira Silva

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
International Journal of Biological Sciences

The generation of successful anticancer vaccines relies on the ability to induce efficient and long-lasting immune responses to tumor antigens. In this scenario, dendritic cells (DCs) are essential cellular components in the generation of antitumor i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67e424df621def3bcd7ddd4e13f9be84

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A therapeutic DNA vaccine and gemcitabine act synergistically to eradicate HPV-associated tumors in a preclinical model

Autor: Ana Carolina Ramos Moreno, Aléxia Adrianne Venceslau-Carvalho, Mariângela de Oliveira Silva, Natiely Silva Sales, Carlos Frederico Martins Menck, Jamile Ramos da Silva, Luana R.M.M. Aps, Luís Carlos de Souza Ferreira, Bruna F.M.M. Porchia, Natália Cestari Moreno, Karine Bitencourt Rodrigues, Mariana O. Diniz

Publikováno v: OncoImmunology, Vol 10, Iss 1 (2021)
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Oncoimmunology
article-version (VoR) Version of Record

Although active immunotherapies are effective strategies to induce activation of CD8+ T cells, advanced stage tumors require further improvements for efficient control. Concerning the burden of cancer-related to Human papillomavirus (HPV), particular

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::523d4a01c5795bae487ae172dbd638e0
https://doaj.org/article/19e260baa8fb498cbacd5646e994683c

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In vivo electroporation enhances vaccine-mediated therapeutic control of human papilloma virus-associated tumors by the activation of multifunctional and effector memory CD8+ T cells

Autor: Luana R.M.M. Aps, Mariângela de Oliveira Silva, Luís Carlos de Souza Ferreira, Natiely Silva Sales, Bruna F.M.M. Porchia, Jamile Ramos da Silva, Mariana O. Diniz

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

In vivo electroporation (EP) has reignited the clinical interest on DNA vaccines as immunotherapeutic approaches to control different types of cancer. EP has been associated with increased immune response potency, but its capacity in influencing immu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b202bb22fb40667bd6e09700d60bd6e7
https://doi.org/10.1016/j.vaccine.2017.11.011

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Expression of a soluble IL-10 receptor enhances the therapeutic effects of a papillomavirus-associated antitumor vaccine in a murine model

Autor: Jamile Ramos da Silva, Luís Carlos de Souza Ferreira, Natiely Silva Sales, Ana Carolina Ramos Moreno, Mariângela de Oliveira Silva, Elaine G. Rodrigues, Mariana O. Diniz, Luana R.M.M. Aps

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

The presence of IL-10, produced either by tumor cells or immunosuppressive cells, is frequently associated with a poor prognosis for cancer progression. It may also negatively impact anticancer treatments, such as immunotherapies, that otherwise woul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dee5e0792815296ecab8a5acadf3757b

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Gene delivery and immunomodulatory effects of plasmid DNA associated with Branched Amphiphilic Peptide Capsules

Autor: Rúbens Prince dos Santos Alves, R. Guo, Pinakin Sukthankar, Luana R.M.M. Aps, Luís Carlos de Souza Ferreira, Nicoleta Ploscariu, Robert Szoszkiewicz, Mariana O. Diniz, L.A. Avila, Y. Fang, Patrícia Dias Games, John M. Tomich, K.E. Wilkinson

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

We recently reported on a new class of branched amphiphilic peptides that associate with double stranded DNA and promote in vitro transfection of eukaryotic cells. In the present study, we tested a different formulation in which plasmid DNA associate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ce5afab8bbe5a4e16ea7298a4ffa0ee
https://doi.org/10.1016/j.jconrel.2016.08.042

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Bacterial spores as particulate carriers for gene gun delivery of plasmid DNA

Autor: Mariana O. Diniz, Julio H.K. Rozenfeld, M. Teresa Lamy, Luís Carlos de Souza Ferreira, Milene B. Tavares, Luana R.M.M. Aps

Publikováno v: Journal of Biotechnology. 228:58-66

Bacillus subtilis spores represent a suitable platform for the adsorption of proteins, enzymes and viral particles at physiological conditions. In the present work, we demonstrate that purified spores can also adsorb DNA on their surface after treatm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4391e863538054472fbd0f235bf82f9c
https://doi.org/10.1016/j.jbiotec.2016.04.027

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Bacillus subtilis spores as adjuvants for DNA vaccines

Autor: Luana R.M.M. Aps, Luís Carlos de Souza Ferreira, Bruna F.M.M. Porchia, Natiely Silva Sales, Ana Carolina Ramos Moreno, Mariana O. Diniz

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Recently, Bacillus subtilis spores were shown to be endowed with strong adjuvant capacity when co-administered with purified antigenic proteins. In the present study we assessed whether spores possess adjuvant properties when combined with DNA vaccin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48bb472c66a35ecd00f31b38f6ca521c
https://doi.org/10.1016/j.vaccine.2015.03.043

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Eventos adversos de vacinas e as consequências da não vacinação: uma análise crítica

Autor: Sara Araujo Pereira, Marco Aurélio Floriano Piantola, Fernanda Ayane de Oliveira Santos, Luís Carlos de Souza Ferreira, Luana R.M.M. Aps, Julia Tavares de Castro

Publikováno v: Revista de Saúde Pública. 52:40

OBJETIVO: Analisar os riscos relacionados às vacinas e os impactos da não vacinação para a população mundial. MÉTODOS: Revisão narrativa que considerou informações contidas nas bases de dados bibliográficos NCBI-PubMed, Medline, Lilacs e S

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bc9e545d137af42ae0a3b068be96ad63
https://doi.org/10.11606/s1518-8787.2018052000384

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Abstract A65: In vivo neutralization of IL-10 enhances the antitumor effects of a therapeutic vaccine against HPV-associated tumor

Autor: Jamile Ramos da Silva, Luís Carlos de Souza Ferreira, Luana R.M.M. Aps, Mariana O. Diniz, Mariangela de Oliveira Silva, Natiely Silva Sales

Publikováno v: Clinical Cancer Research. 24:A65-A65

Although experimental therapeutic vaccines against HPV-induced tumors are capable of activating systemic E6 and E7-specific CD8+ T cells and inducing high levels of antitumor protection in murine model, they do not always correlate with clinical effi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3412d0e698673974929b76b6a2daae16
https://doi.org/10.1158/1557-3265.tcm17-a65

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